PMID- 31784859
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1573-7322 (Electronic)
IS  - 1382-4147 (Linking)
VI  - 25
IP  - 6
DP  - 2020 Nov
TI  - The pivotal role of cardiovascular imaging in the identification and risk 
      stratification of non-compaction cardiomyopathy patients.
PG  - 1007-1015
LID - 10.1007/s10741-019-09898-8 [doi]
AB  - Non-compaction cardiomyopathy (NCM) is a heterogeneous myocardial disease that 
      can finally lead to heart failure, arrhythmias, and/or embolic events. Therefore, 
      early diagnosis and treatment is of paramount importance. Furthermore, genetic 
      assessment and counseling are crucial for individual risk assessment and family 
      planning. Echocardiography is the first-line imaging modality. However, it is 
      hampered by interobserver variability, depends among others on the quality of the 
      acoustic window, cannot assess reliably the right ventricle and the apex, and 
      cannot provide tissue characterization. Cardiovascular magnetic resonance (CMR) 
      provides a 3D approach allowing imaging of the entire heart, including both left 
      and right ventricle, with low operator variability or limitations due to 
      patient's body structure. Furthermore, tissue characterization, using late 
      gadolinium enhancement (LGE), allows the detection of fibrotic areas possibly 
      representing the substrate for potentially lethal arrhythmias, predicts the 
      severity of LV systolic dysfunction, and differentiates apical thrombus from 
      fibrosis. Conversely, besides being associated with high costs, CMR has long 
      acquisition/processing times, lack of expertise among cardiologists/radiologists, 
      and limited availability. Additionally, in cases of respiratory and/or cardiac 
      motion artifacts or arrhythmias, the cine images may be blurred. However, CMR 
      cannot be applied to patients with not CMR-compatible implanted devices and LGE 
      may be not available in patients with severely reduced GFR. Nevertheless, native 
      T1 mapping can provide detailed tissue characterization in such cases. This 
      tremendous potential of CMR makes this modality the ideal tool for better risk 
      stratification of NCM patient, based not only on functional but also on tissue 
      characterization information.
FAU - Mavrogeni, Sophie I
AU  - Mavrogeni SI
AD  - Onassis Cardiac Surgery Center, Athens, Greece. sophie.mavrogeni@gmail.com.
AD  - Department of Cardiology, and National and Kapodistrian University of Athens, 
      Leoforos Andrea Syngrou 356, Kallithea, 17674, Athens, Greece. 
      sophie.mavrogeni@gmail.com.
FAU - Markousis-Mavrogenis, George
AU  - Markousis-Mavrogenis G
AD  - Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Vartela, Vasiliki
AU  - Vartela V
AD  - Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Manolopoulou, Dionysia
AU  - Manolopoulou D
AD  - Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Abate, Elena
AU  - Abate E
AD  - Mid-German Heart Center, Department of Internal Medicine III (KIM-III), Division 
      of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, 
      Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle 
      (Saale), Germany.
FAU - Hamadanchi, Ali
AU  - Hamadanchi A
AD  - Department of Internal Medicine I, Division of Cardiology, Pneumology, Angiology 
      and Intensive Medical Care, University Hospital Jena, 
      Friedrich-Schiller-University Jena, Jena, Germany.
FAU - Rigopoulos, Angelos G
AU  - Rigopoulos AG
AD  - Mid-German Heart Center, Department of Internal Medicine III (KIM-III), Division 
      of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, 
      Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle 
      (Saale), Germany.
FAU - Kolovou, Genovefa
AU  - Kolovou G
AD  - Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Noutsias, Michel
AU  - Noutsias M
AD  - Mid-German Heart Center, Department of Internal Medicine III (KIM-III), Division 
      of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, 
      Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle 
      (Saale), Germany.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Heart Fail Rev
JT  - Heart failure reviews
JID - 9612481
SB  - IM
MH  - Cardiomyopathies/*diagnosis/epidemiology/physiopathology
MH  - Echocardiography/*methods
MH  - Global Health
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Morbidity/trends
MH  - Predictive Value of Tests
MH  - Risk Assessment/*methods
MH  - Stroke Volume/*physiology
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - Arrhythmia, embolic event
OT  - Cardiovascular magnetic resonance
OT  - Echocardiography
OT  - Heart failure
OT  - Non-compaction cardiomyopathy
EDAT- 2019/12/01 06:00
MHDA- 2021/07/06 06:00
CRDT- 2019/12/01 06:00
PHST- 2019/12/01 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2019/12/01 06:00 [entrez]
AID - 10.1007/s10741-019-09898-8 [pii]
AID - 10.1007/s10741-019-09898-8 [doi]
PST - ppublish
SO  - Heart Fail Rev. 2020 Nov;25(6):1007-1015. doi: 10.1007/s10741-019-09898-8.