PMID- 31792117
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 2373-2822 (Electronic)
IS  - 2373-2822 (Linking)
VI  - 7
IP  - 1
DP  - 2020 Jan/Feb
TI  - Timing Determines Tuning: A Rapid Spatial Transformation in Superior Colliculus 
      Neurons during Reactive Gaze Shifts.
LID - ENEURO.0359-18.2019 [pii]
LID - 10.1523/ENEURO.0359-18.2019 [doi]
AB  - Gaze saccades, rapid shifts of the eyes and head toward a goal, have provided 
      fundamental insights into the neural control of movement. For example, it has 
      been shown that the superior colliculus (SC) transforms a visual target (T) code 
      to future gaze (G) location commands after a memory delay. However, this 
      transformation has not been observed in "reactive" saccades made directly to a 
      stimulus, so its contribution to normal gaze behavior is unclear. Here, we tested 
      this using a quantitative measure of the intermediate codes between T and G, 
      based on variable errors in gaze endpoints. We demonstrate that a rapid spatial 
      transformation occurs within the primate's SC (Macaca mulatta) during reactive 
      saccades, involving a shift in coding from T, through intermediate codes, to G. 
      This spatial shift progressed continuously both across and within cell 
      populations [visual, visuomotor (VM), motor], rather than relaying discretely 
      between populations with fixed spatial codes. These results suggest that the SC 
      produces a rapid, noisy, and distributed transformation that contributes to 
      variable errors in reactive gaze shifts.
CI  - Copyright (c) 2020 Sadeh et al.
FAU - Sadeh, Morteza
AU  - Sadeh M
AD  - York Centre for Vision Research and Vision: Science to Applications (VISTA) 
      Program jdc@yorku.ca morteza.sadeh@gmail.com.
AD  - York Neuroscience Graduate Diploma Program.
AD  - Canadian Action and Perception Network (CAPnet).
AD  - Departments of Psychology, Biology, and Kinesiology and Health Science, York 
      University, Toronto, Ontario M3j 1P3, Canada.
FAU - Sajad, Amirsaman
AU  - Sajad A
AD  - York Centre for Vision Research and Vision: Science to Applications (VISTA) 
      Program.
AD  - York Neuroscience Graduate Diploma Program.
AD  - Canadian Action and Perception Network (CAPnet).
AD  - Departments of Psychology, Biology, and Kinesiology and Health Science, York 
      University, Toronto, Ontario M3j 1P3, Canada.
FAU - Wang, Hongying
AU  - Wang H
AD  - York Centre for Vision Research and Vision: Science to Applications (VISTA) 
      Program.
AD  - Canadian Action and Perception Network (CAPnet).
AD  - Departments of Psychology, Biology, and Kinesiology and Health Science, York 
      University, Toronto, Ontario M3j 1P3, Canada.
FAU - Yan, Xiaogang
AU  - Yan X
AD  - York Centre for Vision Research and Vision: Science to Applications (VISTA) 
      Program.
AD  - Canadian Action and Perception Network (CAPnet).
AD  - Departments of Psychology, Biology, and Kinesiology and Health Science, York 
      University, Toronto, Ontario M3j 1P3, Canada.
FAU - Crawford, John Douglas
AU  - Crawford JD
AD  - York Centre for Vision Research and Vision: Science to Applications (VISTA) 
      Program jdc@yorku.ca morteza.sadeh@gmail.com.
AD  - York Neuroscience Graduate Diploma Program.
AD  - Canadian Action and Perception Network (CAPnet).
AD  - Departments of Psychology, Biology, and Kinesiology and Health Science, York 
      University, Toronto, Ontario M3j 1P3, Canada.
LA  - eng
GR  - Canadian Institute of Health Research/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200103
PL  - United States
TA  - eNeuro
JT  - eNeuro
JID - 101647362
SB  - IM
MH  - Animals
MH  - Fixation, Ocular
MH  - Macaca mulatta
MH  - Memory
MH  - Neurons
MH  - *Saccades
MH  - *Superior Colliculi
PMC - PMC6944480
OTO - NOTNLM
OT  - saccades
OT  - spatial transformation
OT  - superior colliculus
OT  - transformation
OT  - visuomotor
EDAT- 2019/12/04 06:00
MHDA- 2021/06/22 06:00
PMCR- 2020/01/02
CRDT- 2019/12/04 06:00
PHST- 2018/09/03 00:00 [received]
PHST- 2019/10/12 00:00 [revised]
PHST- 2019/10/14 00:00 [accepted]
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/12/04 06:00 [entrez]
PHST- 2020/01/02 00:00 [pmc-release]
AID - ENEURO.0359-18.2019 [pii]
AID - eN-NWR-0359-18 [pii]
AID - 10.1523/ENEURO.0359-18.2019 [doi]
PST - epublish
SO  - eNeuro. 2020 Jan 3;7(1):ENEURO.0359-18.2019. doi: 10.1523/ENEURO.0359-18.2019. 
      Print 2020 Jan/Feb.