PMID- 31784133 OWN - NLM STAT- MEDLINE DCOM- 20210106 LR - 20210106 IS - 1873-3336 (Electronic) IS - 0304-3894 (Linking) VI - 386 DP - 2020 Mar 15 TI - Joint effect of polycyclic aromatic hydrocarbons and phthalates exposure on telomere length and lung function. PG - 121663 LID - S0304-3894(19)31617-6 [pii] LID - 10.1016/j.jhazmat.2019.121663 [doi] AB - Exposure to polycyclic aromatic hydrocarbons and phthalates are linked to lung function decline and altered relative telomere length (RTL) accompanying with oxidative stress and inflammatory events in human body. However, limited data are available about impacts of co-exposure of PAHs and phthalates on lung function and RTL. We conducted a pilot study with repeated measures during the winter of 2014 and summer of 2015 in Wuhan city, China. Participants took part in the measures of lung function, RTL, urinary monohydroxylated-PAHs (OH-PAHs) and phthalate metabolites over three consecutive days in each season. Linear mixed-effect (LME) models and Bayesian kernel machine regression (BKMR) were used to analyze the relations of OH-PAHs or phthalate metabolites with lung function or RTL. LME models showed the negative associations of 3-day average of hydroxyphenanthrene (2 + 3-, 4-OHPhe) or 1-hydroxypyrene with FEV1, 3-day average of 2 + 3-OHPhe with FVC. BKMR models revealed the negative relation of eight OH-PAHs with FEV1, FVC or RTL; nine phthalate metabolites may counteract an overall effect of eight OH-PAHs on FEV1, FVC or RTL. The findings indicated that urinary phthalate metabolites may counteract the negative association of urinary OH-PAHs on FEV1 or FVC, which may be partially linked to shorter RTL regarding biological aging. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Hou, Jian AU - Hou J AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Yin, Wenjun AU - Yin W AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Li, Pei AU - Li P AD - State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China. FAU - Hu, Chen AU - Hu C AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Xu, Tian AU - Xu T AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Cheng, Juan AU - Cheng J AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Li, Tian AU - Li T AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Wang, Lin AU - Wang L AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Yu, Zhiqiang AU - Yu Z AD - State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China. FAU - Yuan, Jing AU - Yuan J AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. Electronic address: jyuan@tjh.tjmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191115 PL - Netherlands TA - J Hazard Mater JT - Journal of hazardous materials JID - 9422688 RN - 0 (Complex Mixtures) RN - 0 (Phthalic Acids) RN - 0 (Polycyclic Aromatic Hydrocarbons) SB - IM MH - Adolescent MH - Adult MH - China MH - Complex Mixtures/toxicity MH - Female MH - Humans MH - Lung/*drug effects/physiology MH - Male MH - Middle Aged MH - Phthalic Acids/*toxicity MH - Polycyclic Aromatic Hydrocarbons/*toxicity MH - *Respiratory Function Tests MH - Telomere/*drug effects MH - Young Adult OTO - NOTNLM OT - Bayesian kernel machine regression OT - Lung function OT - Phthalates OT - Polycyclic aromatic hydrocarbons OT - Relative telomere length COIS- Declaration of Competing Interest None declare. EDAT- 2019/12/01 06:00 MHDA- 2021/01/07 06:00 CRDT- 2019/12/01 06:00 PHST- 2019/05/24 00:00 [received] PHST- 2019/11/05 00:00 [revised] PHST- 2019/11/10 00:00 [accepted] PHST- 2019/12/01 06:00 [pubmed] PHST- 2021/01/07 06:00 [medline] PHST- 2019/12/01 06:00 [entrez] AID - S0304-3894(19)31617-6 [pii] AID - 10.1016/j.jhazmat.2019.121663 [doi] PST - ppublish SO - J Hazard Mater. 2020 Mar 15;386:121663. doi: 10.1016/j.jhazmat.2019.121663. Epub 2019 Nov 15.