PMID- 31785068
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20210916
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 41
IP  - 5
DP  - 2020 Apr 1
TI  - Pain modulates neural responses to reward in the medial prefrontal cortex.
PG  - 1372-1381
LID - 10.1002/hbm.24882 [doi]
AB  - Pain has been found to promote reward-seeking behaviors, which might be a 
      consequence of modulated brain activities in the reward neural circuitry in a 
      painful state. The present study investigated how pain affected reward processing 
      and reward-related neural activities using fMRI technique. A total of 50 healthy 
      participants were recruited and used for data analyses, with half being treated 
      with topical capsaicin cream and the other half with hand cream (treatment: pain 
      or control). The participants were asked to perform a card-guessing game when 
      their brain activities responding to feedbacks (outcome: win or loss) were 
      recorded. Behavioral results showed that participants in pain group overestimated 
      their correct choices in the card-guess game. Whole-brain fMRI analysis revealed 
      that the main effect of outcome (win vs. loss) activated a typical network of the 
      reward neural circuitry, including the medial prefrontal cortex (mPFC) and the 
      bilateral nucleus accumbens (NAcc). Importantly, the region of interest analysis 
      revealed a significant interaction of treatment and outcome in the mPFC, with 
      increased mPFC neural activity responding to win outcome in pain condition. 
      Moreover, the functional connectivity between the mPFC and the NAcc was decreased 
      in pain condition. We conclude that the pain-induced modulation of the mPFC 
      activity could result in alterations of both the emotional response to and the 
      cognitive evaluation of reward.
CI  - (c) 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
FAU - Wang, Chenbo
AU  - Wang C
AUID- ORCID: 0000-0002-1423-0726
AD  - Key Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU 
      Mental Health Center, Institute of Cognitive Neuroscience, School of Psychology 
      and Cognitive Science, East China Normal University, Shanghai, China.
FAU - Bao, Chaofei
AU  - Bao C
AD  - Key Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU 
      Mental Health Center, Institute of Cognitive Neuroscience, School of Psychology 
      and Cognitive Science, East China Normal University, Shanghai, China.
FAU - Gao, Jiatao
AU  - Gao J
AD  - Key Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU 
      Mental Health Center, Institute of Cognitive Neuroscience, School of Psychology 
      and Cognitive Science, East China Normal University, Shanghai, China.
FAU - Gu, Yujin
AU  - Gu Y
AD  - Key Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU 
      Mental Health Center, Institute of Cognitive Neuroscience, School of Psychology 
      and Cognitive Science, East China Normal University, Shanghai, China.
FAU - Dong, Xiao-Wei
AU  - Dong XW
AD  - Key Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU 
      Mental Health Center, Institute of Cognitive Neuroscience, School of Psychology 
      and Cognitive Science, East China Normal University, Shanghai, China.
AD  - NYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191129
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
RN  - S07O44R1ZM (Capsaicin)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Brain Mapping
MH  - Capsaicin
MH  - Feedback, Psychological
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/diagnostic imaging/physiopathology
MH  - Nucleus Accumbens/diagnostic imaging/physiopathology
MH  - Oxygen/blood
MH  - Pain/chemically induced/diagnostic imaging/*physiopathology
MH  - Prefrontal Cortex/diagnostic imaging/*physiopathology
MH  - Psychophysics
MH  - *Reward
MH  - Self Concept
MH  - Young Adult
PMC - PMC7267926
OTO - NOTNLM
OT  - NAcc
OT  - fMRI
OT  - mPFC
OT  - pain
OT  - reward
COIS- The authors declare no conflicts of interest.
EDAT- 2019/12/01 06:00
MHDA- 2021/09/18 06:00
PMCR- 2019/11/29
CRDT- 2019/12/01 06:00
PHST- 2019/09/23 00:00 [received]
PHST- 2019/11/09 00:00 [revised]
PHST- 2019/11/19 00:00 [accepted]
PHST- 2019/12/01 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2019/12/01 06:00 [entrez]
PHST- 2019/11/29 00:00 [pmc-release]
AID - HBM24882 [pii]
AID - 10.1002/hbm.24882 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2020 Apr 1;41(5):1372-1381. doi: 10.1002/hbm.24882. Epub 2019 Nov 
      29.