PMID- 31790242
OWN - NLM
STAT- MEDLINE
DCOM- 20201008
LR  - 20201008
IS  - 1520-5126 (Electronic)
IS  - 0002-7863 (Linking)
VI  - 141
IP  - 51
DP  - 2019 Dec 26
TI  - Programming Drug Delivery Kinetics for Active Burst Release with DNA Toehold 
      Switches.
PG  - 20354-20364
LID - 10.1021/jacs.9b10765 [doi]
AB  - Despite smart drug delivery systems (DDSs) with high delivery efficiency and 
      improved efficacy for chemotherapy, precise drug release in targeted tumor cells 
      in a controllable way is still challenging. In this work, we develop DNA toehold 
      switch-engineered spherical nucleic acid-templated hydrogel (SNAgel) for on-site 
      active burst release of chemotherapeutic (tumor-killing) drugs in target cancer 
      cells. By designing ligand-specific toehold sequences on hybridization chain 
      reaction (HCR)-generated SNAgel, we realize burst release of payloads with a wide 
      range of t(1/2) ranging from 60.52 to 5.49 min by active dynamic control of the 
      kinetics. The camouflage of SNAgels with compact DNA shell enables 
      elongated/prolonged blood circulation and targeted accumulation, cell entry, and 
      apoptosis induction in vivo. The enhanced anticancer activity of SNAgels was 
      substantiated in both cancer cell lines and xenografted tumor-bearing mice. This 
      DNA-engineered kinetic control approach sheds new light on developing 
      paradigm-shifting DDSs for cancer therapeutics.
FAU - Xiao, Mingshu
AU  - Xiao M
AUID- ORCID: 0000-0003-0673-1544
AD  - Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of 
      Chemistry and Molecular Engineering , East China Normal University , 500 
      Dongchuan Road , Shanghai 200241 , China.
FAU - Lai, Wei
AU  - Lai W
AD  - Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of 
      Chemistry and Molecular Engineering , East China Normal University , 500 
      Dongchuan Road , Shanghai 200241 , China.
FAU - Wang, Fei
AU  - Wang F
AD  - School of Chemistry and Chemical Engineering, and Institute of Molecular 
      Medicine, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , 
      Shanghai 200240 , China.
FAU - Li, Li
AU  - Li L
AUID- ORCID: 0000-0001-8494-4997
AD  - Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of 
      Chemistry and Molecular Engineering , East China Normal University , 500 
      Dongchuan Road , Shanghai 200241 , China.
FAU - Fan, Chunhai
AU  - Fan C
AUID- ORCID: 0000-0002-7171-7338
AD  - School of Chemistry and Chemical Engineering, and Institute of Molecular 
      Medicine, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , 
      Shanghai 200240 , China.
FAU - Pei, Hao
AU  - Pei H
AUID- ORCID: 0000-0002-6885-6708
AD  - Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of 
      Chemistry and Molecular Engineering , East China Normal University , 500 
      Dongchuan Road , Shanghai 200241 , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191212
PL  - United States
TA  - J Am Chem Soc
JT  - Journal of the American Chemical Society
JID - 7503056
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Hydrogels)
RN  - 0 (Ligands)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Antibiotics, Antineoplastic/chemical synthesis/chemistry/*pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cells, Cultured
MH  - DNA, Neoplasm/*chemistry
MH  - Doxorubicin/chemical synthesis/chemistry/*pharmacology
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Drug Screening Assays, Antitumor
MH  - HEK293 Cells
MH  - HeLa Cells
MH  - Humans
MH  - Hydrogels/*chemistry
MH  - Kinetics
MH  - Ligands
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Neoplasms, Experimental/drug therapy/pathology
MH  - Nucleic Acid Amplification Techniques
MH  - Optical Imaging
MH  - Particle Size
MH  - Surface Properties
EDAT- 2019/12/04 06:00
MHDA- 2020/10/09 06:00
CRDT- 2019/12/03 06:00
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2020/10/09 06:00 [medline]
PHST- 2019/12/03 06:00 [entrez]
AID - 10.1021/jacs.9b10765 [doi]
PST - ppublish
SO  - J Am Chem Soc. 2019 Dec 26;141(51):20354-20364. doi: 10.1021/jacs.9b10765. Epub 
      2019 Dec 12.