PMID- 31803601
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 23
IP  - 5
DP  - 2019 Sep-Oct
TI  - The Clinical Spectrum of Fibrocalculous Pancreatic Diabetes in Kashmir Valley and 
      Comparative Study of the Clinical Profile of Fibrocalculous Pancreatic Diabetes 
      and Type 2 Diabetes Mellitus.
PG  - 580-584
LID - 10.4103/ijem.IJEM_297_19 [doi]
AB  - BACKGROUND: Fibrocalculous pancreatic diabetes (FCPD) is a secondary form of 
      diabetes, described from several tropical countries, including India. We 
      described the existence of this entity in the subtropical region-the Kashmir 
      valley of the Indian subcontinent and compared the clinical characteristics of 
      these patients with type 2 diabetes mellitus (T2DM) patients. AIM: The present 
      study aimed to compare the clinical characteristics of patients with FCPD and 
      those with T2DM to identify the characteristics distinctive of FCPD. MATERIALS 
      AND METHODS: A total of 124 patients with FCPD were compared with 124 patients 
      with T2DM matched for age and duration of diabetes. Biochemical parameters and 
      microvascular and macrovascular complications were assessed in all patients. 
      Multivariate regression analyses were performed to study the determinants of 
      microvascular complications in both groups. RESULTS: FCPD patients had 
      significantly lower serum cholesterol, serum triglyceride, and serum calcium 
      levels but higher glycosylated hemoglobin levels compared to T2DM patients. FCPD 
      participants were significantly leaner. The prevalence of retinopathy, 
      neuropathy, and nephropathy was similar between the two. Five T2DM patients had 
      documented cardiovascular disease compared to one in FCPD patients (P < 0.05). 
      Multiple logistic regression analysis revealed glycosylated hemoglobin and 
      duration of diabetes to be significantly associated with retinopathy and 
      nephropathy in T2DM. Among FCPD patients, glycosylated hemoglobin showed a strong 
      association with retinopathy as well as nephropathy. BMI showed a significant 
      negative association with nephropathy in FCPD patients. Age and age at onset 
      showed a strong association with neuropathy in FCPD patients while the duration 
      of diabetes showed the association with neuropathy (P = 0.015) in T2DM. 
      CONCLUSION: There are several differences in the phenotype, biochemical 
      parameters, and prevalence of diabetic complications between patients with FCPD 
      and T2DM.
CI  - Copyright: (c) 2019 Indian Journal of Endocrinology and Metabolism.
FAU - Bhat, Javaid Ahmad
AU  - Bhat JA
AD  - Department of Endocrinology, Consultant Health, Srinagar, Jammu and Kashmir, 
      India.
FAU - Bhat, Moomin Hussain
AU  - Bhat MH
AD  - Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, 
      Srinagar, Jammu and Kashmir, India.
FAU - Misgar, Raiz Ahmad
AU  - Misgar RA
AD  - Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, 
      Srinagar, Jammu and Kashmir, India.
FAU - Bashir, Mir Iftikhar
AU  - Bashir MI
AD  - Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, 
      Srinagar, Jammu and Kashmir, India.
FAU - Wani, Arshad Iqbal
AU  - Wani AI
AD  - Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, 
      Srinagar, Jammu and Kashmir, India.
FAU - Masoodi, Shariq Rashid
AU  - Masoodi SR
AD  - Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, 
      Srinagar, Jammu and Kashmir, India.
FAU - Ashraf, Hamid
AU  - Ashraf H
AD  - Department of Endocrinology, Rajiv Gandhi Centre for Diabetes and Endocrinology, 
      AMU, Aligarh, Uttar Pradesh, India.
FAU - Sood, Mona
AU  - Sood M
AD  - Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, 
      Srinagar, Jammu and Kashmir, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC6873263
OTO - NOTNLM
OT  - Coronary artery disease
OT  - diabetic nephropathy
OT  - diabetic retinopathy
OT  - fibrocalculous pancreatic diabetes
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest.
EDAT- 2019/12/06 06:00
MHDA- 2019/12/06 06:01
PMCR- 2019/09/01
CRDT- 2019/12/06 06:00
PHST- 2019/12/06 06:00 [entrez]
PHST- 2019/12/06 06:00 [pubmed]
PHST- 2019/12/06 06:01 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - IJEM-23-580 [pii]
AID - 10.4103/ijem.IJEM_297_19 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2019 Sep-Oct;23(5):580-584. doi: 
      10.4103/ijem.IJEM_297_19.