PMID- 31788112
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 18
IP  - 6
DP  - 2019 Dec
TI  - Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of 
      immunohistochemistry and break-apart FISH in 45 cases.
PG  - 6355-6360
LID - 10.3892/ol.2019.10995 [doi]
AB  - Transcription factor E3 (TFE3) is a useful marker for tumors with Xp11.2 
      translocation, including alveolar soft part sarcoma and renal cell carcinoma. 
      Recently, TFE3 overexpression was also found in granular cell tumors (GrCTs). 
      However, the case cohorts of these two studies were limited to only 11 and 6 
      cases. Whether aberrant TFE3 expression is a common feature of Asian patients 
      with GrCT requires further investigation. In the present study, 
      immunohistochemical staining and TFE3 break-apart fluorescence in situ 
      hybridization (FISH) assay were performed in 45 samples of GrCTs obtained from 
      Chinese patients recruited from three medical centers in northeast China. 
      Diffusive and marked nuclear staining for TFE3 was identified in 11/45 (24%) 
      cases, which was lower than previously reported. Focal or weak TFE3 staining was 
      identified in 13/45 (29%) cases. The remaining 21 cases were negative stained. In 
      addition, GrCTs in subcutaneous tissue exhibited a relatively higher ratio (8/45, 
      18%) for TFE3 expression, compared with those in other sites. Furthermore, 
      according to FISH data, no rearrangement or amplification of TFE3 was identified 
      in these cases, whether they were positively or negatively stained for TFE3. The 
      results from the present study demonstrated that part of patients GrCTs exhibited 
      TFE3 overexpression, which suggested that this may not be derived from gene 
      rearrangement.
CI  - Copyright: (c) Liu et al.
FAU - Liu, Yang
AU  - Liu Y
AD  - Department of Pathology, The First Affiliated Hospital and College of Basic 
      Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. 
      China.
FAU - Zheng, Qin
AU  - Zheng Q
AD  - Department of Pathology, The First Affiliated Hospital and College of Basic 
      Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. 
      China.
FAU - Wang, Chen
AU  - Wang C
AD  - Department of Pathology, The First Affiliated Hospital and College of Basic 
      Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. 
      China.
FAU - Wang, Jinping
AU  - Wang J
AD  - Department of Pathology, The First Affiliated Hospital and College of Basic 
      Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. 
      China.
FAU - Ming, Jian
AU  - Ming J
AD  - Department of Pathology, The 202nd Hospital of Chinese PLA, Shenyang, Liaoning 
      110003, P.R. China.
FAU - Zhang, Yong
AU  - Zhang Y
AD  - Department of Pathology, Cancer Hospital of China Medical University, Shenyang, 
      Liaoning 110042, P.R. China.
FAU - Li, Xiaoman
AU  - Li X
AD  - Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical 
      University, Shenyang, Liaoning 110001, P.R. China.
FAU - Cho, William Chi-Shing
AU  - Cho WC
AD  - Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong 
      SAR, P.R. China.
FAU - Wang, Liang
AU  - Wang L
AD  - Department of Pathology, The First Affiliated Hospital and College of Basic 
      Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. 
      China.
FAU - Li, Qing-Chang
AU  - Li QC
AD  - Department of Pathology, The First Affiliated Hospital and College of Basic 
      Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. 
      China.
FAU - Qiu, Xue-Shan
AU  - Qiu XS
AD  - Department of Pathology, The First Affiliated Hospital and College of Basic 
      Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. 
      China.
FAU - Wang, En-Hua
AU  - Wang EH
AD  - Department of Pathology, The First Affiliated Hospital and College of Basic 
      Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. 
      China.
LA  - eng
PT  - Journal Article
DEP - 20191017
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6865705
OTO - NOTNLM
OT  - FISH
OT  - TFE3
OT  - gene rearrangement
OT  - granular cell tumor
OT  - immunohistochemistry
EDAT- 2019/12/04 06:00
MHDA- 2019/12/04 06:01
PMCR- 2019/10/17
CRDT- 2019/12/03 06:00
PHST- 2018/12/07 00:00 [received]
PHST- 2019/08/01 00:00 [accepted]
PHST- 2019/12/03 06:00 [entrez]
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2019/12/04 06:01 [medline]
PHST- 2019/10/17 00:00 [pmc-release]
AID - OL-0-0-10995 [pii]
AID - 10.3892/ol.2019.10995 [doi]
PST - ppublish
SO  - Oncol Lett. 2019 Dec;18(6):6355-6360. doi: 10.3892/ol.2019.10995. Epub 2019 Oct 
      17.