PMID- 31792765
OWN - NLM
STAT- MEDLINE
DCOM- 20201117
LR  - 20201117
IS  - 1568-5608 (Electronic)
IS  - 0925-4692 (Linking)
VI  - 28
IP  - 1
DP  - 2020 Feb
TI  - Modulation of cell signaling pathways by Phyllanthus amarus and its major 
      constituents: potential role in the prevention and treatment of inflammation and 
      cancer.
PG  - 1-18
LID - 10.1007/s10787-019-00671-9 [doi]
AB  - The causal and functional connection between inflammation and cancer has become a 
      subject of much research interest. Modulation of cell signaling pathways, such as 
      those involving mitogen activated protein kinases (MAPKs), nuclear factor kappa beta 
      (NF-kappaB), phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt), and Wnt, 
      and their outcomes play a fundamental role in inflammation and cancer. Activation 
      of these cell signaling pathways can lead to various aspects of cancer-related 
      inflammation. Hence, compounds able to modulate inflammation-related molecular 
      targets are sought after in anticancer drug development programs. In recent 
      years, plant extracts and their metabolites have been documented with potential 
      in the prevention and treatment of cancer and inflammatory ailments. Plants 
      possessing anticancer and anti-inflammatory properties due to their bioactive 
      constituents have been reported to modulate the molecular and cellular pathways 
      which are related to inflammation and cancer. In this review we focus on the 
      flavonoids (astragalin, kaempferol, quercetin, rutin), lignans (phyllanthin, 
      hypophyllanthin, and niranthin), tannins (corilagin, geraniin, ellagic acid, 
      gallic acid), and triterpenes (lupeol, oleanolic acid, ursolic acid) of 
      Phyllanthus amarus, which exert various anticancer and anti-inflammatory 
      activities via perturbation of the NF-kappaB, MAPKs, PI3K/Akt, and Wnt signaling 
      networks. Understanding the underlying mechanisms involved may help future 
      research to develop drug candidates for prevention and new treatment for cancer 
      and inflammatory diseases.
FAU - Harikrishnan, Hemavathy
AU  - Harikrishnan H
AD  - Department of Pharmacology, School of Medicine, Case Western Reserve University, 
      Cleveland, OH, USA.
FAU - Jantan, Ibrahim
AU  - Jantan I
AUID- ORCID: 0000-0001-9066-4780
AD  - School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 
      Lakeside Campus, 47500, Subang Jaya, Selangor, Malaysia. 
      Ibrahim.Jantan@taylors.edu.my.
AD  - Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, 43600 
      UKM, Bangi, Selangor, Malaysia. Ibrahim.Jantan@taylors.edu.my.
FAU - Alagan, Akilandeshwari
AU  - Alagan A
AD  - Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and 
      Technology, Chennai, 600 048, India.
FAU - Haque, Md Areeful
AU  - Haque MA
AD  - Department of Pharmacy, International Islamic University Chittagong, Chittagong, 
      4318, Bangladesh.
LA  - eng
GR  - NH1015D075/Kementerian Pertanian dan Industri Asas Tani Malaysia/
PT  - Journal Article
PT  - Review
DEP - 20191202
PL  - Switzerland
TA  - Inflammopharmacology
JT  - Inflammopharmacology
JID - 9112626
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Humans
MH  - Inflammation/*drug therapy
MH  - Neoplasms/*drug therapy
MH  - Phyllanthus/*chemistry
MH  - Plant Extracts/*pharmacology/*therapeutic use
MH  - Signal Transduction/*drug effects
OTO - NOTNLM
OT  - Anti-inflammation
OT  - Anticancer
OT  - Phyllanthus amarus
OT  - Secondary metabolites
OT  - Signaling pathways
EDAT- 2019/12/04 06:00
MHDA- 2020/11/18 06:00
CRDT- 2019/12/04 06:00
PHST- 2019/08/27 00:00 [received]
PHST- 2019/11/15 00:00 [accepted]
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2019/12/04 06:00 [entrez]
AID - 10.1007/s10787-019-00671-9 [pii]
AID - 10.1007/s10787-019-00671-9 [doi]
PST - ppublish
SO  - Inflammopharmacology. 2020 Feb;28(1):1-18. doi: 10.1007/s10787-019-00671-9. Epub 
      2019 Dec 2.