PMID- 31798531
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200310
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 10
DP  - 2019
TI  - Effect of Maternal Advanced Endometriosis on Risk of Congenital Malformations for 
      Infants Born After in vitro Fertilization and Frozen-Thawed Embryo Transfer: 
      Analysis of 28,600 Newborns.
PG  - 763
LID - 10.3389/fendo.2019.00763 [doi]
LID - 763
AB  - Background: Endometriosis is one of the most challenging diseases for doctors 
      helping infertile women conceive, which has become a common method to help 
      maternal endometriosis-associated infertility. Women with advanced endometriosis 
      possess a higher risk of several adverse outcomes both during pregnancy and at 
      the time of delivery. Whether endometriosis gives rise to a higher occurrence of 
      congenital abnormalities in infants via in vitro fertilization and frozen-thawed 
      embryo transfer (IVF-ET) remains unknown. Methods: Data collected on 22,865 women 
      undergoing IVF using a freeze-all strategy from 2007 to 2017 were analyzed to 
      estimate the rate of congenital malformations. We used an adjusted OR to compare 
      the fertility outcomes of women with advanced endometriosis to the control group. 
      Results: We studied 1,495 infants born from women with advanced endometriosis and 
      27,105 infants born from endometriosis-free women. There was a 1.557-fold risk 
      that the infants with advanced maternal endometriosis would develop a congenital 
      malformation (adjusted OR: 1.557, 95% CI: 1.03-2.35). Compared with singletons, 
      twins were 1.957 times more likely to experience an adverse outcome (OR: 1.957, 
      95% CI: 1.561-2.455). When analyzing specific categories of birth defects, the 
      proportion of circulatory system defects was higher than the other categories of 
      birth defects in total (0.56%), followed by musculoskeletal system defects 
      (0.15%). Conclusions: Maternal advanced endometriosis might increase the risk of 
      congenital malformations for infants born after IVF-ET. The organ system most 
      frequently affected by congenital malformations was the cardiovascular system, 
      followed by the musculoskeletal system.
CI  - Copyright (c) 2019 Liang, Yin, Ma, Wang and Kuang.
FAU - Liang, Zhou
AU  - Liang Z
AD  - Department of Assisted Reproduction, Shanghai Ninth People's Hospital, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, China.
FAU - Yin, Mingru
AU  - Yin M
AD  - Department of Assisted Reproduction, Shanghai Ninth People's Hospital, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, China.
FAU - Ma, Meng
AU  - Ma M
AD  - Department of Assisted Reproduction, Shanghai Ninth People's Hospital, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, China.
FAU - Wang, Yun
AU  - Wang Y
AD  - Department of Assisted Reproduction, Shanghai Ninth People's Hospital, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, China.
FAU - Kuang, Yanping
AU  - Kuang Y
AD  - Department of Assisted Reproduction, Shanghai Ninth People's Hospital, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20191112
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6863141
OTO - NOTNLM
OT  - IVF
OT  - congenital
OT  - endometriosis
OT  - frozen-thawed embryo transfer
OT  - malformation
EDAT- 2019/12/05 06:00
MHDA- 2019/12/05 06:01
PMCR- 2019/01/01
CRDT- 2019/12/05 06:00
PHST- 2019/07/21 00:00 [received]
PHST- 2019/10/21 00:00 [accepted]
PHST- 2019/12/05 06:00 [entrez]
PHST- 2019/12/05 06:00 [pubmed]
PHST- 2019/12/05 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2019.00763 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2019 Nov 12;10:763. doi: 10.3389/fendo.2019.00763. 
      eCollection 2019.