PMID- 31805225
OWN - NLM
STAT- MEDLINE
DCOM- 20200903
LR  - 20211204
IS  - 1099-0496 (Electronic)
IS  - 8755-6863 (Print)
IS  - 1099-0496 (Linking)
VI  - 55
IP  - 2
DP  - 2020 Feb
TI  - Annual SO(2) exposure, asthma, atopy, and lung function in Puerto Rican children.
PG  - 330-337
LID - 10.1002/ppul.24595 [doi]
AB  - BACKGROUND: Long-term effects of sulfur dioxide (SO(2) ) exposure on children, a 
      vulnerable population, are largely unknown. Further, how long-term SO(2) affects 
      Puerto Rican children living in the island of Puerto Rico, a group with high 
      asthma prevalence, is unclear. We evaluated the effects of annual average 1-hour 
      daily maximum SO(2) average on asthma, atopy, total immunoglobulin E (IgE), and 
      lung function in Puerto Rican children. METHODS: A cohort of 678 children (351 
      with asthma, 327 without asthma) was recruited in Puerto Rico from 2009 to 2010. 
      Annual average 1-hour daily maximum SO(2) exposure was interpolated utilizing 
      publicly available monitoring data. Multivariable logistic and linear regression 
      was used for the analysis of asthma, atopy (defined as an IgE >/=0.35 IU/mL to at 
      least one of five common aero-allergens), total IgE, and lung function measures 
      (forced vital capacity [FVC], forced expiratory volume in 1 second [FEV1], and 
      FEV1/FVC ratio). RESULTS: Annual SO(2) exposure (per 1 ppb) was significantly 
      associated with asthma (odds ratio [OR] = 1.42; 95% confidence interval 
      [CI] = 1.05-1.91) and atopy (OR = 1.35; 95% CI = 1.02-1.78). Such exposure was 
      also significantly associated with lower FEV1/FVC in all children (beta = -1.42; 95% 
      CI = -2.78 to -0.08) and in children with asthma (beta = -2.39; 95% CI= -4.31 to 
      -0.46). Annual SO(2) exposure was not significantly associated with total IgE, 
      FEV1, or FVC. CONCLUSIONS: Among Puerto Rican children in Puerto Rico, long-term 
      SO(2) exposure is linked to asthma and atopy. In these children, long-term SO(2) 
      exposure is also associated with reduced FEV1/FVC, particularly in those with 
      asthma.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Rosser, Franziska
AU  - Rosser F
AUID- ORCID: 0000-0003-1202-044X
AD  - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, 
      University of Pittsburgh, Pittsburgh, Pennsylvania.
FAU - Forno, Erick
AU  - Forno E
AUID- ORCID: 0000-0001-6497-9885
AD  - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, 
      University of Pittsburgh, Pittsburgh, Pennsylvania.
FAU - Kurland, Kristen S
AU  - Kurland KS
AD  - H John Heinz III College and School of Architecture, Carnegie Mellon University, 
      Pittsburgh, Pennsylvania.
FAU - Han, Yueh-Ying
AU  - Han YY
AUID- ORCID: 0000-0002-8409-3077
AD  - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, 
      University of Pittsburgh, Pittsburgh, Pennsylvania.
FAU - Mair, Christina
AU  - Mair C
AUID- ORCID: 0000-0003-3841-3313
AD  - Department of Behavioral and Community Health Sciences, University of Pittsburgh 
      Graduate School of Public Health, Pittsburgh, Pennsylvania.
FAU - Acosta-Perez, Edna
AU  - Acosta-Perez E
AUID- ORCID: 0000-0001-7101-3157
AD  - Behavioral Sciences Research Institute of Puerto Rico, University of Puerto Rico, 
      San Juan, Puerto Rico.
FAU - Canino, Glorisa
AU  - Canino G
AD  - Behavioral Sciences Research Institute of Puerto Rico, University of Puerto Rico, 
      San Juan, Puerto Rico.
FAU - Celedon, Juan C
AU  - Celedon JC
AUID- ORCID: 0000-0002-6139-5320
AD  - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, 
      University of Pittsburgh, Pittsburgh, Pennsylvania.
LA  - eng
GR  - HL079966/NH/NIH HHS/United States
GR  - MD011764/NH/NIH HHS/United States
GR  - HL117191/NH/NIH HHS/United States
GR  - R01 MD011764/MD/NIMHD NIH HHS/United States
GR  - R01 HL079966/HL/NHLBI NIH HHS/United States
GR  - KL2TR001856/NH/NIH HHS/United States
GR  - KL2 TR001856/TR/NCATS NIH HHS/United States
GR  - R01 HL117191/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20191205
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
RN  - 0 (Allergens)
RN  - 0UZA3422Q4 (Sulfur Dioxide)
SB  - IM
MH  - Adolescent
MH  - Air Pollution/*statistics & numerical data
MH  - Allergens
MH  - Asthma/*epidemiology/physiopathology
MH  - Child
MH  - Cohort Studies
MH  - Female
MH  - Hispanic or Latino
MH  - Humans
MH  - Hypersensitivity, Immediate
MH  - Inhalation Exposure/*statistics & numerical data
MH  - Lung/physiopathology
MH  - Male
MH  - Odds Ratio
MH  - Prevalence
MH  - Puerto Rico/epidemiology
MH  - Respiratory Function Tests
MH  - Sulfur Dioxide/*analysis
MH  - Vital Capacity
PMC - PMC7122992
MID - NIHMS1570290
OTO - NOTNLM
OT  - Puerto Rican children
OT  - SO2 exposure
OT  - air pollution
OT  - asthma
OT  - atopy
OT  - lung function
COIS- Disclosures of interest: Dr. Celedon has received research materials from GSK and 
      Merck (inhaled steroids) and Pharmavite (vitamin D and placebo capsules), in 
      order to provide medications free of cost to participants in NIH-funded studies, 
      unrelated to the current work. The other authors declare no conflicts of 
      interest.
EDAT- 2019/12/06 06:00
MHDA- 2020/09/04 06:00
PMCR- 2021/02/01
CRDT- 2019/12/06 06:00
PHST- 2019/08/27 00:00 [received]
PHST- 2019/11/20 00:00 [accepted]
PHST- 2019/12/06 06:00 [pubmed]
PHST- 2020/09/04 06:00 [medline]
PHST- 2019/12/06 06:00 [entrez]
PHST- 2021/02/01 00:00 [pmc-release]
AID - 10.1002/ppul.24595 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2020 Feb;55(2):330-337. doi: 10.1002/ppul.24595. Epub 2019 Dec 
      5.