PMID- 31791908
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20200804
IS  - 2212-5353 (Electronic)
IS  - 2212-5345 (Linking)
VI  - 58
IP  - 1
DP  - 2020 Jan
TI  - Immune reconstitution inflammatory syndrome in the lung in non-human 
      immunodeficiency virus patients.
PG  - 36-44
LID - S2212-5345(19)30221-7 [pii]
LID - 10.1016/j.resinv.2019.11.001 [doi]
AB  - BACKGROUND: We evaluated immune reconstitution inflammatory syndrome (IRIS) in 
      the lung in non-human immunodeficiency virus (HIV) patients. METHODS: We reviewed 
      articles related to IRIS occurrence in the lung in non-HIV patients using a 
      PubMed search. The keywords used for the search were "immune reconstitution 
      syndrome" and "non-HIV." Only patients with lung involvement were included. Those 
      with suggested IRIS caused by white blood cell recovery were excluded. RESULTS: 
      There were 37 cases of IRIS in the lung in non-HIV patients. Complicating 
      infections included tuberculosis (n = 17), histoplasmosis (n = 9), aspergillosis 
      (n = 5), cryptococcosis (n = 4), and Pneumocystis pneumonia (n = 2). We also 
      evaluated the underlying diseases, IRIS pathogenesis, management, and prognosis. 
      IRIS was most commonly encountered in patients treated with anti-tumor necrosis 
      factor (TNF) antibody who developed disseminated or extrapulmonary tuberculosis, 
      leading to treatment discontinuation. CONCLUSIONS: The diagnosis and management 
      of IRIS in the lung in non-HIV patients should be investigated further, 
      especially in the era of anti-TNF treatment.
CI  - Copyright (c) 2019 The Japanese Respiratory Society. Published by Elsevier B.V. All 
      rights reserved.
FAU - Fujita, Jiro
AU  - Fujita J
AD  - Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate 
      School of Medicine, University of the Ryukyus, Okinawa, 903-0215, Japan. 
      Electronic address: fujita@med.u-ryukyu.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20191129
PL  - Netherlands
TA  - Respir Investig
JT  - Respiratory investigation
JID - 101581124
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - *Immune Reconstitution Inflammatory Syndrome/diagnosis/therapy
MH  - Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - Anti-tumor necrosis factor
OT  - Immune reconstitution inflammatory syndrome
OT  - Lung
OT  - Non-HIV patients
EDAT- 2019/12/04 06:00
MHDA- 2020/08/05 06:00
CRDT- 2019/12/04 06:00
PHST- 2019/09/12 00:00 [received]
PHST- 2019/10/30 00:00 [revised]
PHST- 2019/11/05 00:00 [accepted]
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
PHST- 2019/12/04 06:00 [entrez]
AID - S2212-5345(19)30221-7 [pii]
AID - 10.1016/j.resinv.2019.11.001 [doi]
PST - ppublish
SO  - Respir Investig. 2020 Jan;58(1):36-44. doi: 10.1016/j.resinv.2019.11.001. Epub 
      2019 Nov 29.