PMID- 31795098
OWN - NLM
STAT- MEDLINE
DCOM- 20200414
LR  - 20200414
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 23
DP  - 2019 Nov 28
TI  - Epicardial Adipose Tissue: Clinical Biomarker of Cardio-Metabolic Risk.
LID - 10.3390/ijms20235989 [doi]
LID - 5989
AB  - Epicardial adipose tissue (EAT) is part of the visceral adipose tissue (VAT) that 
      surrounds the heart and it is a quantifiable, modifiable, and multifaceted tissue 
      that has both local and systemic effects. When EAT is enlarged, EAT contributes 
      to atherosclerotic cardiovascular disease (ASCVD) risk and plays a role in the 
      development of metabolic syndrome (MetS). In this review, we will discuss the 
      role of EAT in various facets of MetS, including type 2 diabetes mellitus (T2DM) 
      and insulin resistance. We examine the association between EAT and liver 
      steatosis. We also address the correlations of EAT with HIV therapy and with 
      psoriasis. We discuss racial differences in baseline EAT thickness. We conclude 
      that EAT measurement serves as a powerful potential diagnostic tool in assessing 
      cardiovascular and metabolic risk. Measurement of EAT is made less costly, more 
      convenient, and yet accurate and reliable by transthoracic echocardiography. 
      Furthermore, modification of EAT thickness has therapeutic implications for 
      ASCVD, T2DM, and MetS.
FAU - Villasante Fricke, Alexandra C
AU  - Villasante Fricke AC
AD  - Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
FAU - Iacobellis, Gianluca
AU  - Iacobellis G
AD  - Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
AD  - Clinical Medicine Division of Diabetes, Endocrinology and Metabolism University 
      of Miami, Miller School of Medicine, Miami, FL, USA 1400 NW 10th Ave, Dominion 
      Tower Suite 805-807 Miami, FL 33136, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191128
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Cardiovascular Diseases/epidemiology/*metabolism/pathology
MH  - Humans
MH  - Intra-Abdominal Fat/*metabolism/pathology
MH  - Lipid Metabolism
MH  - Metabolic Syndrome/epidemiology/*metabolism/pathology
MH  - Pericardium/*metabolism/pathology
PMC - PMC6929015
OTO - NOTNLM
OT  - HIV
OT  - atherosclerotic cardiovascular risk
OT  - cardiometabolic risk
OT  - epicardial adipose tissue
OT  - epicardial fat
OT  - metabolic syndrome
OT  - psoriasis
OT  - race
OT  - visceral adipose tissue
COIS- The authors declare no conflicts of interest.
EDAT- 2019/12/05 06:00
MHDA- 2020/04/15 06:00
PMCR- 2019/12/01
CRDT- 2019/12/05 06:00
PHST- 2019/10/30 00:00 [received]
PHST- 2019/11/23 00:00 [revised]
PHST- 2019/11/26 00:00 [accepted]
PHST- 2019/12/05 06:00 [entrez]
PHST- 2019/12/05 06:00 [pubmed]
PHST- 2020/04/15 06:00 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - ijms20235989 [pii]
AID - ijms-20-05989 [pii]
AID - 10.3390/ijms20235989 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Nov 28;20(23):5989. doi: 10.3390/ijms20235989.