PMID- 31785528
OWN - NLM
STAT- MEDLINE
DCOM- 20200727
LR  - 20200727
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 134
DP  - 2020 Jan
TI  - Cumulative exposure to organic pollutants of French children assessed by hair 
      analysis.
PG  - 105332
LID - S0160-4120(19)32722-9 [pii]
LID - 10.1016/j.envint.2019.105332 [doi]
AB  - Children represent one of the most vulnerable parts of the population regarding 
      the effects of pollutants exposure on health. In this study, hair samples were 
      collected between October 2013 and August 2015 from 142 French children 
      originating from different geographical areas (urban and rural) and analysed with 
      a GC/MS-MS method, allowing for the detection of 55 biomarkers for pesticides and 
      metabolites both persistent and non-persistent from different families, 
      including: organochlorines, organophosphates, pyrethroids, azoles, 
      dinitroanilines, oxadiazines, phenylpyrazoles and carboxamidas; 4 
      polychlorobiphenyls (PCBs) and 5 polybromodiphenylethers (PBDEs). The number of 
      compounds detected in each sample ranged from 9 up to 37 (21 on average), which 
      clearly highlighted the cumulative exposure of the children. The results also 
      showed a wide range of concentration of the pollutants in hair (often more than 
      100 times higher in the most exposed child compared to the less exposed), 
      suggesting significant disparities in the exposure level, even in children living 
      in the same area. In addition to the detection of currently used chemicals, the 
      presence of persistent organic pollutants (POPs) in children also suggests that 
      the French population is still exposed to POPs nowadays. PCP, DEP, PNP, 3Me4NP, 
      trans-Cl2CA, 3PBA, fipronil and fipronil sulfone, presented statistically 
      significant higher concentration in the hair of boys compared to girls. PCP, PNP 
      and 3Me4NP presented statistically significant higher concentration in younger 
      children. Finally, this study also suggests that local environmental 
      contamination would not be the main source of exposure, and that individual 
      specificities (habits, diet...) would be the main contributors to the exposure to 
      the pollutants analysed here. The present study strongly supports the relevance 
      of hair for the biomonitoring of exposure and provides the first values of 
      organic pollutant concentration in the hair of French children.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Iglesias-Gonzalez, Alba
AU  - Iglesias-Gonzalez A
AD  - Luxembourg Institute of Health, 1-A-B rue Thomas Edison, L-1445 Strassen, 
      Luxembourg; University of Luxembourg, 2, avenue de l'Universite, L-4365 
      Esch-sur-Alzette, Luxembourg. Electronic address: alba.iglesiasgonzalez@lih.lu.
FAU - Hardy, Emily M
AU  - Hardy EM
AD  - Luxembourg Institute of Health, 1-A-B rue Thomas Edison, L-1445 Strassen, 
      Luxembourg.
FAU - Appenzeller, Brice M R
AU  - Appenzeller BMR
AD  - Luxembourg Institute of Health, 1-A-B rue Thomas Edison, L-1445 Strassen, 
      Luxembourg.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191127
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
SB  - IM
MH  - Biomarkers/analysis
MH  - Child
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*analysis
MH  - Female
MH  - France
MH  - *Hair Analysis
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*analysis
MH  - Male
MH  - Pesticides/*analysis
OTO - NOTNLM
OT  - Children
OT  - Exposure
OT  - Hair analysis
OT  - Organic pollutants
EDAT- 2019/12/01 06:00
MHDA- 2020/07/28 06:00
CRDT- 2019/12/01 06:00
PHST- 2019/07/31 00:00 [received]
PHST- 2019/11/06 00:00 [revised]
PHST- 2019/11/12 00:00 [accepted]
PHST- 2019/12/01 06:00 [pubmed]
PHST- 2020/07/28 06:00 [medline]
PHST- 2019/12/01 06:00 [entrez]
AID - S0160-4120(19)32722-9 [pii]
AID - 10.1016/j.envint.2019.105332 [doi]
PST - ppublish
SO  - Environ Int. 2020 Jan;134:105332. doi: 10.1016/j.envint.2019.105332. Epub 2019 
      Nov 27.