PMID- 31799224
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 7
DP  - 2019
TI  - Echovirus Type 7 Virus-Associated Hemophagocytic Syndrome in a Neonate 
      Successfully Treated With Intravenous Immunoglobulin Therapy: A Case Report.
PG  - 469
LID - 10.3389/fped.2019.00469 [doi]
LID - 469
AB  - Virus-associated hemophagocytic syndrome (VAHS) in the neonatal period has a high 
      mortality. Although clear diagnostic criteria and treatment methods have not been 
      established, early diagnosis and treatment are critical. However, treatments for 
      VAHS have potentially serious side effects, especially during the neonatal 
      period. Echovirus type 7 can cause maternal infection around parturition and be 
      vertically transmitted to the neonate and induce VAHS. Intravenous immunoglobulin 
      (IVIG) therapy could be a first-line therapy for neonatal VAHS, so that 
      treatments with potentially serious side effects, including cyclosporine A and 
      etoposide, could be avoided. A case of VAHS associated with echovirus type 7 that 
      was successfully treated with IVIG therapy is reported.
CI  - Copyright (c) 2019 Watanabe, Sugiura, Sugimoto, Togawa, Kouwaki, Koyama and Saitoh.
FAU - Watanabe, Yuka
AU  - Watanabe Y
AD  - Department of Pediatrics, Toyohashi Municipal Hospital, Toyohashi, Japan.
FAU - Sugiura, Takahiro
AU  - Sugiura T
AD  - Department of Pediatrics, Toyohashi Municipal Hospital, Toyohashi, Japan.
FAU - Sugimoto, Mari
AU  - Sugimoto M
AD  - Department of Pediatrics, Toyohashi Municipal Hospital, Toyohashi, Japan.
FAU - Togawa, Yasuko
AU  - Togawa Y
AD  - Department of Pediatrics, Toyohashi Municipal Hospital, Toyohashi, Japan.
FAU - Kouwaki, Masanori
AU  - Kouwaki M
AD  - Department of Pediatrics, Toyohashi Municipal Hospital, Toyohashi, Japan.
FAU - Koyama, Norihisa
AU  - Koyama N
AD  - Department of Pediatrics, Toyohashi Municipal Hospital, Toyohashi, Japan.
FAU - Saitoh, Shinji
AU  - Saitoh S
AD  - Department of Pediatrics and Neonatology, Nagoya City University Graduate School 
      of Medical Sciences, Nagoya, Japan.
LA  - eng
PT  - Case Reports
DEP - 20191114
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC6867993
OTO - NOTNLM
OT  - echovirus infections
OT  - hemophagocytic lymphohistiocytosis
OT  - intravenous immunoglobulin therapy
OT  - newborn
OT  - vertical transmission
EDAT- 2019/12/05 06:00
MHDA- 2019/12/05 06:01
PMCR- 2019/11/14
CRDT- 2019/12/05 06:00
PHST- 2019/07/24 00:00 [received]
PHST- 2019/10/28 00:00 [accepted]
PHST- 2019/12/05 06:00 [entrez]
PHST- 2019/12/05 06:00 [pubmed]
PHST- 2019/12/05 06:01 [medline]
PHST- 2019/11/14 00:00 [pmc-release]
AID - 10.3389/fped.2019.00469 [doi]
PST - epublish
SO  - Front Pediatr. 2019 Nov 14;7:469. doi: 10.3389/fped.2019.00469. eCollection 2019.