PMID- 31789613
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20200420
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 22
IP  - 6
DP  - 2019 Nov
TI  - Prognostic significance of brain-derived neurotrophic factor levels in patients 
      with heart failure and reduced left ventricular ejection fraction.
PG  - 309-316
LID - 10.14744/AnatolJCardiol.2019.37941 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) is a member of the 
      neurotrophin family. The aim of the present study was to investigate the 
      relationship between BDNF levels and prognostic markers in patients with heart 
      failure (HF) and reduced left ventricular ejection fraction (LVEF), considering 
      death or rehospitalization due to HF. METHODS: Patients with severe left 
      ventricular systolic dysfunction (LVEF </=35%) and individuals with no history of 
      cardiac disease (control group) were included in the study conducted between 2013 
      and 2017. Of the included patients, 52 were classified as mildly symptomatic [New 
      York Heart Association (NYHA) I-II], and 108 were classified as severely 
      symptomatic (NYHA III). The control group comprised 50 individuals. The primary 
      endpoints of the study consisted of cardiovascular death during long-term 
      follow-up and hospitalization for worsening of HF. RESULTS: The mean age of the 
      patient group was 67.60+/-11.45 years and 58% were male, whereas that of the 
      control group was 66.28+/-11.30 years and 48% were male. The N-terminal 
      pro-brain-type natriuretic peptide (NT-pro-BNP) serum levels in patients with HF 
      were higher, whereas the BDNF values were lower than those in the control group 
      (NT-pro-BNP: 5010+/-851 pg/mL vs. 33+/-11 pg/mL, p<0.001; BDNF: 8.64+/-1.12 ng/mL vs. 
      17.58+/-4.51 ng/mL, p<0.001). Multivariable analysis suggested that there was a 
      significant association between BDNF levels and clinical status, generating the 
      primary endpoints of death [BDNF levels: Odds ratio (OR)=0.17, 95% confidence 
      interval (CI): 0.05-0.53, p=0.002], and rehospitalization (BDNF levels: OR=0.702, 
      95% CI: 0.54-0.92, p=0.010). CONCLUSION: Decreased serum BDNF levels were 
      associated with death and rehospitalization in patients with HF, suggesting that 
      these levels can be useful prognostic biomarkers.
FAU - Barman, Hasan Ali
AU  - Barman HA
AD  - Department of Cardiology, Okmeydani Training and Research Hospital; 
      Istanbul-Turkey.
FAU - Sahin, Irfan
AU  - Sahin I
AD  - Department of Cardiology, Bagcilar Training and Research Hospital; 
      Istanbul-Turkey.
FAU - Atici, Adem
AU  - Atici A
AD  - Department of Cardiology, Istanbul Gaziosmanpasa Taksim Training and Research 
      Hospital; Istanbul-Turkey.
FAU - Durmaz, Eser
AU  - Durmaz E
AD  - Department of Cardiology, Cerrahpasa Faculty of Medicine, Istanbul University; 
      Istanbul-Turkey.
FAU - Yurtseven, Ece
AU  - Yurtseven E
AD  - Department of Cardiology, Faculty of Medicine, Koc University Hospital; 
      Istanbul-Turkey.
FAU - Ikitimur, Baris
AU  - Ikitimur B
AD  - Department of Cardiology, Cerrahpasa Faculty of Medicine, Istanbul University; 
      Istanbul-Turkey.
FAU - Okuyan, Ertugrul
AU  - Okuyan E
AD  - Department of Cardiology, Bagcilar Training and Research Hospital; 
      Istanbul-Turkey.
FAU - Keles, Ibrahim
AU  - Keles I
AD  - Department of Cardiology, Cerrahpasa Faculty of Medicine, Istanbul University; 
      Istanbul-Turkey.
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
CIN - Anatol J Cardiol. 2019 Nov;22(6):317-318. PMID: 31789615
CIN - Anatol J Cardiol. 2020 Feb;23(3):192. PMID: 32120366
MH  - Aged
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Heart Failure/blood/complications/mortality/*physiopathology
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Survival Analysis
MH  - Turkey
MH  - Ventricular Dysfunction, Left/*complications
PMC - PMC6955046
COIS- Conflict of interest: None declared.
EDAT- 2019/12/04 06:00
MHDA- 2020/04/21 06:00
PMCR- 2019/01/01
CRDT- 2019/12/03 06:00
PHST- 2019/12/03 06:00 [entrez]
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - AJC-22-309 [pii]
AID - 10.14744/AnatolJCardiol.2019.37941 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2019 Nov;22(6):309-316. doi: 
      10.14744/AnatolJCardiol.2019.37941.