PMID- 31801268
OWN - NLM
STAT- MEDLINE
DCOM- 20201005
LR  - 20231104
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 11
IP  - 12
DP  - 2019 Nov 30
TI  - Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species.
LID - 10.3390/v11121108 [doi]
LID - 1108
AB  - Viruses of the genus Roseolovirus belong to the subfamily Betaherpesvirinae, 
      family Herpesviridae. Roseoloviruses have been studied in humans, mice and pigs, 
      but they are likely also present in other species. This is the first comparative 
      analysis of roseoloviruses in humans and animals. The human roseoloviruses human 
      herpesvirus 6A (HHV-6A), 6B (HHV-6B), and 7 (HHV-7) are relatively well 
      characterized. In contrast, little is known about the murine roseolovirus (MRV), 
      also known as murine thymic virus (MTV) or murine thymic lymphotrophic virus 
      (MTLV), and the porcine roseolovirus (PRV), initially incorrectly named porcine 
      cytomegalovirus (PCMV). Human roseoloviruses have gained attention because they 
      can cause severe diseases including encephalitis in immunocompromised transplant 
      and AIDS patients and febrile seizures in infants. They have been linked to a 
      number of neurological diseases in the immunocompetent including multiple 
      sclerosis (MS) and Alzheimer's. However, to prove the causality in the latter 
      disease associations is challenging due to the high prevalence of these viruses 
      in the human population. PCMV/PRV has attracted attention because it may be 
      transmitted and pose a risk in xenotransplantation, e.g., the transplantation of 
      pig organs into humans. Most importantly, all roseoloviruses are 
      immunosuppressive, the humoral and cellular immune responses against these 
      viruses are not well studied and vaccines as well as effective antivirals are not 
      available.
FAU - Denner, Joachim
AU  - Denner J
AD  - Robert Koch Institute, Robert Koch Fellow, 13352 Berlin, Germany.
FAU - Bigley, Tarin M
AU  - Bigley TM
AD  - Division of Rheumatology, Department. of Medicine, Washington University School 
      of Medicine, St. Louis, MO 63110, USA.
FAU - Phan, Tuan L
AU  - Phan TL
AD  - Department of Microbiology and Immunology, Tulane University School of Medicine, 
      New Orleans, LA 70118, USA.
AD  - HHV-6 Foundation, Santa Barbara, CA 93108, USA.
FAU - Zimmermann, Cosima
AU  - Zimmermann C
AD  - Institute of Virology, Freie Universitat Berlin, 14163 Berlin, Germany.
FAU - Zhou, Xiaofeng
AU  - Zhou X
AD  - Division of Pulmonary and Critical Care Medicine, Department. of Internal 
      Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
FAU - Kaufer, Benedikt B
AU  - Kaufer BB
AD  - Institute of Virology, Freie Universitat Berlin, 14163 Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191130
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/therapeutic use
MH  - Genome, Viral/*genetics
MH  - Humans
MH  - Mice
MH  - Roseolovirus/genetics/immunology/pathogenicity/*physiology
MH  - Roseolovirus Infections/drug therapy/epidemiology/transmission/*virology
MH  - Swine
MH  - Virus Integration
MH  - Virus Latency
PMC - PMC6949924
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - herpesviruses
OT  - human herpesvirus 6
OT  - human herpesvirus 7
OT  - murine roseolovirus
OT  - porcine cytomegalovirus
OT  - roseoloviruses
OT  - xenotransplantation
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/06 06:00
MHDA- 2020/10/06 06:00
PMCR- 2019/12/01
CRDT- 2019/12/06 06:00
PHST- 2019/10/31 00:00 [received]
PHST- 2019/11/13 00:00 [revised]
PHST- 2019/11/27 00:00 [accepted]
PHST- 2019/12/06 06:00 [entrez]
PHST- 2019/12/06 06:00 [pubmed]
PHST- 2020/10/06 06:00 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - v11121108 [pii]
AID - viruses-11-01108 [pii]
AID - 10.3390/v11121108 [doi]
PST - epublish
SO  - Viruses. 2019 Nov 30;11(12):1108. doi: 10.3390/v11121108.