PMID- 31791423 OWN - NLM STAT- MEDLINE DCOM- 20201217 LR - 20240324 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) VI - 123 IP - 6 DP - 2020 Mar 28 TI - Urinary flavanone concentrations as biomarkers of dietary flavanone intakes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. PG - 691-698 LID - 10.1017/S0007114519003131 [doi] AB - In the present study, the aim was to investigate the correlation between the acute and habitual dietary intake of flavanones, their main food sources and the concentrations of aglycones naringenin and hesperetin in 24 h urine in a European population. A 24-h dietary recall (24-HDR) and a 24-h urine sample were collected the same day from a subsample of 475 people from four different countries of the European Prospective Investigation into Cancer and Nutrition study. Acute and habitual dietary data were captured through a standardised 24-HDR and a country/centre-specific validated dietary questionnaire (DQ). The intake of dietary flavanones was estimated using the Phenol-Explorer database. Urinary flavanones (naringenin and hesperetin) were analysed using tandem MS with a previous enzymatic hydrolysis. Weak partial correlation coefficients were found between urinary flavanone concentrations and both acute and habitual dietary flavanone intakes (Rpartial = 0.14-0.17). Partial correlations were stronger between urinary excretions and acute intakes of citrus fruit and juices (Rpartial approximately 0.6) than with habitual intakes of citrus fruit and juices (Rpartial approximately 0.24). In conclusion, according to our results, urinary excretion of flavanones can be considered a good biomarker of acute citrus intake. However, low associations between habitual flavanone intake and urinary excretion suggest a possible inaccurate estimation of their intake or a too sporadic intake. For assessing habitual exposures, multiple urinary collections may be needed. These results show that none of the approaches tested is ideal, and the use of both DQ and biomarkers can be recommended. FAU - Tahiri, Iasim AU - Tahiri I AD - Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908Barcelona, Spain. FAU - Garro-Aguilar, Yaiza AU - Garro-Aguilar Y AD - Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908Barcelona, Spain. FAU - Cayssials, Valerie AU - Cayssials V AD - Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908Barcelona, Spain. FAU - Achaintre, David AU - Achaintre D AD - Unit of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), 69008Lyon, France. FAU - Mancini, Francesca Romana AU - Mancini FR AD - UMR 1018/Centre de recherche en Epidemiologie et Sante des Populations (CESP), Fac. de medecine, Univ. Paris-Sud, Fac. de medecine - Universite de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national de la sante et de la recherche medicale (INSERM), Universite Paris-Saclay, 94807Villejuif, France. AD - UMR 1018/Centre de recherche en Epidemiologie et Sante des Populations (CESP), Institut Gustave Roussy, 94805Villejuif, France. FAU - Mahamat-Saleh, Yahya AU - Mahamat-Saleh Y AD - UMR 1018/Centre de recherche en Epidemiologie et Sante des Populations (CESP), Fac. de medecine, Univ. Paris-Sud, Fac. de medecine - Universite de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national de la sante et de la recherche medicale (INSERM), Universite Paris-Saclay, 94807Villejuif, France. AD - UMR 1018/Centre de recherche en Epidemiologie et Sante des Populations (CESP), Institut Gustave Roussy, 94805Villejuif, France. FAU - Boutron-Ruault, Marie-Christine AU - Boutron-Ruault MC AD - UMR 1018/Centre de recherche en Epidemiologie et Sante des Populations (CESP), Fac. de medecine, Univ. Paris-Sud, Fac. de medecine - Universite de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national de la sante et de la recherche medicale (INSERM), Universite Paris-Saclay, 94807Villejuif, France. AD - UMR 1018/Centre de recherche en Epidemiologie et Sante des Populations (CESP), Institut Gustave Roussy, 94805Villejuif, France. FAU - Kuhn, Tilman AU - Kuhn T AD - Division of Cancer Epidemiology, German Cancer Research Center, 69120Heidelberg, Germany. FAU - Katzke, Verena AU - Katzke V AD - Division of Cancer Epidemiology, German Cancer Research Center, 69120Heidelberg, Germany. FAU - Boeing, Heiner AU - Boeing H AD - Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558Nuthetal, Germany. FAU - Trichopoulou, Antonia AU - Trichopoulou A AD - Hellenic Health Foundation, 11527Athens, Greece. FAU - Karakatsani, Anna AU - Karakatsani A AD - Hellenic Health Foundation, 11527Athens, Greece. AD - 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, 12462Haidari, Greece. FAU - Valanou, Elisavet AU - Valanou E AD - Hellenic Health Foundation, 11527Athens, Greece. FAU - Palli, Domenico AU - Palli D AD - Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - Istituto per lo studio, la prevenzione e la rete oncologica (ISPRO), 50139Florence, Italy. FAU - Sieri, Sabina AU - Sieri S AD - Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133Milan, Italy. FAU - Santucci de Magistris, Maria AU - Santucci de Magistris M AD - Dipartimento di Medicina Clinica e Chirurgia, Azienda Ospedaliera Universitaria (AOU) Federico II, 80131Naples, Italy. FAU - Tumino, Rosario AU - Tumino R AD - Cancer Registry and Histopathology Department, "M.P. Arezzzo" Hospital, ASP Ragusa, 97100Ragusa, Italy. FAU - Macciotta, Alessandra AU - Macciotta A AD - Department of Clinical and Biological Sciences, University of Turin, 10124Turin, Italy. FAU - Huybrechts, Inge AU - Huybrechts I AD - Unit of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), 69008Lyon, France. FAU - Agudo, Antonio AU - Agudo A AD - Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908Barcelona, Spain. FAU - Scalbert, Augustin AU - Scalbert A AD - Unit of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), 69008Lyon, France. FAU - Zamora-Ros, Raul AU - Zamora-Ros R AUID- ORCID: 0000-0002-6236-6804 AD - Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908Barcelona, Spain. LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191203 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 RN - 0 (Biomarkers) RN - 0 (Flavanones) RN - E750O06Y6O (Hesperidin) RN - HN5425SBF2 (naringenin) RN - Q9Q3D557F1 (hesperetin) RN - WX22P730FB (flavanone) SB - IM MH - Biomarkers/urine MH - Citrus sinensis MH - *Diet MH - Europe MH - Female MH - Flavanones/*administration & dosage/chemistry/*urine MH - Hesperidin/chemistry/urine MH - Humans MH - Male MH - Middle Aged MH - Nutrition Assessment MH - Nutrition Surveys OTO - NOTNLM OT - Biomarkers OT - European Prospective Investigation into Cancer and Nutrition study OT - Flavanones OT - Intake OT - Urine EDAT- 2019/12/04 06:00 MHDA- 2020/12/18 06:00 CRDT- 2019/12/04 06:00 PHST- 2019/12/04 06:00 [pubmed] PHST- 2020/12/18 06:00 [medline] PHST- 2019/12/04 06:00 [entrez] AID - S0007114519003131 [pii] AID - 10.1017/S0007114519003131 [doi] PST - ppublish SO - Br J Nutr. 2020 Mar 28;123(6):691-698. doi: 10.1017/S0007114519003131. Epub 2019 Dec 3.