PMID- 31801507
OWN - NLM
STAT- MEDLINE
DCOM- 20200203
LR  - 20200211
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Dec 4
TI  - Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of 
      Ocimum basilicum leaves and its effect on lung pathological changes in an 
      ovalbumin-induced rat model of asthma.
PG  - 349
LID - 10.1186/s12906-019-2765-4 [doi]
LID - 349
AB  - BACKGROUND: Ocimum species (Lamiaceae) has been traditionally used for treatment 
      of upper respiratory tract infections, bronchitis, coughs, sore throat, and wound 
      healing. The Immunomodulatory and anti-inflammatory effects of hydro-ethanolic 
      extract of Ocimum basilicum (O. basilicum) leaves was examined in ovalbumin 
      sensitized animals. METHODS: Wistar rats were divided to six groups; 
      non-sensitized, sensitized to ovalbumin, sensitized and treated with 
      dexamethasone (1.25 mug/mL), and O. basilicum extract (0.75, 1.50 and 3.00 mg/mL) 
      in drinking water for 21 days. The levels of interleukin 4 (IL-4), interferon 
      gamma (IFN-gamma), IFN-gamma/IL-4 ratio, immunoglobulin E (IgE), phospholipase A(2) 
      (PLA(2)) and total protein (TP) in BALF, and lung pathological changes were 
      examined. RESULTS: A significant increase in IL-4, IgE, PLA(2) and TP levels, all 
      lung pathological indices as well as significant decrease in IFN-gamma/IL-4 ratio was 
      seen in the asthmatic compared to the control rats (P < 0.05 to P < 0.001). 
      Treatment with O. basilicum extract resulted in decreased IL-4, IgE, PLA(2) and 
      TP levels, but increased IFN-gamma/IL-4 ratio compared to untreated sensitized rats 
      (P < 0.01 to P < 0.001). The plant significantly improved the pathological 
      changes of sensitized rats (P < 0.05 to P < 0.01). The improvement effects of 
      higher concentrations of the O. basilicum extract were significantly more than 
      those of dexamethasone (P < 0.05 to P < 0.001). CONCLUSION: The improvement 
      effects of O. basilicum on pathological changes, immunological and inflammatory 
      markers in sensitized rats comparable or even more potent than dexamethasone 
      suggests the therapeutic potential of the plant in asthma.
FAU - Eftekhar, Naima
AU  - Eftekhar N
AD  - Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, 
      Mashhad, Iran.
FAU - Moghimi, Ali
AU  - Moghimi A
AD  - Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, 
      Mashhad, Iran.
FAU - Mohammadian Roshan, Nema
AU  - Mohammadian Roshan N
AD  - Department of Pathology, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Saadat, Saeideh
AU  - Saadat S
AD  - Department of Physiology, School of Medicine, Zahedan University of Medical 
      Sciences, Zahedan, Iran.
FAU - Boskabady, Mohammad Hossein
AU  - Boskabady MH
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran. boskabadymh@mums.ac.ir.
AD  - Department of Physiology, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran. boskabadymh@mums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20191204
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - *Asthma/chemically induced/metabolism
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - *Lung/drug effects/pathology
MH  - Male
MH  - *Ocimum basilicum
MH  - Ovalbumin/adverse effects
MH  - Plant Extracts/*pharmacology
MH  - Plant Leaves/chemistry
MH  - Rats
MH  - Rats, Wistar
PMC - PMC6894265
OTO - NOTNLM
OT  - Asthma
OT  - Inflammatory mediators
OT  - Ocimum basilicum, immunological mediators
COIS- The authors declare that they have no competing interests.
EDAT- 2019/12/06 06:00
MHDA- 2020/02/06 06:00
PMCR- 2019/12/04
CRDT- 2019/12/06 06:00
PHST- 2019/05/27 00:00 [received]
PHST- 2019/11/21 00:00 [accepted]
PHST- 2019/12/06 06:00 [entrez]
PHST- 2019/12/06 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/12/04 00:00 [pmc-release]
AID - 10.1186/s12906-019-2765-4 [pii]
AID - 2765 [pii]
AID - 10.1186/s12906-019-2765-4 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2019 Dec 4;19(1):349. doi: 10.1186/s12906-019-2765-4.