PMID- 31793113
OWN - NLM
STAT- MEDLINE
DCOM- 20210107
LR  - 20210107
IS  - 1365-2869 (Electronic)
IS  - 0962-1105 (Linking)
VI  - 29
IP  - 5
DP  - 2020 Oct
TI  - Connectivity within the default mode network mediates the association between 
      chronotype and sleep quality.
PG  - e12948
LID - 10.1111/jsr.12948 [doi]
AB  - A late chronotype is associated with poor sleep quality, but the fundamental 
      neural mechanism underlying this association remains unclear. Eyes-open 
      resting-state functional MRI scans were obtained from 87 participants after 
      extended wakefulness, and four subregions of the default mode network were 
      extracted and analysed. Partial correlation analysis revealed that the functional 
      connectivity between the precuneus and the medial prefrontal cortex (mPFC) was 
      significantly correlated both with sleep quality and circadian preference of the 
      participants. Mediation analysis found that the precuneus-mPFC link fully 
      mediated the correlation between chronotype and sleep quality. We concluded that 
      increased neural communication in the midline cores of the default mode network 
      (DMN) may be responsible for the poor sleep quality of late chronotypes. As late 
      chronotypes exhibit vulnerability to many mental disorders, our results can be 
      used to refine pathophysiological models and provide therapy for such 
      psychological disorders.
CI  - (c) 2019 European Sleep Research Society.
FAU - Tian, Yun
AU  - Tian Y
AUID- ORCID: 0000-0002-1337-5579
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing, China.
AD  - Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing, 
      China.
FAU - Chen, Xinyuan
AU  - Chen X
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing, China.
AD  - Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing, 
      China.
FAU - Xu, Dan
AU  - Xu D
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing, China.
AD  - Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing, 
      China.
FAU - Yu, Jing
AU  - Yu J
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing, China.
AD  - Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing, 
      China.
FAU - Lei, Xu
AU  - Lei X
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing, China.
AD  - Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191203
PL  - England
TA  - J Sleep Res
JT  - Journal of sleep research
JID - 9214441
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Default Mode Network/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Sleep Wake Disorders/*physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - chronotype
OT  - default mode network
OT  - rs-fMRI
OT  - sleep quality
EDAT- 2019/12/04 06:00
MHDA- 2021/01/08 06:00
CRDT- 2019/12/04 06:00
PHST- 2019/10/06 00:00 [received]
PHST- 2019/10/16 00:00 [revised]
PHST- 2019/10/28 00:00 [accepted]
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2021/01/08 06:00 [medline]
PHST- 2019/12/04 06:00 [entrez]
AID - 10.1111/jsr.12948 [doi]
PST - ppublish
SO  - J Sleep Res. 2020 Oct;29(5):e12948. doi: 10.1111/jsr.12948. Epub 2019 Dec 3.