PMID- 31793357
OWN - NLM
STAT- MEDLINE
DCOM- 20210318
LR  - 20210318
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 36
IP  - 6
DP  - 2020 Jun
TI  - Metabolic inflexibility in women with polycystic ovary syndrome: a systematic 
      review.
PG  - 501-507
LID - 10.1080/09513590.2019.1698025 [doi]
AB  - Polycystic ovary syndrome (PCOS) is a risk factor for dysglycemia, insulin 
      resistance, and type 2 Diabetes Mellitus (T2DM). Inefficient energy oxidation, 
      metabolic inflexibility, is a marker of blunted metabolism. We conducted a 
      systematic review on metabolic inflexibility in women with PCOS. We searched 
      MEDLINE, EMBASE and Cochrane central (inception-October 2018) for studies 
      evaluating metabolic inflexibility and reporting on changes in Respiratory 
      Quotient (DeltaRQ). We extracted data and assessed quality using The Newcastle-Ottawa 
      Scale. We included five prospective cohort studies (461 women). Three compared 
      PCOS women to unaffected subjects, one to women with obesity or T2DM, and one to 
      adolescent girls; all had medium quality. Three studies showed higher metabolic 
      inflexibility in women with PCOS (DeltaRQ range 0.05-0.098) compared to unaffected 
      subjects. Women with PCOS had similar metabolic inflexibility compared to those 
      with T2DM (DeltaRQ 0.05 +/- 0.03 vs 0.06 +/- 0.04, p = .98) and obesity (p = .06). 
      Inflexibility was higher in hyperandrogenemic women with PCOS (DeltaRQ 0.091 +/- 0.060 
      vs 0.120 +/- 0.010, p = .014). DeltaRQ was lower in PCOS women with insulin resistance 
      vs those with normal insulin sensitivity (0.04 +/- 0.02 vs. 0.07 +/- 0.04, p = .007). 
      In conclusion, women with polycystic ovary syndrome appear to have higher 
      metabolic inflexibility associated with hyperandrogenemia and insulin resistance.
FAU - Rimmer, Michael
AU  - Rimmer M
AD  - MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
FAU - Tan, Bee K
AU  - Tan BK
AD  - Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
FAU - Teede, Helena
AU  - Teede H
AD  - National Health and Medical Research Council Centre for Research Excellence in 
      PCOS, Monash Centre for Health Research and Implementation, Monash University 
      Melbourne, Melbourne, Australia.
AD  - Endocrine and Diabetes Units, Monash Health, Melbourne, Australia.
FAU - Thangaratinam, Shakila
AU  - Thangaratinam S
AD  - Women's Health Research Unit, Barts and the London School of Medicine and 
      Dentistry, Queen Mary University of London, London, UK.
FAU - H Al Wattar, Bassel
AU  - H Al Wattar B
AUID- ORCID: 0000-0001-8287-9271
AD  - Women's Health Research Unit, Barts and the London School of Medicine and 
      Dentistry, Queen Mary University of London, London, UK.
AD  - Warwick Medical School, University of Warwick, Coventry, UK.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20191203
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Diabetes Mellitus, Type 2/complications/epidemiology/metabolism
MH  - Female
MH  - Glucose Intolerance/complications/epidemiology/metabolism
MH  - Humans
MH  - Hyperandrogenism/complications/epidemiology/metabolism
MH  - Insulin Resistance/*physiology
MH  - Metabolic Syndrome/epidemiology/etiology
MH  - Obesity/complications/epidemiology/metabolism
MH  - Polycystic Ovary Syndrome/complications/*epidemiology/*metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Metabolic flexibility
OT  - inflexibility
OT  - polycystic syndrome
OT  - systematic review
EDAT- 2019/12/04 06:00
MHDA- 2021/03/19 06:00
CRDT- 2019/12/04 06:00
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2021/03/19 06:00 [medline]
PHST- 2019/12/04 06:00 [entrez]
AID - 10.1080/09513590.2019.1698025 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2020 Jun;36(6):501-507. doi: 10.1080/09513590.2019.1698025. 
      Epub 2019 Dec 3.