PMID- 31793538
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20200108
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 119
IP  - 10
DP  - 2019
TI  - [An analysis of the structural-topographic interaction of the localization of 
      demyelination and optic nerve lesions in patients with multiple sclerosis].
PG  - 15-21
LID - 10.17116/jnevro201911910115 [doi]
AB  - AIM: To analyze the interaction between the localization of demyelination plaques 
      and damage to the optic nerve in patients with multiple sclerosis (MS). MATERIAL 
      AND METHODS: Fifty-five patients (18 men and 37 women) with a confirmed diagnosis 
      of MS were examined based on magnetic resonance imaging of the brain (MRI) and 
      the conclusion of a neurologist. Four topographic zones of localization of the 
      visual paths were identified: the orbital part of the optic nerve, 
      periventricular white matter, areas of the right and left thalamus, and white 
      matter of the occipital lobe of the big hemispheres. The MRI data were compared 
      with the results of spectral optical coherence tomography (C-OCT) of the same 
      study. RESULTS: The greatest number of demyelination plaques is described in the 
      periventricular white matter of the lateral ventricles, and the smallest number 
      in the white matter of the occipital lobe of the large hemispheres. In patients 
      with optic neuritis (ON), demyelination plaques were also detected in the 
      projection of the orbital part of ON in 18% of cases. A comparison analysis 
      reveals no correlation between the side of optical nerve lesion and the presence 
      of lesions in the projection of the orbital part of ON. The predictive ability of 
      C-OCT of focal changes in the brain in interaction with C-OCT parameters in 
      groups with ON and partial ON atrophy due to MS is not confirmed. CONCLUSION: In 
      all patients with MS, demyelination plaques are detected in the visual analyzer 
      (VA) projection, even with the manifestation of the disease. In the course of MS 
      progression, their total number increases. Localization of focal demyelination 
      processes in MS in the projection VA and the side of the lesion do not have 
      reliably confirmed the interaction with the parameters of the optic disc in 
      accordance with C-OCT. A lesion of the peripheral neuron VA is identified in all 
      patients.
FAU - Ioyleva, E E
AU  - Ioyleva EE
AD  - 'Fedorov National Medical Research Center 'Interdiscuplinary Scientific and 
      Technical Complex 'Eye Microsurgery', Moscow, Russia.
FAU - Krivosheeva, M S
AU  - Krivosheeva MS
AD  - Regonal Hospital, Sergiev Posad, Russia.
FAU - Smirnova, M A
AU  - Smirnova MA
AD  - Moscow Regional Oncology Center, Balashikha, Russia.
LA  - rus
PT  - Journal Article
TT  - Analiz strukturno-topograficheskogo vzaimodeistviia lokalizatsii ochagov 
      demielinizatsii i porazheniia zritel'nogo nerva u patsientov s rasseiannym 
      sklerozom.
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
SB  - IM
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Multiple Sclerosis/complications
MH  - Optic Nerve/diagnostic imaging
MH  - *Optic Neuritis/complications
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - multiple sclerosis
OT  - neurological deficit
OT  - optic nerve
OT  - spectral optical coherent tomography
OT  - visual analyzer
EDAT- 2019/12/04 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/12/04 06:00
PHST- 2019/12/04 06:00 [entrez]
PHST- 2019/12/04 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
AID - 10.17116/jnevro201911910115 [doi]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(10):15-21. doi: 
      10.17116/jnevro201911910115.