PMID- 31804545
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20220420
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Dec 5
TI  - Dual orexin receptor antagonist induces changes in core body temperature in rats 
      after exercise.
PG  - 18432
LID - 10.1038/s41598-019-54826-3 [doi]
LID - 18432
AB  - Hypothalamic orexin neurons are involved in various physiological functions, 
      including thermoregulation. The orexinergic system has been considered as a 
      potent mediator of the exercise response. The present study describes how the 
      antagonization of the orexinergic system by a dual orexin receptor antagonist 
      (DORA) modifies the thermoregulatory process during exercise. Core Body 
      Temperature (CBT) and Spontaneous Locomotor Activity (SLA) of 12 male Wistar rats 
      were recorded after either oral administration of DORA (30 mg/kg or 60 mg/kg) or 
      placebo solution, both at rest and in exercise conditions with treadmill running. 
      DORA ingestion decreased SLA for 8 hours (p < 0.001) and CBT for 4 hours 
      (p < 0.01). CBT ( degrees C) response was independent of SLA. The CBT level decreased 
      from the beginning to the end of exercise when orexin receptors were antagonized, 
      with a dose-dependent response (39.09 +/- 0.36 and 38.88 +/- 0.28 for 30 and 
      60 mg/kg; p < 0.001) compared to placebo (39.29 +/- 0.31; p < 0.001). CBT increased 
      during exercise was also blunted after DORA administration, but without dose 
      effects of DORA. In conclusion, our results favor the role of orexin in the 
      thermoregulation under stress related to exercise conditions.
FAU - Martin, Tristan
AU  - Martin T
AD  - Normandie Univ, Unicaen, INSERM, COMETE, 14000, Caen, France.
FAU - Dauvilliers, Yves
AU  - Dauvilliers Y
AD  - Reference National Center for Narcolepsy, Sleep Unit, Department of Neurology, 
      Gui-de-Chauliac Hospital, University of Montpellier, Montpellier, INSERM U1061, 
      France.
FAU - Koumar, Ouma-Chandrou
AU  - Koumar OC
AD  - Normandie Univ, Unicaen, INSERM, COMETE, 14000, Caen, France.
FAU - Bouet, Valentine
AU  - Bouet V
AD  - Normandie Univ, Unicaen, INSERM, COMETE, 14000, Caen, France.
FAU - Freret, Thomas
AU  - Freret T
AD  - Normandie Univ, Unicaen, INSERM, COMETE, 14000, Caen, France.
FAU - Besnard, Stephane
AU  - Besnard S
AD  - Normandie Univ, Unicaen, INSERM, COMETE, 14000, Caen, France.
FAU - Dauphin, Francois
AU  - Dauphin F
AD  - Normandie Univ, Unicaen, INSERM, COMETE, 14000, Caen, France.
FAU - Bessot, Nicolas
AU  - Bessot N
AD  - Normandie Univ, Unicaen, INSERM, COMETE, 14000, Caen, France. 
      nicolas.bessot@unicaen.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191205
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Orexin Receptor Antagonists)
RN  - 0 (Orexin Receptors)
SB  - IM
EIN - Sci Rep. 2020 Apr 2;10(1):6030. PMID: 32242040
MH  - Animals
MH  - Body Temperature/*drug effects/physiology
MH  - Body Temperature Regulation/*drug effects/physiology
MH  - Hypothalamus/cytology/drug effects/metabolism
MH  - Locomotion/drug effects/physiology
MH  - Male
MH  - Models, Animal
MH  - Neurons/drug effects/metabolism
MH  - Orexin Receptor Antagonists/*pharmacology
MH  - Orexin Receptors/*metabolism
MH  - Physical Conditioning, Animal
MH  - Rats
PMC - PMC6895233
COIS- The authors declare no competing interests.
EDAT- 2019/12/06 06:00
MHDA- 2020/11/12 06:00
PMCR- 2019/12/05
CRDT- 2019/12/06 06:00
PHST- 2019/05/21 00:00 [received]
PHST- 2019/11/14 00:00 [accepted]
PHST- 2019/12/06 06:00 [entrez]
PHST- 2019/12/06 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2019/12/05 00:00 [pmc-release]
AID - 10.1038/s41598-019-54826-3 [pii]
AID - 54826 [pii]
AID - 10.1038/s41598-019-54826-3 [doi]
PST - epublish
SO  - Sci Rep. 2019 Dec 5;9(1):18432. doi: 10.1038/s41598-019-54826-3.