PMID- 31802554
OWN - NLM
STAT- MEDLINE
DCOM- 20200430
LR  - 20221207
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 34
IP  - 2
DP  - 2020 Feb
TI  - The effect of nettle (Urtica dioica) supplementation on the glycemic control of 
      patients with type 2 diabetes mellitus: A systematic review and meta-analysis.
PG  - 282-294
LID - 10.1002/ptr.6535 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a major health problem, worldwide, that is 
      associated with increased morbidity and mortality. Several randomized controlled 
      clinical trials (RCTs) have investigated the effect of nettle (Urtica dioica) 
      supplementation on markers of glycemic status in patients with T2DM, with 
      conflicting results. Therefore, the present study assessed the effect of nettle 
      on some glycemic parameters in patients with T2DM. A comprehensive search was 
      conducted in PubMed, Scopus, Cochrane Library, and Web of Science, from database 
      inception up to June 2019, to identify RCTs investigating the effect of nettle 
      supplementation on glycemic markers, including fasting blood sugar (FBS) 
      concentrations, insulin levels, homeostasis model assessment-estimated insulin 
      resistance index, and glycosylated hemoglobin percentage in adults with T2DM. The 
      Cochrane Collaboration tool was used to assess the methodological quality of the 
      included studies. Results of this meta-analysis were reported based on the random 
      effects model. Eight RCTs, comprising 401 participants, were included in the 
      present systematic review and meta-analysis. Based on the Cochrane Collaboration 
      risk of bias tool, five studies were considered as good quality, one was fair, 
      and two studies were poor, respectively. The results of the meta-analysis 
      revealed a significant reduction in FBS concentrations (weighted mean difference 
      [WMD]: -18.01 mg/dl, 95% confidence interval [CI]: -30.04 to -5.97, p < .001, 
      I(2) = 94.6%) following nettle supplementation. However, no significant reduction 
      was observed in insulin levels (WMD: 0.83 Hedges' g, 95% CI: -0.26 to 1.92, p = 
      .13, I(2) = 89.4%), homeostasis model assessment-estimated insulin resistance 
      index (WMD: -0.22, 95% CI: -0.83 to 0.40, p = .49, I(2) = 69.2%), or glycosylated 
      hemoglobin percentage (WMD: -0.77%, 95% CI: -1.77 to 0.22, p = .12, I(2) = 
      83.0%). The findings of the present study suggest that nettle supplementation may 
      be effective in controlling FBS for T2DM patients. However, further studies are 
      needed to confirm the veracity of these results.
CI  - (c) 2019 John Wiley & Sons, Ltd.
FAU - Ziaei, Rahele
AU  - Ziaei R
AD  - Department of Community Nutrition, School of Nutrition and Food Science, Food 
      Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Foshati, Sahar
AU  - Foshati S
AD  - Student Research Committee, Department of Clinical Nutrition, School of Nutrition 
      and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Hadi, Amir
AU  - Hadi A
AUID- ORCID: 0000-0001-9952-6579
AD  - Halal Research Center of IRI, FDA, Tehran, Iran.
FAU - Kermani, Mohamad Ail Hojati
AU  - Kermani MAH
AD  - Student Research Committee, Department of Clinical Nutrition, School of Nutrition 
      and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Ghavami, Abed
AU  - Ghavami A
AUID- ORCID: 0000-0001-6817-7812
AD  - Student Research Committee, Department of Clinical Nutrition, School of Nutrition 
      and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Clark, Cain C T
AU  - Clark CCT
AD  - Faculty Research Centre for Sport, Exercise and Life Sciences, Coventry 
      University, Coventry, UK.
FAU - Tarrahi, Mohammad Javad
AU  - Tarrahi MJ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20191204
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Biomarkers/blood
MH  - Blood Glucose/*analysis
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Plant Extracts/*pharmacology
MH  - Randomized Controlled Trials as Topic
MH  - Urtica dioica/*chemistry
OTO - NOTNLM
OT  - glycemic markers
OT  - meta-analysis
OT  - nettle
OT  - systematic review
OT  - type 2 diabetes mellitus
EDAT- 2019/12/06 06:00
MHDA- 2020/05/01 06:00
CRDT- 2019/12/06 06:00
PHST- 2019/05/03 00:00 [received]
PHST- 2019/08/31 00:00 [revised]
PHST- 2019/10/09 00:00 [accepted]
PHST- 2019/12/06 06:00 [pubmed]
PHST- 2020/05/01 06:00 [medline]
PHST- 2019/12/06 06:00 [entrez]
AID - 10.1002/ptr.6535 [doi]
PST - ppublish
SO  - Phytother Res. 2020 Feb;34(2):282-294. doi: 10.1002/ptr.6535. Epub 2019 Dec 4.