PMID- 31801832
OWN - NLM
STAT- MEDLINE
DCOM- 20200319
LR  - 20201229
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 94
IP  - 2
DP  - 2020 Jan 14
TI  - Cerebral microbleed incidence, relationship to amyloid burden: The Mayo Clinic 
      Study of Aging.
PG  - e190-e199
LID - 10.1212/WNL.0000000000008735 [doi]
AB  - OBJECTIVE: To determine the incidence of cerebral microbleeds (CMBs) and the 
      association of amyloid PET burden with incident CMBs. METHODS: A total of 651 
      participants, age >/=50 years (55% male), underwent 3T MRI scans with >/=2 separate 
      T2*-weighted gradient recalled echo sequences from October 2011 to August 2017. 
      Eighty-seven percent underwent (11)C Pittsburgh compound B (PiB) PET scans. 
      Age-specific CMB incidence rates were calculated by using the piecewise 
      exponential model. Using structural equation models (SEMs), we assessed the 
      effect of amyloid load and baseline CMBs on future CMBs after considering the 
      direct and indirect age, sex, vascular risk factors, and APOE effects. RESULTS: 
      Participants' mean age (SD) was 69.8 (10.0) years at baseline MRI, and 111 
      participants (17%) had >/=1 baseline CMB. The mean (SD) of the time interval 
      between scans was 2.7 (1.0) years. The overall population incidence rate for CMBs 
      was 3.6/100 person-years and increased with age: from 1.5/100 new CMBs at age 50 
      to 11.6/100 person-years at age 90. Using the piecewise exponential model 
      regression, the incidence rates increased with age and the presence of baseline 
      CMBs. The SEMs showed that (1) increasing age at MRI or carrying an APOE4 allele 
      was associated with more amyloid at baseline, and higher amyloid, particularly 
      occipital amyloid load, in turn increased the risk of a new lobar CMB; and (2) 
      the presence of CMBs at baseline increased the risk of a lobar CMB and had a 
      larger effect size than amyloid load. CONCLUSIONS: Age and APOE4 carrier status 
      act through amyloid load to increase the risk of subsequent lobar CMBs, but the 
      presence of baseline CMBs is the most important risk factor for future CMBs.
CI  - (c) 2019 American Academy of Neurology.
FAU - Graff-Radford, Jonathan
AU  - Graff-Radford J
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN. 
      Graff-Radford.Jonathan@mayo.edu.
FAU - Lesnick, Timothy
AU  - Lesnick T
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Rabinstein, Alejandro A
AU  - Rabinstein AA
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Gunter, Jeff
AU  - Gunter J
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Aakre, Jeremiah
AU  - Aakre J
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Przybelski, Scott A
AU  - Przybelski SA
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Spychalla, Anthony J
AU  - Spychalla AJ
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Huston, John 3rd
AU  - Huston J 3rd
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Brown, Robert D Jr
AU  - Brown RD Jr
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Mielke, Michelle M
AU  - Mielke MM
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Lowe, Val J
AU  - Lowe VJ
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Knopman, David S
AU  - Knopman DS
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Petersen, Ronald C
AU  - Petersen RC
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Jack, Clifford R Jr
AU  - Jack CR Jr
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Vemuri, Prashanthi
AU  - Vemuri P
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Kremers, Walter
AU  - Kremers W
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
FAU - Kantarci, Kejal
AU  - Kantarci K
AD  - From the Departments of Neurology (J.G.-R., A.A.R., R.D.B., M.M.M., D.S.K., 
      R.C.P.), Health Sciences Research (T.L., J.G., J.A., S.A.P., M.M.M., W.K.), and 
      Radiology (A.J.S., J.H., V.J.L., C.R.J., P.V., K.K.), Mayo Clinic, Rochester, MN.
LA  - eng
GR  - R01 AG041851/AG/NIA NIH HHS/United States
GR  - R01 AG056366/AG/NIA NIH HHS/United States
GR  - R01 AG034676/AG/NIA NIH HHS/United States
GR  - R01 NS097495/NS/NINDS NIH HHS/United States
GR  - R01 AR030582/AR/NIAMS NIH HHS/United States
GR  - U01 AG006786/AG/NIA NIH HHS/United States
GR  - R37 AG011378/AG/NIA NIH HHS/United States
GR  - K76 AG057015/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20191204
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Amyloid)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Amyloid/analysis
MH  - Brain/*pathology
MH  - Cerebral Hemorrhage/*epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Positron-Emission Tomography
PMC - PMC6988987
EDAT- 2019/12/06 06:00
MHDA- 2020/03/20 06:00
PMCR- 2020/01/14
CRDT- 2019/12/06 06:00
PHST- 2019/01/07 00:00 [received]
PHST- 2019/07/05 00:00 [accepted]
PHST- 2019/12/06 06:00 [pubmed]
PHST- 2020/03/20 06:00 [medline]
PHST- 2019/12/06 06:00 [entrez]
PHST- 2020/01/14 00:00 [pmc-release]
AID - WNL.0000000000008735 [pii]
AID - NEUROLOGY2019965053 [pii]
AID - 10.1212/WNL.0000000000008735 [doi]
PST - ppublish
SO  - Neurology. 2020 Jan 14;94(2):e190-e199. doi: 10.1212/WNL.0000000000008735. Epub 
      2019 Dec 4.