PMID- 31796984
OWN - NLM
STAT- MEDLINE
DCOM- 20201214
LR  - 20201214
IS  - 1432-1920 (Electronic)
IS  - 0028-3940 (Linking)
VI  - 62
IP  - 3
DP  - 2020 Mar
TI  - Carotid artery stenosis and brain connectivity: the role of white matter 
      hyperintensities.
PG  - 377-387
LID - 10.1007/s00234-019-02327-5 [doi]
AB  - PURPOSE: It is under debate how white matter hyperintensities (WMH) affects the 
      brain connectivity. The objective of this research study is to validate the 
      hypothesis, if and how the WMH influences brain connectivity in a population with 
      carotid artery stenosis (CAS), which are eligible for carotid endarterectomy 
      (CEA). We used resting state functional connectivity (rs-fc) magnetic resonance 
      (MR) to validate our hypothesis, focusing on the effects of the total number of 
      WMH (TNWMH) and of the WMH Burden (WMHB). METHODS: Twenty-three patients (sixteen 
      males and seven females, mean age 74.34 years) with mono or bilateral carotid 
      stenosis eligible for carotid endarterectomy (CEA), underwent an MR examination 
      on a 1.5-T scanner. The protocol included a morphologic T1-3D isotropic, an EPI 
      functional sequence for rs-fc MR analysis, and a 3D isotropic FLAIR sequence. For 
      each patient, the TNWMH and the WMHB were obtained using two online 
      tools-volBrain and lesionBrain. The rs-fc region-of-interest to 
      region-of-interest (ROI-to-ROI) analysis was performed with the CONN toolbox 
      v18a: two different multiple regression analyses including both WMHB and TNWMH as 
      second-level covariates evaluated the individual effects of WMHB (Analysis A) and 
      TNWMH (Analysis B), adopting a p value corrected for false discovery rate 
      (p-FDR) < 0.05 to identify statistically significant values. RESULTS: Both 
      analyses A and B identified several statistically significant positive and 
      negative correlations associated with WMHB and TNWMH. CONCLUSION: WMH influence 
      functional connectivity in patients with carotid artery stenosis eligible for 
      CEA; further, WMHB and TNWMH influence differently functional connectivity.
FAU - Porcu, Michele
AU  - Porcu M
AUID- ORCID: 0000-0002-3090-8541
AD  - Department of Medical Imaging, AOU of Cagliari, University of Cagliari, S.S: 554, 
      km 4,500, 09042, Monserrato (Cagliari), Italy. micheleporcu87@gmail.com.
FAU - Garofalo, Paolo
AU  - Garofalo P
AD  - Department of Medical Imaging, AOU of Cagliari, University of Cagliari, S.S: 554, 
      km 4,500, 09042, Monserrato (Cagliari), Italy.
FAU - Craboledda, Davide
AU  - Craboledda D
AD  - Department of Vascular Surgery, AOU of Cagliari, University of Cagliari, S.S: 
      554, km 4,500, 09042, Monserrato (Cagliari), Italy.
FAU - Suri, Jasjit S
AU  - Suri JS
AD  - Diagnostic and Monitoring Division, AtheroPoint, Roseville, CA, USA.
FAU - Suri, Harman S
AU  - Suri HS
AD  - Brown University, Providence, RI, USA.
FAU - Montisci, Roberto
AU  - Montisci R
AD  - Department of Vascular Surgery, AOU of Cagliari, University of Cagliari, S.S: 
      554, km 4,500, 09042, Monserrato (Cagliari), Italy.
FAU - Sanfilippo, Roberto
AU  - Sanfilippo R
AD  - Department of Vascular Surgery, AOU of Cagliari, University of Cagliari, S.S: 
      554, km 4,500, 09042, Monserrato (Cagliari), Italy.
FAU - Saba, Luca
AU  - Saba L
AD  - Department of Medical Imaging, AOU of Cagliari, University of Cagliari, S.S: 554, 
      km 4,500, 09042, Monserrato (Cagliari), Italy.
LA  - eng
PT  - Journal Article
DEP - 20191203
PL  - Germany
TA  - Neuroradiology
JT  - Neuroradiology
JID - 1302751
SB  - IM
MH  - Aged
MH  - Carotid Stenosis/*complications
MH  - *Connectome
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - White Matter/*diagnostic imaging
OTO - NOTNLM
OT  - Carotid endarterectomy
OT  - Graph theory
OT  - White matter hyperintensities
OT  - rs-fcMR
EDAT- 2019/12/05 06:00
MHDA- 2020/12/15 06:00
CRDT- 2019/12/05 06:00
PHST- 2019/08/28 00:00 [received]
PHST- 2019/11/18 00:00 [accepted]
PHST- 2019/12/05 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/12/05 06:00 [entrez]
AID - 10.1007/s00234-019-02327-5 [pii]
AID - 10.1007/s00234-019-02327-5 [doi]
PST - ppublish
SO  - Neuroradiology. 2020 Mar;62(3):377-387. doi: 10.1007/s00234-019-02327-5. Epub 
      2019 Dec 3.