PMID- 31805776
OWN - NLM
STAT- MEDLINE
DCOM- 20201013
LR  - 20201013
IS  - 1477-2213 (Electronic)
IS  - 1028-6020 (Linking)
VI  - 22
IP  - 11
DP  - 2020 Nov
TI  - Ameliorative effect of acetylshikonin on cigarette smoke-induced lung 
      inflammation in mice.
PG  - 1078-1094
LID - 10.1080/10286020.2019.1694512 [doi]
AB  - Cigarette smoke exposure is the major cause of chronic obstructive pulmonary 
      disease (COPD). Acetylshikonin was the active principle component of Purple 
      Gromwell that show anti-oxidative and anti-inflammatory effect. However, no data 
      are available to elucidate the protective effect of acetylshikonin on COPD. 
      Acetylshikonin could attenuate smoke-induced lung pathological changes, tumor 
      necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and 
      monocyte chemoattractant protein 1 (MCP-1) productions, and tissue damages caused 
      by oxidative stress. Furthermore, acetylshikonin was found to enhance the 
      expression of Nrf2 and Nur77-mediated COX-2 in vivo and in vitro.
FAU - Zhang, Xiao-Yan
AU  - Zhang XY
AD  - Department of Pulmonary and Critical Care Medicine, China-Japan Friendship 
      Hospital, Beijing 100029, China.
AD  - National Clinical Research Center for Respiratory Diseases, Beijing 100029, 
      China.
AD  - Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing 
      100029, China.
FAU - Jia, Yu-Ping
AU  - Jia YP
AD  - Department of Pulmonary and Critical Care Medicine, China-Japan Friendship 
      Hospital, Beijing 100029, China.
AD  - National Clinical Research Center for Respiratory Diseases, Beijing 100029, 
      China.
AD  - Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing 
      100029, China.
FAU - Zhao, Qing
AU  - Zhao Q
AD  - Department of Pulmonary and Critical Care Medicine, China-Japan Friendship 
      Hospital, Beijing 100029, China.
AD  - National Clinical Research Center for Respiratory Diseases, Beijing 100029, 
      China.
AD  - Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing 
      100029, China.
FAU - Wang, Wen-Ya
AU  - Wang WY
AD  - Department of Pulmonary and Critical Care Medicine, China-Japan Friendship 
      Hospital, Beijing 100029, China.
AD  - National Clinical Research Center for Respiratory Diseases, Beijing 100029, 
      China.
AD  - Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing 
      100029, China.
FAU - Zhang, Zhi
AU  - Zhang Z
AD  - Department of Emergency, China-Japan Friendship Hospital, Beijing 100029, China.
FAU - Li, Wen
AU  - Li W
AD  - Department of Emergency, China-Japan Friendship Hospital, Beijing 100029, China.
FAU - Sun, Li-Chao
AU  - Sun LC
AD  - Department of Emergency, China-Japan Friendship Hospital, Beijing 100029, China.
LA  - eng
PT  - Journal Article
DEP - 20191205
PL  - England
TA  - J Asian Nat Prod Res
JT  - Journal of Asian natural products research
JID - 100888334
RN  - 0 (Anthraquinones)
RN  - 0 (Smoke)
RN  - ST04094S3X (acetylshikonin)
SB  - IM
MH  - Animals
MH  - Anthraquinones
MH  - Inflammation/chemically induced/drug therapy
MH  - Mice
MH  - Molecular Structure
MH  - *Pneumonia
MH  - *Smoke/adverse effects
MH  - Smoking/adverse effects
OTO - NOTNLM
OT  - Acetylshikonin
OT  - COPD
OT  - inflammation
OT  - oxidative stress
OT  - smoke inhalation
EDAT- 2019/12/07 06:00
MHDA- 2020/10/21 06:00
CRDT- 2019/12/07 06:00
PHST- 2019/12/07 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/12/07 06:00 [entrez]
AID - 10.1080/10286020.2019.1694512 [doi]
PST - ppublish
SO  - J Asian Nat Prod Res. 2020 Nov;22(11):1078-1094. doi: 
      10.1080/10286020.2019.1694512. Epub 2019 Dec 5.