PMID- 31804625
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 34
IP  - 9
DP  - 2020 Sep
TI  - Choroidal thickness and the retinal ganglion cell complex in chronic Leber's 
      hereditary optic neuropathy: a prospective study using swept-source optical 
      coherence tomography.
PG  - 1624-1630
LID - 10.1038/s41433-019-0695-5 [doi]
AB  - BACKGROUND/OBJECTIVES: Choroidal thinning has been suggested in Leber's 
      hereditary optic neuropathy (LHON). No study has been conducted of the choroid in 
      relation to the retinal ganglion cell-inner plexiform layer (RGC-IPL). We sought 
      to measure choroidal thickness in chronic LHON and to correlate thickness changes 
      with the RGC-IPL. SUBJECTS/METHODS: Chronic LHON, 11778 mitochondrial DNA (mtDNA) 
      mutation, patients (26 eyes; mean age: 35.1 +/- 16.1 years) were prospectively 
      recruited at Doheny Eye Center, University of California Los Angeles from March 
      2016 to July 2017. Age-matched healthy controls (27 eyes; mean age: 32.4 +/- 11.1 
      years) were enroled for comparison. Swept-source optical coherence tomography 
      (SS-OCT) imaging was performed in chronic LHON patients and compared with 
      age-matched healthy controls. RESULTS: The macular choroid was significantly 
      thinner in chronic LHON (250.5 +/- 62.2 mum) compared with controls 
      (313.9 +/- 60.2 mum; p < 0.0001). The peripapillary choroid was also significantly 
      thinner in chronic LHON (135.7 +/- 51.4 mum) compared with controls 
      (183.0 +/- 61.8 mum, p < 0.001). Choroidal thickness strongly correlated with 
      retinal nerve fibre layer (RNFL) thickness in both the macular (R(2) = 0.72; 95% 
      CI, 0.57-0.84) and peripapillary regions (R(2) = 0.53; 95% CI, 0.31-0.70). 
      Choroidal thickness was also significantly correlated with macular RGC-IPL 
      thickness (R(2) = 0.51; 95% CI, 0.26-0.73). CONCLUSIONS: Choroidal thinning in 
      chronic LHON correlated strongly with both RNFL and RGC-IPL thicknesses. These 
      findings may suggest a pathophysiological mechanism involving vascular pathology 
      of the choroid in relation to the retinal ganglion cell complex in LHON.
FAU - Darvizeh, Fatemeh
AU  - Darvizeh F
AD  - Doheny Eye Institute, Los Angeles, CA, USA.
AD  - Department of Ophthalmology, San Raffaele Scientific Institute, Milan, Italy.
FAU - Asanad, Samuel
AU  - Asanad S
AUID- ORCID: 0000-0002-7556-0155
AD  - Doheny Eye Institute, Los Angeles, CA, USA. samuelasanad@gmail.com.
AD  - Department of Ophthalmology, David Geffen School of Medicine, University of 
      California Los Angeles, Los Angeles, CA, USA. samuelasanad@gmail.com.
FAU - Falavarjani, Khalil Ghasemi
AU  - Falavarjani KG
AUID- ORCID: 0000-0001-5221-1844
AD  - Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Wu, Jessica
AU  - Wu J
AD  - Department of Ophthalmology, David Geffen School of Medicine, University of 
      California Los Angeles, Los Angeles, CA, USA.
FAU - Tian, Jack J
AU  - Tian JJ
AUID- ORCID: 0000-0002-5340-7635
AD  - Doheny Eye Institute, Los Angeles, CA, USA.
FAU - Bandello, Francesco
AU  - Bandello F
AD  - Department of Ophthalmology, San Raffaele Scientific Institute, Milan, Italy.
FAU - Ross-Cisneros, Fred N
AU  - Ross-Cisneros FN
AD  - Doheny Eye Institute, Los Angeles, CA, USA.
FAU - Barboni, Piero
AU  - Barboni P
AD  - Department of Ophthalmology, San Raffaele Scientific Institute, Milan, Italy.
FAU - Borrelli, Enrico
AU  - Borrelli E
AUID- ORCID: 0000-0003-2815-5031
AD  - Department of Ophthalmology, San Raffaele Scientific Institute, Milan, Italy.
FAU - Sadun, Alfredo A
AU  - Sadun AA
AD  - Doheny Eye Institute, Los Angeles, CA, USA.
AD  - Department of Ophthalmology, David Geffen School of Medicine, University of 
      California Los Angeles, Los Angeles, CA, USA.
LA  - eng
PT  - Journal Article
DEP - 20191205
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Choroid
MH  - Humans
MH  - Middle Aged
MH  - Nerve Fibers
MH  - *Optic Atrophy, Hereditary, Leber
MH  - Prospective Studies
MH  - *Retinal Ganglion Cells
MH  - Tomography, Optical Coherence
MH  - Young Adult
PMC - PMC7608213
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/12/06 06:00
MHDA- 2021/06/22 06:00
PMCR- 2021/09/01
CRDT- 2019/12/06 06:00
PHST- 2019/03/17 00:00 [received]
PHST- 2019/10/01 00:00 [accepted]
PHST- 2019/09/12 00:00 [revised]
PHST- 2019/12/06 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/12/06 06:00 [entrez]
PHST- 2021/09/01 00:00 [pmc-release]
AID - 10.1038/s41433-019-0695-5 [pii]
AID - 695 [pii]
AID - 10.1038/s41433-019-0695-5 [doi]
PST - ppublish
SO  - Eye (Lond). 2020 Sep;34(9):1624-1630. doi: 10.1038/s41433-019-0695-5. Epub 2019 
      Dec 5.