PMID- 31801326
OWN - NLM
STAT- MEDLINE
DCOM- 20191223
LR  - 20221207
IS  - 0004-5772 (Print)
IS  - 0004-5772 (Linking)
VI  - 67
IP  - 12
DP  - 2019 Dec
TI  - A Pilot Study Evaluating the Effects of Diabetes Specific Nutrition Supplement 
      and Lifestyle Intervention on Glycemic Control in Overweight and Obese Asian 
      Indian Adults with Type 2 Diabetes Mellitus.
PG  - 25-30
AB  - BACKGROUND AND OBJECTIVES: Medical nutrition therapy plays a crucial role 
      achievement of optimal glycemic control in individuals with diabetes. This study 
      aims to evaluate the effects of diabetes specific nutrition supplement (DSNS) 
      along with lifestyle intervention in overweight and obese adults with Type 2 
      Diabetes Mellitus (T2DM). METHODS: A total of 120 overweight or obese individuals 
      aged 30 - 65 years with T2DM, were randomly allocated to intervention (IG, n=60) 
      and control (CG, n=60) groups in this 12-week study. All participants received 
      dietary counselling with diet chart of 1400 kcal/day and recommendations for 
      physical activity. DSNS was included in the dietary regimen adjusted within the 
      daily calorie recommendations for intervention group. All participants were 
      followed up monthly for anthropometric, biochemical and clinical assessments. 
      Continuous glucose monitoring was performed during the initial 2 weeks and last 2 
      weeks of the study in a sub- sample using Flash Glucose Monitoring device to 
      study glycemic excursions. Data was analyzed for the differences between 
      intervention vs. control group using linear models. RESULTS: Compared to the 
      control group, the intervention group showed significant reduction in 
      glycosylated haemoglobin (IG: -0.95% vs. CG: -0.48%; p=0.020) and fasting blood 
      glucose (IG: -18.47 mg/dL vs. CG: 1.34mg/dL; p=0.03) as well as a greater 
      reduction in postprandial plasma glucose (IG: -29.77mg/dL vs. CG: -2.64mg/dL; 
      p=0.053). There was also a significant reduction from baseline in incremental 
      Area under the Curve (iAUC) (p=0.01) in the intervention group (Delta -22 mg) 
      compared to the control group (Delta -7.9 mg) with a corresponding reduction in the 
      Mean Amplitude of Glycemic Excursion (MAGE) (P=0.04). There was no difference 
      between groups in body weight, waist circumference, blood pressure, and lipid 
      profile. None of the subjects in the study reported serious adverse events. 
      CONCLUSION: This pilot study showed that a diabetes specific nutritional 
      supplement was useful in improving glycemic control and reducing glycemic 
      response in overweight and obese Asian Indian adults with T2DM.
CI  - (c) Journal of the Association of Physicians of India 2011.
FAU - Mohan, Viswanathan
AU  - Mohan V
AD  - Department of Diabetology, Corresponding Author.
FAU - Kalpana, Natarajan
AU  - Kalpana N
AD  - Department of Foods Nutrition and Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, Tamil Nadu.
FAU - Lakshmipriya, Nagarajan
AU  - Lakshmipriya N
AD  - Department of Foods Nutrition and Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, Tamil Nadu.
FAU - Anitha, Purushothaman
AU  - Anitha P
AD  - Department of Foods Nutrition and Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, Tamil Nadu.
FAU - Gayathri, Rajagopal
AU  - Gayathri R
AD  - Department of Foods Nutrition and Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, Tamil Nadu.
FAU - Vijayalakshmi, Parthasarthy
AU  - Vijayalakshmi P
AD  - Department of Foods Nutrition and Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, Tamil Nadu.
FAU - Krishnaswamy, Kamala
AU  - Krishnaswamy K
AD  - Department of Foods Nutrition and Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, Tamil Nadu.
FAU - Unnikrishnan, Ranjit
AU  - Unnikrishnan R
AD  - Department of Diabetology.
FAU - Anjana, Ranjit Mohan
AU  - Anjana RM
AD  - Department of Diabetology.
FAU - Vasudevan, Sudha
AU  - Vasudevan S
AD  - Department of Foods Nutrition and Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, Tamil Nadu.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - India
TA  - J Assoc Physicians India
JT  - The Journal of the Association of Physicians of India
JID - 7505585
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - *Blood Glucose
MH  - Blood Glucose Self-Monitoring
MH  - *Diabetes Mellitus, Type 2
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Life Style
MH  - Middle Aged
MH  - Obesity
MH  - Overweight
MH  - Pilot Projects
EDAT- 2019/12/06 06:00
MHDA- 2019/12/24 06:00
CRDT- 2019/12/06 06:00
PHST- 2019/12/06 06:00 [entrez]
PHST- 2019/12/06 06:00 [pubmed]
PHST- 2019/12/24 06:00 [medline]
PST - ppublish
SO  - J Assoc Physicians India. 2019 Dec;67(12):25-30.