PMID- 31789677
OWN - NLM
STAT- MEDLINE
DCOM- 20210616
LR  - 20210616
IS  - 1473-6535 (Electronic)
IS  - 0957-9672 (Linking)
VI  - 31
IP  - 1
DP  - 2020 Feb
TI  - Fatty liver, cardiometabolic disease and mortality.
PG  - 27-31
LID - 10.1097/MOL.0000000000000652 [doi]
AB  - PURPOSE OF REVIEW: We discuss the findings of the most recent metanalyses on the 
      association between nonalcoholic fatty liver disease (NAFLD), cardiometabolic 
      disease and mortality. RECENT FINDINGS: Recent metanalyses have shown that NAFLD 
      is associated with incident type 2 diabetes mellitus (T2DM) and incident 
      cardiovascular disease (CVD). Nonalcoholic steatohepatitis, which can be 
      diagnosed by liver biopsy only in tertiary care centers, is often associated with 
      liver fibrosis, which has been shown by metanalyses to increase both 
      cardiovascular and liver-related mortality. Hyperlipidemia, lipotoxicity and 
      impaired insulin secretion are among the possible mechanisms underlying the 
      association of NAFLD with T2DM and CVD. Metanalyses of the association between 
      NAFLD and mortality in the general population, where risk stratification cannot 
      be performed on the basis of liver biopsy, have given contradictory results. 
      SUMMARY: To establish conclusively whether NAFLD adds to known prognostic factors 
      of death in the general population will require a shared operational definition 
      of NAFLD, purposefully designed cohort studies, and the use of clinically 
      relevant measures of effect size.
FAU - Bedogni, Giorgio
AU  - Bedogni G
AD  - Liver Research Center, Italian Liver Foundation, Basovizza, Trieste.
FAU - Gastaldelli, Amalia
AU  - Gastaldelli A
AD  - Institute of Clinical Physiology, National Research Council, Pisa.
FAU - Foschi, Francesco G
AU  - Foschi FG
AD  - Department of Internal Medicine, Ospedale di Faenza, AUSL Romagna, Faenza, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Lipidol
JT  - Current opinion in lipidology
JID - 9010000
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/metabolism/*mortality/pathology
MH  - Fatty Liver/complications/*mortality
MH  - Humans
MH  - Metabolic Diseases/metabolism/*mortality/pathology
MH  - Risk Factors
MH  - Survival Rate
EDAT- 2019/12/04 06:00
MHDA- 2021/06/17 06:00
CRDT- 2019/12/03 06:00
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2021/06/17 06:00 [medline]
PHST- 2019/12/03 06:00 [entrez]
AID - 00041433-202002000-00006 [pii]
AID - 10.1097/MOL.0000000000000652 [doi]
PST - ppublish
SO  - Curr Opin Lipidol. 2020 Feb;31(1):27-31. doi: 10.1097/MOL.0000000000000652.