PMID- 31800372
OWN - NLM
STAT- MEDLINE
DCOM- 20200731
LR  - 20200731
IS  - 1557-8976 (Electronic)
IS  - 0882-8245 (Linking)
VI  - 32
IP  - 10
DP  - 2019 Dec
TI  - Association of HLA-A, -B, DRB, and DQB Alleles with Persistent HPV-16 Infection 
      in Women from Tamil Nadu, India.
PG  - 430-441
LID - 10.1089/vim.2019.0094 [doi]
AB  - Women with persistent human papillomavirus (HPV) infections have a high risk of 
      developing cervical cancer (CaCx). HPV-16 alone accounts for more than 60% of 
      CaCx worldwide. Most of the HPV infections are transient and only a subset of 
      women develop persistent HPV-16 infection. Many studies have shown associations 
      of different human leukocyte antigen (HLA) alleles with HPV-mediated CaCx, but 
      there are only a few studies globally that relate to persistent HPV-16 infection. 
      Furthermore, such studies from India are sparse. Hence, we investigated the 
      association of HLA-A, B, DRB, and DQB alleles with persistent HPV-16 infection 
      and HPV-16-positive CaCx in south India (Tamil Nadu). HPV-16 persistent infection 
      was observed in 7% of normal women. A total of 50 women with HPV-16-positive 
      CaCx, 21 women with HPV-16 persistent infection, and 74 HPV-16-negative normal 
      women were recruited for this study. Low-resolution typing of HLA-A, B, DRB, and 
      DQB alleles was performed. HLA-B*44 and DRB1*07 showed a significant association 
      with persistent HPV-16 infection (odds ratio, p-value = 26.3, 0.03 and 4.7, 0.01, 
      respectively). HLA-B*27 and DRB1*12 were significantly associated with both 
      HPV-16(+) CaCx and persistent HPV-16 infection (23.8, 0.03; 52.9, 0.01; 9.8, 
      0.0009; and 13.8, 0.009; respectively). HLA-B*15 showed a negative association 
      with HPV-16-positive CaCx (0.1, 0.01), whereas DRB1*04 exhibited protection to 
      both HPV-16-positive CaCx and persistent HPV-16 infection (0.3, 0.0001 and 0.1, 
      0.0002, respectively). Thus, we show HLA allelic association with HPV-16 
      infection in Tamil Nadu. Larger studies on high-resolution HLA typing coupled 
      with HPV-16 genome diversity will offer further insights into host/pathogen 
      genome coevolution.
FAU - Bhaskaran, Muthumeenakshi
AU  - Bhaskaran M
AD  - Human Genomics Laboratory, Centre for Research in Infectious Disease (CRID), 
      School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
FAU - Murali, Sree Varshini
AU  - Murali SV
AD  - Human Genomics Laboratory, Centre for Research in Infectious Disease (CRID), 
      School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
FAU - Rajaram, Barathi
AU  - Rajaram B
AD  - Human Genomics Laboratory, Centre for Research in Infectious Disease (CRID), 
      School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
FAU - Krishnasamy, Sundar
AU  - Krishnasamy S
AD  - Human Genomics Laboratory, Centre for Research in Infectious Disease (CRID), 
      School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
FAU - Devasena, C S
AU  - Devasena CS
AD  - Department of Obstetrics and Gynaecology, Kovai Medical Centre and Hospital, 
      Coimbatore, India.
FAU - Pathak, Atima
AU  - Pathak A
AD  - Department of Obstetrics and Gynaecology, Kovai Medical Centre and Hospital, 
      Coimbatore, India.
FAU - Ravi, Vidhya
AU  - Ravi V
AD  - Department of Obstetrics and Gynaecology, K.A.P. Viswanatham, Government Medical 
      College, Tiruchirapalli, India.
FAU - Swaminathan, Krishnan
AU  - Swaminathan K
AD  - Department of Endocrinology, Kovai Medical Centre and Hospital and Research 
      Foundation, Coimbatore, India.
FAU - Ayyappa, Ashok
AU  - Ayyappa A
AD  - Human Genomics Laboratory, Centre for Research in Infectious Disease (CRID), 
      School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
FAU - Vedhantham, Srinivasan
AU  - Vedhantham S
AD  - Division of R&D, MedGenome Labs Ltd., Bengaluru, India.
FAU - Seshachalam, Arun
AU  - Seshachalam A
AD  - Department of Medical Oncology, GVN Hospital Ltd., Tiruchirapalli, India.
FAU - ArunKumar, GaneshPrasad
AU  - ArunKumar G
AD  - Human Genomics Laboratory, Centre for Research in Infectious Disease (CRID), 
      School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20191203
PL  - United States
TA  - Viral Immunol
JT  - Viral immunology
JID - 8801552
RN  - 0 (DNA, Viral)
RN  - 0 (HLA-D Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Cervix Uteri/immunology/virology
MH  - DNA, Viral/isolation & purification
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-D Antigens/*genetics/immunology
MH  - Haplotypes/immunology
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Host-Pathogen Interactions/genetics/immunology
MH  - Human papillomavirus 16/genetics/*immunology/isolation & purification
MH  - Humans
MH  - India
MH  - Middle Aged
MH  - Papillomavirus Infections/*genetics/immunology/virology
MH  - Polymorphism, Genetic
MH  - Uterine Cervical Neoplasms/*genetics/immunology/virology
MH  - Young Adult
OTO - NOTNLM
OT  - HLA
OT  - HPV-16
OT  - association studies
OT  - cervical cancer
OT  - persistent infection
EDAT- 2019/12/05 06:00
MHDA- 2020/08/01 06:00
CRDT- 2019/12/05 06:00
PHST- 2019/12/05 06:00 [pubmed]
PHST- 2020/08/01 06:00 [medline]
PHST- 2019/12/05 06:00 [entrez]
AID - 10.1089/vim.2019.0094 [doi]
PST - ppublish
SO  - Viral Immunol. 2019 Dec;32(10):430-441. doi: 10.1089/vim.2019.0094. Epub 2019 Dec 
      3.