PMID- 31789506 OWN - NLM STAT- MEDLINE DCOM- 20201021 LR - 20201021 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 12 IP - 4 DP - 2020 Jan 29 TI - Crystal-Amorphous Core-Shell Structure Synergistically Enabling TiO(2) Nanoparticles' Remarkable SERS Sensitivity for Cancer Cell Imaging. PG - 4204-4211 LID - 10.1021/acsami.9b17150 [doi] AB - Exploring novel surface-enhanced Raman scattering (SERS) active materials with high detection sensitivity, excellent biocompatibility, low biotoxicity, and good spectral stability is urgently required for efficacious cancer cell diagnosis. Herein, black TiO(2) nanoparticles (B-TiO(2) NPs) with crystal-amorphous core-shell structure are successfully developed. Remarkable SERS activity is derived from the synergistic effect of the promising crystal-amorphous core-shell structure. Abundant excitons can be generated by high-efficiency exciton transitions in the crystal core, a feature that provides sufficient charge source. Significantly, the novel crystal-amorphous heterojunction enables the efficient exciton separation at the crystal-amorphous interface, which can effectively facilitate charge transfer from the crystal core to the amorphous shell and results in exciton enrichment at the amorphous shell. Kelvin probe force microscopy (KPFM) confirms the Fermi level of the amorphous layer shifting to a relatively low position compared to that of the crystal core, allowing efficient photoinduced charge transfer (PICT) between the amorphous shell and probe molecules. The first-principles density functional theory (DFT) calculations further indicate that the amorphous shell structure possesses a narrow band gap and a relatively high electronic density of state (DOS), which can effectively promote vibration coupling with target molecules. Moreover, MCF-7 drug-resistant (MCF-7/ADR) breast cancer cells can be quickly and accurately diagnosed based on the high-sensitivity B-TiO(2)-based SERS bioprobe. To the best of our knowledge, this is the first time the crystal-amorphous core-shell heterojunction enhancement of the TiO(2)-molecule PICT process, which widens the application of semiconductor-based SERS platforms in precision diagnosis and treatment of cancer, has been investigated. FAU - Lin, Jie AU - Lin J AD - Cixi Institute of Biomedical Engineering, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering , Chinese Academy of Sciences , 1219 ZhongGuan West Road , Ningbo 315201 , P. R. China. FAU - Ren, Wenzhi AU - Ren W AD - Cixi Institute of Biomedical Engineering, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering , Chinese Academy of Sciences , 1219 ZhongGuan West Road , Ningbo 315201 , P. R. China. FAU - Li, Anran AU - Li A AD - Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology, Ministry of Education, School of Chemistry and Environment , Beihang University , Beijing 100191 , P. R. China. FAU - Yao, Chenyang AU - Yao C AD - Cixi Institute of Biomedical Engineering, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering , Chinese Academy of Sciences , 1219 ZhongGuan West Road , Ningbo 315201 , P. R. China. FAU - Chen, Tianxiang AU - Chen T AD - Cixi Institute of Biomedical Engineering, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering , Chinese Academy of Sciences , 1219 ZhongGuan West Road , Ningbo 315201 , P. R. China. FAU - Ma, Xuehua AU - Ma X AD - Cixi Institute of Biomedical Engineering, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering , Chinese Academy of Sciences , 1219 ZhongGuan West Road , Ningbo 315201 , P. R. China. FAU - Wang, Xiaotian AU - Wang X AD - Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology, Ministry of Education, School of Chemistry and Environment , Beihang University , Beijing 100191 , P. R. China. FAU - Wu, Aiguo AU - Wu A AUID- ORCID: 0000-0001-7200-8923 AD - Cixi Institute of Biomedical Engineering, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering , Chinese Academy of Sciences , 1219 ZhongGuan West Road , Ningbo 315201 , P. R. China. LA - eng PT - Journal Article DEP - 20191212 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 RN - 15FIX9V2JP (titanium dioxide) RN - D1JT611TNE (Titanium) SB - IM MH - Humans MH - MCF-7 Cells MH - Microscopy, Fluorescence MH - Nanoparticles/*chemistry MH - Neoplasms/*metabolism/*pathology MH - *Spectrum Analysis, Raman MH - Titanium/*chemistry OTO - NOTNLM OT - black TiO2 nanoparticles OT - cancer diagnosis and treatment OT - crystal-amorphous core-shell structure OT - photoinduced charge transfer OT - surface-enhanced Raman scattering EDAT- 2019/12/04 06:00 MHDA- 2020/10/22 06:00 CRDT- 2019/12/03 06:00 PHST- 2019/12/04 06:00 [pubmed] PHST- 2020/10/22 06:00 [medline] PHST- 2019/12/03 06:00 [entrez] AID - 10.1021/acsami.9b17150 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2020 Jan 29;12(4):4204-4211. doi: 10.1021/acsami.9b17150. Epub 2019 Dec 12.