PMID- 31790349
OWN - NLM
STAT- MEDLINE
DCOM- 20200615
LR  - 20221230
IS  - 1938-4114 (Electronic)
IS  - 1937-1888 (Print)
IS  - 1937-1888 (Linking)
VI  - 80
IP  - 6
DP  - 2019 Nov
TI  - Sex Differences in the Effect of Nucleus Accumbens Volume on Adolescent Drinking: 
      The Mediating Role of Sensation Seeking in the NCANDA Sample.
PG  - 594-601
AB  - OBJECTIVE: In adolescence, sensation seeking is associated with earlier onset of 
      alcohol use, which is a risk factor for a variety of negative consequences later 
      in life. Individual differences in sensation seeking are related to brain 
      function in the nucleus accumbens (NAcc), a brain region that undergoes 
      considerable structural development during adolescence. Therefore, the goal of 
      this study was to determine whether NAcc volume in alcohol-naive adolescents was 
      associated with future sensation seeking and alcohol use and whether these 
      associations differed by sex. METHOD: High-resolution magnetic resonance imaging 
      was used to measure NAcc volume at baseline in 514 alcohol-naive adolescents 
      (50.2% female) from the National Consortium on Alcohol & Neurodevelopment in 
      Adolescence study. Direct effects of NAcc volume on adolescent drinking 2 years 
      after baseline, and indirect effects mediated through sensation seeking 1 year 
      after baseline, were assessed. RESULTS: An indirect effect of NAcc volume on 
      subsequent drinking through sensation seeking was significant for males, but not 
      females. This effect was driven by a positive association between NAcc volume and 
      sensation seeking observed in male, but not female, participants. A direct effect 
      of NAcc volume on subsequent alcohol use was detected in females, but not males. 
      In females, no association between NAcc volume and sensation seeking was 
      detected, but NAcc volume was positively associated with future alcohol use. 
      CONCLUSIONS: These findings suggest that delayed structural maturation of the 
      NAcc may be a risk factor for alcohol use in adolescence; however, the mechanism 
      by which the structure of the NAcc confers risk differs by sex.
FAU - Morales, Angelica M
AU  - Morales AM
AD  - Department of Psychiatry, Oregon Health & Science University, Portland, Oregon.
FAU - Boyd, Stephen J
AU  - Boyd SJ
AD  - Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science 
      University, Portland, Oregon.
FAU - Mackiewicz Seghete, Kristen L
AU  - Mackiewicz Seghete KL
AD  - Department of Psychiatry, Oregon Health & Science University, Portland, Oregon.
FAU - Johnson, Alicia J
AU  - Johnson AJ
AD  - Department of Psychiatry, Oregon Health & Science University, Portland, Oregon.
FAU - De Bellis, Michael D
AU  - De Bellis MD
AD  - Department of Psychiatry & Behavioral Sciences, Duke University School of 
      Medicine, Durham, North Carolina.
FAU - Nagel, Bonnie J
AU  - Nagel BJ
AD  - Department of Psychiatry, Oregon Health & Science University, Portland, Oregon.
AD  - Department of Behavioral Neuroscience, Oregon Health & Science University, 
      Portland, Oregon.
LA  - eng
GR  - U24 AA021697/AA/NIAAA NIH HHS/United States
GR  - U01 AA021696/AA/NIAAA NIH HHS/United States
GR  - U01 AA021691/AA/NIAAA NIH HHS/United States
GR  - U01 AA021681/AA/NIAAA NIH HHS/United States
GR  - U01 AA021695/AA/NIAAA NIH HHS/United States
GR  - U01 AA021692/AA/NIAAA NIH HHS/United States
GR  - U01 AA021690/AA/NIAAA NIH HHS/United States
GR  - U24 AA021695/AA/NIAAA NIH HHS/United States
GR  - U01 AA021697/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Stud Alcohol Drugs
JT  - Journal of studies on alcohol and drugs
JID - 101295847
SB  - IM
MH  - Adolescent
MH  - Alcohol Drinking/*psychology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neuroimaging
MH  - Nucleus Accumbens/*anatomy & histology
MH  - *Risk-Taking
MH  - *Sex Characteristics
MH  - Time Factors
MH  - Underage Drinking/*psychology
PMC - PMC6900990
EDAT- 2019/12/04 06:00
MHDA- 2020/06/17 06:00
PMCR- 2020/11/01
CRDT- 2019/12/03 06:00
PHST- 2019/12/03 06:00 [entrez]
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2020/06/17 06:00 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - 594 [pii]
AID - 10.15288/jsad.2019.80.594 [doi]
PST - ppublish
SO  - J Stud Alcohol Drugs. 2019 Nov;80(6):594-601. doi: 10.15288/jsad.2019.80.594.