PMID- 31785367
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20211121
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Print)
IS  - 1081-1206 (Linking)
VI  - 124
IP  - 2
DP  - 2020 Feb
TI  - alpha-Gal and other recent findings that have informed our understanding of 
      anaphylaxis.
PG  - 135-142
LID - S1081-1206(19)31454-1 [pii]
LID - 10.1016/j.anai.2019.11.024 [doi]
AB  - OBJECTIVE: To summarize the current understanding of anaphylaxis, with an 
      emphasis on major findings that have been reported within the last 10 years. DATA 
      SOURCES: Queries relating to anaphylaxis, immunoglobulin E (IgE), and mast cells 
      were conducted with PubMed and Google Scholar, searching for primary articles and 
      review papers. STUDY SELECTIONS: We focused on articles written in English and 
      which were reported in major allergy and immunology journals. RESULTS: 
      Anaphylaxis represents an extreme manifestation of a form of allergic immunity 
      that appears to have evolved to protect against "toxic" threats that present at 
      skin and mucosal barriers. The factors that have contributed to a rise in 
      anaphylaxis are increasingly appreciated to relate to changes in hygiene and 
      microbial ecology that have occurred with industrialization. Induction of 
      allergen-specific IgG4 is often part of the allergic response and is associated 
      with protection against anaphylaxis. The recognition of the alpha-Gal syndrome 
      suggests that carbohydrates can be epitopes that are relevant to anaphylaxis and 
      that IgE-mediated reactions do not always occur "immediately." CONCLUSION: Our 
      understanding of anaphylaxis has advanced significantly over the past 10 years. 
      It is anticipated that ongoing research will build on this foundation to further 
      advance our knowledge of anaphylaxis and also translate into clinically 
      meaningful therapies.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Wilson, Jeffrey M
AU  - Wilson JM
AD  - Division of Allergy & Immunology, University of Virginia, Charlottesville, VA, 
      22908.
FAU - Platts-Mills, Thomas A E
AU  - Platts-Mills TAE
AD  - Division of Allergy & Immunology, University of Virginia, Charlottesville, VA, 
      22908. Electronic address: tap2z@virginia.edu.
LA  - eng
GR  - R37 AI020565/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191128
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.2.1.22 (alpha-Galactosidase)
RN  - red meat allergy
SB  - IM
MH  - Allergens/*immunology
MH  - Anaphylaxis/*etiology
MH  - Animals
MH  - Food Hypersensitivity/immunology
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Immunoglobulin G/immunology
MH  - Microbiota
MH  - alpha-Galactosidase/*immunology
PMC - PMC7318893
MID - NIHMS1589943
EDAT- 2019/12/01 06:00
MHDA- 2020/04/28 06:00
PMCR- 2021/02/01
CRDT- 2019/12/01 06:00
PHST- 2019/09/26 00:00 [received]
PHST- 2019/11/19 00:00 [revised]
PHST- 2019/11/20 00:00 [accepted]
PHST- 2019/12/01 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
PHST- 2019/12/01 06:00 [entrez]
PHST- 2021/02/01 00:00 [pmc-release]
AID - S1081-1206(19)31454-1 [pii]
AID - 10.1016/j.anai.2019.11.024 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2020 Feb;124(2):135-142. doi: 
      10.1016/j.anai.2019.11.024. Epub 2019 Nov 28.