PMID- 31805637
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2076-0817 (Print)
IS  - 2076-0817 (Electronic)
IS  - 2076-0817 (Linking)
VI  - 8
IP  - 4
DP  - 2019 Dec 1
TI  - The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia 
      trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among 
      Young Women in Finland.
LID - 10.3390/pathogens8040276 [doi]
LID - 276
AB  - Chlamydia trachomatis, Mycoplasma genitalium, herpes simplex virus (HSV) and 
      human papillomavirus (HPV) cause sexually transmitted infections. In addition, 
      human herpesvirus 6 (HHV-6) may be a genital co-pathogen. The prevalence rates of 
      HSV, HHV-6, HPV, M. genitalium, and the C. trachomatis ompA genotypes were 
      investigated by PCR in urogenital samples of the C. trachomatis nucleic acid 
      amplification test positive (n = 157) and age-, community- and time-matched 
      negative (n = 157) women. The prevalence of HPV DNA was significantly higher 
      among the C. trachomatis positives than the C. trachomatis negatives (66% vs. 
      25%, p < 0.001). The prevalence of HSV (1.9% vs. 0%), HHV-6 (11% vs. 14%), and M. 
      genitalium DNA (4.5% vs. 1.9%) was not significantly different between the C. 
      trachomatis-positive and -negative women. Thirteen per cent of test-of-cure 
      specimens tested positive for C. trachomatis. The prevalence of HSV, HHV-6, HPV, 
      M. genitalium, and the C. trachomatis ompA genotypes did not significantly differ 
      between those who cleared the C. trachomatis infection (n = 105) and those who 
      did not (n = 16). The higher prevalence of HPV DNA among the C. trachomatis 
      positives suggests greater sexual activity and increased risk for sexually 
      transmitted pathogens.
FAU - Korhonen, Suvi
AU  - Korhonen S
AD  - Department of Virology, University of Helsinki and Helsinki University Hospital, 
      PO Box 21, FI-00014 Helsinki, Finland.
FAU - Hokynar, Kati
AU  - Hokynar K
AD  - Department of Virology, University of Helsinki and Helsinki University Hospital, 
      PO Box 21, FI-00014 Helsinki, Finland.
FAU - Eriksson, Tiina
AU  - Eriksson T
AD  - Faculty of Social Sciences, Tampere University, PO Box 100, FI-33014 ‎Tampere, 
      Finland.
FAU - Natunen, Kari
AU  - Natunen K
AD  - Faculty of Social Sciences, Tampere University, PO Box 100, FI-33014 ‎Tampere, 
      Finland.
FAU - Paavonen, Jorma
AU  - Paavonen J
AD  - Obstetrics and Gynecology, University of Helsinki and Helsinki University 
      Hospital, PO Box 140, FI-00029 HUS Helsinki, Finland.
FAU - Lehtinen, Matti
AU  - Lehtinen M
AD  - Faculty of Social Sciences, Tampere University, PO Box 100, FI-33014 ‎Tampere, 
      Finland.
AD  - Department of Laboratory Medicine, Karolinska Institute, Alfred Nobels Alle 8, 
      14183 Stockholm, Sweden.
FAU - Puolakkainen, Mirja
AU  - Puolakkainen M
AD  - Department of Virology, University of Helsinki and Helsinki University Hospital, 
      PO Box 21, FI-00014 Helsinki, Finland.
LA  - eng
GR  - 1285975/Academy of Finland/
GR  - TYH2013405/MP; TYH2014117/MP; TYH2015318/MP/Helsingin ja Uudenmaan 
      Sairaanhoitopiiri/
GR  - 2011; 2014/Finnish Society against STIs/
PT  - Journal Article
DEP - 20191201
PL  - Switzerland
TA  - Pathogens
JT  - Pathogens (Basel, Switzerland)
JID - 101596317
PMC - PMC6963806
OTO - NOTNLM
OT  - chlamydial co-infection
OT  - sexually transmitted infection
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2019/12/07 06:00
MHDA- 2019/12/07 06:01
PMCR- 2019/12/01
CRDT- 2019/12/07 06:00
PHST- 2019/10/30 00:00 [received]
PHST- 2019/11/28 00:00 [revised]
PHST- 2019/11/29 00:00 [accepted]
PHST- 2019/12/07 06:00 [entrez]
PHST- 2019/12/07 06:00 [pubmed]
PHST- 2019/12/07 06:01 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - pathogens8040276 [pii]
AID - pathogens-08-00276 [pii]
AID - 10.3390/pathogens8040276 [doi]
PST - epublish
SO  - Pathogens. 2019 Dec 1;8(4):276. doi: 10.3390/pathogens8040276.