PMID- 31801947
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20210110
IS  - 2041-4889 (Electronic)
VI  - 10
IP  - 12
DP  - 2019 Dec 4
TI  - Reciprocal regulation of miR-1205 and E2F1 modulates progression of laryngeal 
      squamous cell carcinoma.
PG  - 916
LID - 10.1038/s41419-019-2154-4 [doi]
LID - 916
AB  - The burgeoning functions of many microRNAs (miRs) have been well study in cancer. 
      However, the level and function of miR-1205 in laryngeal squamous cell cancer 
      remains unknown. In the current research, we validated that miR-1205 was notably 
      downregulated in human laryngeal squamous cell carcinoma (LSCC) samples in 
      comparison with tissues adjacent to LSCC, and correlated with T stage, lymph node 
      metastasis, and clinical stage. Using Kaplan-Meier analysis indicates that high 
      expression of miR-1205 has a favorable prognosis for patients with LSCC. 
      Functional assays show that enforced miR-1205 expression attenuates the 
      migration, growth, and invasion of LSCC cells. And E2F1 is verified to be a 
      target of miR-1205, while E2F1 binds to miR-1205 promoter and transcriptionally 
      inhibits miR-1205 expression. Overexpression of E2F1 reverses the inhibitory 
      impacts of miR-1205 on LSCC cells in part. Importantly, E2F1 is abnormally 
      increased in LSCC tissues, and its protein levels were inversely relevant to 
      miR-1205 expression. High E2F1 protein level is in connection with clinical 
      stage, T stage, lymph node metastasis, and poor prognosis. Consequently, 
      reciprocal regulation of miR-1205 and E2F1 plays a crucial role in the 
      progression of LSCC, suggesting a new miR-1205/E2F1-based clinical application 
      for patients of LSCC.
FAU - Li, Pei
AU  - Li P
AD  - Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
FAU - Lin, Xi-Jun
AU  - Lin XJ
AD  - Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
FAU - Yang, Yang
AU  - Yang Y
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Yang, An-Kui
AU  - Yang AK
AD  - Department of Head and Neck, Sun Yat-sen University Cancer Center; State Key 
      Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer 
      Medicine, Guangzhou, Guangdong, China.
FAU - Di, Jin-Ming
AU  - Di JM
AD  - Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, Guangdong, China.
FAU - Jiang, Qi-Wei
AU  - Jiang QW
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Huang, Jia-Rong
AU  - Huang JR
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Yuan, Meng-Ling
AU  - Yuan ML
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Xing, Zi-Hao
AU  - Xing ZH
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Wei, Meng-Ning
AU  - Wei MN
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Li, Yao
AU  - Li Y
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Yuan, Xiao-Hui
AU  - Yuan XH
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Shi, Zhi
AU  - Shi Z
AUID- ORCID: 0000-0002-8328-0305
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China. tshizhi@jnu.edu.cn.
FAU - Liu, Hui
AU  - Liu H
AD  - Division of Pulmonary and Critical Care, Department of Internal Medicine, The 
      Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. 
      liuhui27@mail.sysu.edu.cn.
FAU - Ye, Jin
AU  - Ye J
AD  - Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. 
      yejin@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191204
PL  - England
TA  - Cell Death Dis
JT  - Cell death & disease
JID - 101524092
RN  - 0 (3' Untranslated Regions)
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Cyclin E)
RN  - 0 (E2F1 Transcription Factor)
RN  - 0 (MIRN1205 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Survivin)
SB  - IM
MH  - 3' Untranslated Regions/genetics
MH  - Animals
MH  - Base Sequence
MH  - Carcinoma, Squamous Cell/*genetics/*pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Cyclin E/metabolism
MH  - *Disease Progression
MH  - Down-Regulation/genetics
MH  - E2F1 Transcription Factor/*genetics/metabolism
MH  - *Gene Expression Regulation, Neoplastic
MH  - HEK293 Cells
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/*pathology
MH  - Lymphatic Metastasis
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - MicroRNAs/*genetics/metabolism
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Survivin/metabolism
MH  - Up-Regulation/genetics
PMC - PMC6893029
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/12/06 06:00
MHDA- 2020/09/01 06:00
PMCR- 2019/12/04
CRDT- 2019/12/06 06:00
PHST- 2019/07/31 00:00 [received]
PHST- 2019/11/07 00:00 [accepted]
PHST- 2019/11/01 00:00 [revised]
PHST- 2019/12/06 06:00 [entrez]
PHST- 2019/12/06 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
PHST- 2019/12/04 00:00 [pmc-release]
AID - 10.1038/s41419-019-2154-4 [pii]
AID - 2154 [pii]
AID - 10.1038/s41419-019-2154-4 [doi]
PST - epublish
SO  - Cell Death Dis. 2019 Dec 4;10(12):916. doi: 10.1038/s41419-019-2154-4.