PMID- 31795253
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 11
IP  - 12
DP  - 2019 Nov 28
TI  - Metal-Phenolic Network-Coated Hyaluronic Acid Nanoparticles for pH-Responsive 
      Drug Delivery.
LID - 10.3390/pharmaceutics11120636 [doi]
LID - 636
AB  - Although self-assembled nanoparticles (SNPs) have been used extensively for 
      targeted drug delivery, their clinical applications have been limited since most 
      of the drugs are released into the blood before they reach their target site. In 
      this study, metal-phenolic network (MPN)-coated SNPs (MPN-SNPs), which consist of 
      an amphiphilic hyaluronic acid derivative, were prepared to be a pH-responsive 
      nanocarrier to facilitate drug release in tumor microenvironments (TME). Due to 
      their amphiphilic nature, SNPs were capable of encapsulating doxorubicin (DOX), 
      chosen as the model anticancer drug. Tannic acid and FeCl(3) were added to the 
      surface of the DOX-SNPs, which allowed them to be readily coated with MPNs as the 
      diffusion barrier. The pH-sensitive MPN corona allowed for a rapid release of DOX 
      and effective cellular SNP uptake in the mildly acidic condition (pH 6.5) 
      mimicking TME, to which the hyaluronic acid was exposed to facilitate 
      receptor-mediated endocytosis. The DOX-loaded MPN-SNPs exhibited a higher 
      cytotoxicity for the cancer cells, suggesting their potential use as a drug 
      carrier in targeted cancer therapy.
FAU - Shin, Jung Min
AU  - Shin JM
AD  - School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 
      Suwon 16419, Korea.
FAU - Choi, Gwan Hyun
AU  - Choi GH
AD  - School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 
      Suwon 16419, Korea.
FAU - Song, Seok Ho
AU  - Song SH
AD  - School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 
      Suwon 16419, Korea.
FAU - Ko, Hyewon
AU  - Ko H
AD  - School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 
      Suwon 16419, Korea.
FAU - Lee, Eun Sook
AU  - Lee ES
AD  - Department of Health Science and Technology, SAIHST, Sungkyunkwan University, 
      Suwon 16419, Korea.
FAU - Lee, Jae Ah
AU  - Lee JA
AD  - School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 
      Suwon 16419, Korea.
FAU - Yoo, Pil J
AU  - Yoo PJ
AD  - School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 
      Suwon 16419, Korea.
AD  - SKKU Advanced Institute of Nanotechnology, SAINT, Sungkyunkwan University, Suwon 
      16419, Korea.
FAU - Park, Jae Hyung
AU  - Park JH
AD  - School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 
      Suwon 16419, Korea.
AD  - Department of Health Science and Technology, SAIHST, Sungkyunkwan University, 
      Suwon 16419, Korea.
AD  - Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 
      16419, Korea.
LA  - eng
GR  - 20100027955/National Research Foundation of Korea/
GR  - 2018R1A2B3006080/National Research Foundation of Korea/
GR  - 2018R1D1A1B07046908/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20191128
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC6956368
OTO - NOTNLM
OT  - drug delivery
OT  - hyaluronic acid
OT  - metal-phenolic network
OT  - pH-responsive particle
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/05 06:00
MHDA- 2019/12/05 06:01
PMCR- 2019/12/01
CRDT- 2019/12/05 06:00
PHST- 2019/09/30 00:00 [received]
PHST- 2019/11/24 00:00 [revised]
PHST- 2019/11/26 00:00 [accepted]
PHST- 2019/12/05 06:00 [entrez]
PHST- 2019/12/05 06:00 [pubmed]
PHST- 2019/12/05 06:01 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - pharmaceutics11120636 [pii]
AID - pharmaceutics-11-00636 [pii]
AID - 10.3390/pharmaceutics11120636 [doi]
PST - epublish
SO  - Pharmaceutics. 2019 Nov 28;11(12):636. doi: 10.3390/pharmaceutics11120636.