PMID- 31790711
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20210920
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 165-166
DP  - 2020
TI  - The blood-brain barrier: Physiology and strategies for drug delivery.
PG  - 1-14
LID - S0169-409X(19)30238-8 [pii]
LID - 10.1016/j.addr.2019.11.009 [doi]
AB  - The blood-brain barrier (BBB) is a dynamic structure that functions as a 
      gatekeeper, reflecting the unique requirements of the brain. In this review, 
      following a brief historical overview of how the concepts of the BBB and the 
      neurovascular unit (NVU) developed, we describe its physiology and architecture, 
      which pose a particular challenge to therapeutic intervention. We then discuss 
      how the restrictive nature of this barrier can be overcome for the delivery of 
      therapeutic agents. Alterations to drug formulation offer one option, in part by 
      utilizing distinct transport modes; another is invasive or non-invasive 
      strategies to bypass the BBB. An emerging non-invasive technology for targeted 
      drug delivery is focused ultrasound that allows for the safe and reversible 
      disruption of the BBB. We discuss the underlying mechanisms and provide an 
      outlook, emphasizing the need for more research into the NVU and investment in 
      innovative technologies to overcome the BBB for drug delivery.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Pandit, Rucha
AU  - Pandit R
AD  - Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The 
      University of Queensland, Brisbane, QLD, Australia.
FAU - Chen, Liyu
AU  - Chen L
AD  - Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The 
      University of Queensland, Brisbane, QLD, Australia.
FAU - Gotz, Jurgen
AU  - Gotz J
AD  - Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The 
      University of Queensland, Brisbane, QLD, Australia. Electronic address: 
      j.goetz@uq.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191129
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
RN  - 0 (ATP-Binding Cassette Transporters)
SB  - IM
MH  - ATP-Binding Cassette Transporters/metabolism
MH  - Biological Transport/physiology
MH  - Blood-Brain Barrier/*physiology
MH  - Drug Administration Routes
MH  - Drug Delivery Systems/*methods
MH  - Endothelial Cells/metabolism
MH  - Exosomes/metabolism
MH  - Humans
MH  - Tight Junctions/metabolism
MH  - Ultrasonic Therapy/*methods
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Blood-brain barrier
OT  - Brain
OT  - Drug delivery
OT  - Endothelial cells
OT  - Focused ultrasound
OT  - Microbubbles
OT  - Tight junctions
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2019/12/04 06:00
MHDA- 2021/09/21 06:00
CRDT- 2019/12/03 06:00
PHST- 2019/09/20 00:00 [received]
PHST- 2019/11/19 00:00 [revised]
PHST- 2019/11/24 00:00 [accepted]
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2019/12/03 06:00 [entrez]
AID - S0169-409X(19)30238-8 [pii]
AID - 10.1016/j.addr.2019.11.009 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2020;165-166:1-14. doi: 10.1016/j.addr.2019.11.009. Epub 2019 
      Nov 29.