PMID- 31792370
OWN - NLM
STAT- MEDLINE
DCOM- 20210507
LR  - 20221207
IS  - 1473-1150 (Electronic)
IS  - 1470-269X (Linking)
VI  - 20
IP  - 3
DP  - 2020 Jun
TI  - HLA-A*02:01 allele is associated with tanshinone-induced cutaneous drug reactions 
      in Chinese population.
PG  - 408-414
LID - 10.1038/s41397-019-0121-1 [doi]
AB  - Tanshinone, a widely used Chinese patent medicine, has been confirmed to have 
      various kinds of pharmacological effects although frequently causing cutaneous 
      adverse drug reactions (cADRs). We aim to identify whether human leukocyte 
      antigen (HLA) class I alleles are associated with tanshinone-induced cADRs in Han 
      Chinese. The association study including 18 patients with tanshinone-induced 
      cADRs, 67 tanshinone-tolerant volunteers, and two general population databases 
      consisted of 10,689 and 169,995 healthy subjects was performed. The frequency of 
      tanshinone-induced cADRs patients carrying HLA-A*02:01 was significantly higher 
      when compared with the general control groups (OR = 6.25, Pc = 7.20 x 10(-5); 
      OR = 7.14, Pc = 8.00 x 10(-6)), and with the tolerant group (OR = 5.09, 
      Pc = 0.024). The molecular docking assay confirmed high affinity of the 
      ingredients of tanshinone towards HLA-A*02:01 (</=-7.5 kcal/mol). The result 
      suggested HLA-A*02:01 may work as a promisingly predictive marker for tanshinone 
      personalized therapy in Han Chinese.
FAU - Zhu, Qinyuan
AU  - Zhu Q
AD  - Department of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong 
      Rd., Jing'an District, Shanghai, China.
FAU - Zhang, Yanzhou
AU  - Zhang Y
AD  - Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, China.
FAU - Xuan, Jiekun
AU  - Xuan J
AD  - School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, China.
FAU - Yang, Fanping
AU  - Yang F
AD  - Department of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong 
      Rd., Jing'an District, Shanghai, China.
FAU - Du, Binbin
AU  - Du B
AD  - Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, China.
FAU - Chen, Sheng-An
AU  - Chen SA
AD  - Department of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong 
      Rd., Jing'an District, Shanghai, China.
FAU - Yan, Sijia
AU  - Yan S
AD  - Children's Hospital and Institutes of Biomedical Sciences, Fudan University, 
      Mingdao building, 131 Dong-an Rd., Xuihui District, Shanghai, China.
FAU - Jiang, Menglin
AU  - Jiang M
AD  - Children's Hospital and Institutes of Biomedical Sciences, Fudan University, 
      Mingdao building, 131 Dong-an Rd., Xuihui District, Shanghai, China.
FAU - Zhu, Huizhong
AU  - Zhu H
AD  - Children's Hospital and Institutes of Biomedical Sciences, Fudan University, 
      Mingdao building, 131 Dong-an Rd., Xuihui District, Shanghai, China.
FAU - Xiong, Hao
AU  - Xiong H
AD  - Department of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong 
      Rd., Jing'an District, Shanghai, China.
FAU - Luo, Xiaoqun
AU  - Luo X
AD  - Department of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong 
      Rd., Jing'an District, Shanghai, China. luoxiaoqun913@126.com.
FAU - Xing, Qinghe
AU  - Xing Q
AD  - Children's Hospital and Institutes of Biomedical Sciences, Fudan University, 
      Mingdao building, 131 Dong-an Rd., Xuihui District, Shanghai, China. 
      xingqinghe@hotmail.com.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191203
PL  - United States
TA  - Pharmacogenomics J
JT  - The pharmacogenomics journal
JID - 101083949
RN  - 0 (Abietanes)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (HLA-A*02:01 antigen)
RN  - 0 (HLA-A2 Antigen)
RN  - 03UUH3J385 (tanshinone)
SB  - IM
MH  - Abietanes/*adverse effects
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Anti-Infective Agents/adverse effects
MH  - Asian People/*genetics
MH  - Drug Eruptions/diagnosis/*genetics
MH  - Female
MH  - Genetic Association Studies/*methods
MH  - HLA-A2 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Docking Simulation/methods
MH  - Population Surveillance/methods
MH  - Young Adult
EDAT- 2019/12/04 06:00
MHDA- 2021/05/08 06:00
CRDT- 2019/12/04 06:00
PHST- 2018/10/24 00:00 [received]
PHST- 2019/11/17 00:00 [accepted]
PHST- 2019/11/11 00:00 [revised]
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2021/05/08 06:00 [medline]
PHST- 2019/12/04 06:00 [entrez]
AID - 10.1038/s41397-019-0121-1 [pii]
AID - 10.1038/s41397-019-0121-1 [doi]
PST - ppublish
SO  - Pharmacogenomics J. 2020 Jun;20(3):408-414. doi: 10.1038/s41397-019-0121-1. Epub 
      2019 Dec 3.