PMID- 31785132
OWN - NLM
STAT- MEDLINE
DCOM- 20210326
LR  - 20231113
IS  - 2324-9269 (Electronic)
IS  - 2324-9269 (Linking)
VI  - 8
IP  - 1
DP  - 2020 Jan
TI  - Relationship between HLA-DPA1 genetic polymorphism and anembryonic pregnancy.
PG  - e1046
LID - 10.1002/mgg3.1046 [doi]
LID - e1046
AB  - BACKGROUND: Human leukocyte antigen (HLA)-DP is an HLA class II molecule. 
      Overexpression of HLA class II molecules in placental trophoblast cells may 
      induce pregnancy loss. However, the association between HLA-DP and pregnancy loss 
      remains unclear. HLA-DPA1 is an HLA-DP peptide chain. The objective of this study 
      was to assess the association between HLA-DPA1 genetic polymorphism and 
      anembryonic pregnancy, a type of early pregnancy loss, in the Chinese population. 
      METHODS: A case-control study was designed to compare the frequencies of HLA-DPA1 
      gene polymorphisms in an anembryonic pregnancy group and a control group. 
      Sixty-eight cases and 122 controls were recruited. Statistical analysis was 
      performed to assess the correlation between single-nucleotide polymorphisms 
      (SNPs) and anembryonic pregnancy susceptibility. MassARRAY high-throughput DNA 
      analysis was used to analyze 19 HLA-DPA1 SNPs. To explore how HLA-DPA1 
      polymorphism could affect anembryonic pregnancy, HLA-DPA1 serum levels were 
      analyzed by ELISA. RESULTS: Homozygous typing of rs1431403 (CC and TT) 
      significantly increased the risk of anembryonic pregnancy in the case group 
      (OR(CC)  = 3.13, 95% CI: 1.50-6.53; OR(TT)  = 2.96, 95% CI: 1.31-6.66; OR(CC+TT) 
       = 3.06, 95% CI: 1.62-5.78). In samples with high HLA-DPA1 levels (>/=1,500 pg/ml), 
      the homozygous rs1431403 genotypes (n(CC)  = 21, 43.8%; n(TT)  = 20, 57.1%) were 
      observed more frequently than were heterozygous genotypes. CONCLUSION: HLA-DPA1 
      rs1431403 may be a risk factor for anembryonic pregnancy in the Chinese 
      population. Homozygous rs1431403 genotypes (CC and TT) may increase the risk of 
      anembryonic pregnancy by aberrantly increasing the HLA-DPA1 levels.
CI  - (c) 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley 
      Periodicals, Inc.
FAU - Wang, Zhendong
AU  - Wang Z
AUID- ORCID: 0000-0001-8545-0227
AD  - Laboratory of Biochemistry and Molecular Biology, Shanxi Medical University, 
      Shanxi, China.
FAU - Lu, Xiaolin
AU  - Lu X
AD  - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital 
      Institute of Pediatrics, Beijing, P.R. China.
FAU - Yao, Xiuying
AU  - Yao X
AD  - Department of Obstetrics and Gynecology, PLA General Hospital 263th Clinical 
      Department, Beijing, China.
FAU - Liu, Xinli
AU  - Liu X
AD  - Department of Obstetrics and Gynecology, PLA General Hospital 263th Clinical 
      Department, Beijing, China.
FAU - Zhao, Linlin
AU  - Zhao L
AD  - Department of Obstetrics and Gynecology, PLA General Hospital 263th Clinical 
      Department, Beijing, China.
FAU - Chang, Shaoyan
AU  - Chang S
AD  - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital 
      Institute of Pediatrics, Beijing, P.R. China.
FAU - Zhang, Ting
AU  - Zhang T
AD  - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital 
      Institute of Pediatrics, Beijing, P.R. China.
FAU - Niu, Bo
AU  - Niu B
AD  - Laboratory of Biochemistry and Molecular Biology, Shanxi Medical University, 
      Shanxi, China.
AD  - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital 
      Institute of Pediatrics, Beijing, P.R. China.
FAU - Wang, Li
AU  - Wang L
AD  - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital 
      Institute of Pediatrics, Beijing, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191130
PL  - United States
TA  - Mol Genet Genomic Med
JT  - Molecular genetics & genomic medicine
JID - 101603758
RN  - 0 (HLA-DP alpha-Chains)
RN  - 0 (HLA-DPA1 antigen)
SB  - IM
MH  - Abortion, Spontaneous/*genetics/pathology
MH  - Adult
MH  - Female
MH  - HLA-DP alpha-Chains/*genetics
MH  - Humans
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Pregnancy
PMC - PMC6978238
OTO - NOTNLM
OT  - HLA-DPA1
OT  - Immune Factors
OT  - Single-nucleotide polymorphism (SNP)
OT  - anembryonic pregnancy
OT  - association study
COIS- We declare that we have no financial and personal relationships with other people 
      or organizations that can inappropriately influence our work, there is no 
      professional or other personal interest of any nature or kind in any product, 
      service, and/or company that could be construed as influencing the position 
      presented in, or the review of, the manuscript entitled, "Relationship between 
      HLA-DPA1 Genetic Polymorphism and Anembryonic Pregnancy".
EDAT- 2019/12/01 06:00
MHDA- 2021/03/27 06:00
PMCR- 2019/11/30
CRDT- 2019/12/01 06:00
PHST- 2019/05/29 00:00 [received]
PHST- 2019/10/05 00:00 [revised]
PHST- 2019/10/11 00:00 [accepted]
PHST- 2019/12/01 06:00 [pubmed]
PHST- 2021/03/27 06:00 [medline]
PHST- 2019/12/01 06:00 [entrez]
PHST- 2019/11/30 00:00 [pmc-release]
AID - MGG31046 [pii]
AID - 10.1002/mgg3.1046 [doi]
PST - ppublish
SO  - Mol Genet Genomic Med. 2020 Jan;8(1):e1046. doi: 10.1002/mgg3.1046. Epub 2019 Nov 
      30.