PMID- 31785428
OWN - NLM
STAT- MEDLINE
DCOM- 20200407
LR  - 20200408
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 128
DP  - 2020 Feb
TI  - Prevalence and time trend analysis of antimicrobial resistance in respiratory 
      bacterial pathogens collected from diseased pigs in USA between 2006-2016.
PG  - 135-144
LID - S0034-5288(19)30870-7 [pii]
LID - 10.1016/j.rvsc.2019.11.010 [doi]
AB  - Swine respiratory disease complex (SRDC) causes massive economic losses to the 
      swine industry and is a major animal welfare concern. Antimicrobials are mainstay 
      in treatment and control of SRDC. However, there is a lack of data on the 
      prevalence and trends in resistance to antimicrobials in bacterial pathogens 
      associated with SRDC. The objective of this study was to estimate the prevalence 
      and changes in resistance to 13 antimicrobials in swine bacterial pathogens 
      (Streptococcus suis, Pasteurella multocida, Actinobacillus suis and Haemophilus 
      parasuis) in the U.S.A using data collected at University of Minnesota Veterinary 
      Diagnostic Laboratory between 2006 and 2016. For antimicrobials for which 
      breakpoints were available, prevalence of resistance remained below 10% except 
      for tetracycline in S. suis and P. multocida isolates, and these prevalence 
      estimates remained consistently low over the years despite statistical 
      significance (p < .05) in trend analysis. For antimicrobial-bacterial 
      combinations without available breakpoints, the odds of isolates being resistant 
      increased by >10% annually for 7 and 1 antimicrobials in H. parasuis and S. suis 
      isolates respectively, and decreased >10% annually for 4 and 1 antimicrobials in 
      A. suis and H. parasuis isolates, respectively, according to the ordinal 
      regression models. Clinical implications of changes in AMR for A. suis and H. 
      parasuis should be interpreted cautiously due to the lack of interpretive 
      criteria and challenges in antimicrobial susceptibility tests in the case of H. 
      parasuis. Future studies should focus on surveillance of antimicrobial resistance 
      and establishment of standardized susceptibility testing methodologies and 
      interpretive criteria for these animal pathogens of critical importance.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Hayer, Shivdeep Singh
AU  - Hayer SS
AD  - Department of Veterinary Population Medicine, College of Veterinary Medicine, 
      University of Minnesota, St. Paul, USA.
FAU - Rovira, Albert
AU  - Rovira A
AD  - Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of 
      Minnesota, St. Paul, USA.
FAU - Olsen, Karen
AU  - Olsen K
AD  - Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of 
      Minnesota, St. Paul, USA.
FAU - Johnson, Timothy J
AU  - Johnson TJ
AD  - Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, 
      University of Minnesota, St. Paul, USA.
FAU - Vannucci, Fabio
AU  - Vannucci F
AD  - Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of 
      Minnesota, St. Paul, USA.
FAU - Rendahl, Aaron
AU  - Rendahl A
AD  - Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, 
      University of Minnesota, St. Paul, USA.
FAU - Perez, Andres
AU  - Perez A
AD  - Department of Veterinary Population Medicine, College of Veterinary Medicine, 
      University of Minnesota, St. Paul, USA.
FAU - Alvarez, Julio
AU  - Alvarez J
AD  - Department of Veterinary Population Medicine, College of Veterinary Medicine, 
      University of Minnesota, St. Paul, USA; VISAVET Health Surveillance Center, 
      Universidad Complutense, Madrid, Spain; Department of Animal Health, Facultad de 
      Veterinaria, Universidad Complutense, Madrid, Spain. Electronic address: 
      jalvarez@visavet.ucm.es.
LA  - eng
PT  - Journal Article
DEP - 20191121
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Bacteria/*drug effects
MH  - *Drug Resistance, Bacterial
MH  - Prevalence
MH  - Respiratory Tract Diseases/epidemiology/microbiology/*veterinary
MH  - Swine
MH  - Swine Diseases/epidemiology/*microbiology
MH  - United States/epidemiology
OTO - NOTNLM
OT  - Antimicrobial resistance
OT  - Pigs
OT  - Surveillance
OT  - Swine respiratory pathogens
EDAT- 2019/12/01 06:00
MHDA- 2020/04/09 06:00
CRDT- 2019/12/01 06:00
PHST- 2019/08/25 00:00 [received]
PHST- 2019/11/18 00:00 [revised]
PHST- 2019/11/19 00:00 [accepted]
PHST- 2019/12/01 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2019/12/01 06:00 [entrez]
AID - S0034-5288(19)30870-7 [pii]
AID - 10.1016/j.rvsc.2019.11.010 [doi]
PST - ppublish
SO  - Res Vet Sci. 2020 Feb;128:135-144. doi: 10.1016/j.rvsc.2019.11.010. Epub 2019 Nov 
      21.