PMID- 31799866
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20200427
IS  - 1546-3141 (Electronic)
IS  - 0361-803X (Linking)
VI  - 214
IP  - 2
DP  - 2020 Feb
TI  - Diagnostic Value of Whole-Body DWI With Background Body Suppression Plus 
      Calculation of Apparent Diffusion Coefficient at 3 T Versus (18)F-FDG PET/CT for 
      Detection of Bone Metastases.
PG  - 446-454
LID - 10.2214/AJR.19.21656 [doi]
AB  - OBJECTIVE. The purpose of this study is to evaluate the diagnostic performance of 
      whole-body (WB) DWI with background body suppression (DWIBS) combined with 
      calculation of the apparent diffusion coefficient (ADC) value at 3 T compared 
      with the diagnostic performance of (18)F-FDG PET/CT for detecting bone metastases 
      in patients with malignant tumors. SUBJECTS AND METHODS. Thirty-nine consecutive 
      patients with suspected bone metastases underwent both WB DWIBS and FDG PET/CT. 
      Imaging findings were independently interpreted using qualitative and 
      quantitative analyses. Pathologic findings or clinical or radiologic follow-up 
      data were used as the diagnostic reference standard. The sensitivity, 
      specificity, overall accuracy, positive predictive value, and negative predictive 
      value of both modalities were calculated. The ADCs of benign lesions and 
      metastases were compared. RESULTS. A total of 213 metastatic bone segments were 
      confirmed among 39 patients. The sensitivity, specificity, overall accuracy, 
      positive predictive value, and negative predictive value were 93.0%, 87.8%, 
      89.6%, 79.8%, and 96.0%, respectively, for WB DWIBS and 92.5%, 92.0%, 92.1%, 
      85.7% and 95.9%, respectively, for FDG PET/CT. The specificity of WB DWIBS in 
      detecting bone metastases was significantly lower than that of FDG PET/CT (p < 
      0.05), whereas the sensitivity, overall accuracy, positive predictive value, and 
      negative predictive value in detecting bone metastases were not significantly 
      different between WB DWIBS and FDG PET/CT (p > 0.05). The ADCs for benign lesions 
      were significantly higher than those for metastases (p < 0.001). In ROC curve 
      analysis, the AUC value was 0.901. A cutoff ADC value of 920.5 x 10(-6) 
      mm(2)s(-1) distinguished benign lesions from bone metastases with a sensitivity 
      of 92.9% and a specificity of 73.4%. CONCLUSION. WB DWIBS coupled with ADC 
      analysis at 3 T is effective for detecting bone metastases.
FAU - Sun, Wenping
AU  - Sun W
AD  - Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong 
      University Affiliated Sixth People's Hospital, 600, Yishan Rd, Shanghai, 200233, 
      China.
FAU - Li, Mei
AU  - Li M
AD  - Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong 
      University Affiliated Sixth People's Hospital, 600, Yishan Rd, Shanghai, 200233, 
      China.
FAU - Gu, Yifeng
AU  - Gu Y
AD  - Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong 
      University Affiliated Sixth People's Hospital, 600, Yishan Rd, Shanghai, 200233, 
      China.
FAU - Sun, Zhenkui
AU  - Sun Z
AD  - Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai, China.
FAU - Qiu, Zhongling
AU  - Qiu Z
AD  - Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai, China.
FAU - Zhou, Yiyi
AU  - Zhou Y
AD  - Department of Internal Oncology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191204
PL  - United States
TA  - AJR Am J Roentgenol
JT  - AJR. American journal of roentgenology
JID - 7708173
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Neoplasms/*diagnostic imaging/*secondary
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Positron Emission Tomography Computed Tomography/*methods
MH  - Predictive Value of Tests
MH  - Radiopharmaceuticals
MH  - Sensitivity and Specificity
MH  - Whole Body Imaging/*methods
OTO - NOTNLM
OT  - 18F-FDG PET/CT
OT  - DWI
OT  - apparent diffusion coefficient
OT  - bone metastasis
OT  - whole-body MRI
EDAT- 2019/12/05 06:00
MHDA- 2020/04/28 06:00
CRDT- 2019/12/05 06:00
PHST- 2019/12/05 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
PHST- 2019/12/05 06:00 [entrez]
AID - 10.2214/AJR.19.21656 [doi]
PST - ppublish
SO  - AJR Am J Roentgenol. 2020 Feb;214(2):446-454. doi: 10.2214/AJR.19.21656. Epub 
      2019 Dec 4.