PMID- 31805945
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20200518
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 18
IP  - 1
DP  - 2019 Dec 5
TI  - Association of glycemic variability with left ventricular diastolic function in 
      type 2 diabetes mellitus.
PG  - 166
LID - 10.1186/s12933-019-0971-5 [doi]
LID - 166
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major cause of heart failure 
      (HF) with preserved ejection fraction (HFpEF), usually presenting as left 
      ventricular (LV) diastolic dysfunction. Thus, LV diastolic function should be 
      considered a crucial marker of a preclinical form of DM-related cardiac 
      dysfunction. However, the impact of glycemic variability (GV) on LV diastolic 
      function in such patients remains unclear. METHODS: We studied 100 asymptomatic 
      T2DM patients with preserved LV ejection fraction (LVEF) without coronary artery 
      disease (age: 60 +/- 14 years, female: 45%). GV was evaluated as standard deviation 
      of blood glucose level using continuous glucose monitoring system for at least 72 
      consecutive hours. LV diastolic function was defined as mitral inflow E and 
      mitral e' annular velocities (E/e'), and > 14 was determined as abnormal. 
      RESULTS: E/e' in patients with high GV (>/= 35.9 mg/dL) was significantly higher 
      than that in patients with low GV (11.3 +/- 3.9 vs. 9.8 +/- 2.8, p = 0.03) despite 
      similar age, gender-distribution, and hemoglobin A1c (HbA1c). Multivariate 
      logistic regression analysis showed that GV >/= 35.9 mg/dL (odds ratio: 3.67; 95% 
      confidence interval: 1.02-13.22; p < 0.05) was an independently associated 
      factor, as was age, of E/e' > 14. In sequential logistic models for the 
      associations of LV diastolic dysfunction, one model based on clinical variables 
      including age, gender and hypertension was not improved by addition of HbA1c 
      (p = 0.67) but was improved by addition of high GV (p = 0.04). CONCLUSION: Since 
      HFpEF is a syndrome caused by diverse agents, reducing GV may represent a 
      potential new therapeutic strategy for the prevention of the development of HFpEF 
      in T2DM patients.
FAU - Yokota, Shun
AU  - Yokota S
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Tanaka, Hidekazu
AU  - Tanaka H
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan. tanakah@med.kobe-u.ac.jp.
FAU - Mochizuki, Yasuhide
AU  - Mochizuki Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Soga, Fumitaka
AU  - Soga F
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Yamashita, Kentaro
AU  - Yamashita K
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Tanaka, Yusuke
AU  - Tanaka Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Shono, Ayu
AU  - Shono A
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Suzuki, Makiko
AU  - Suzuki M
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Sumimoto, Keiko
AU  - Sumimoto K
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Mukai, Jun
AU  - Mukai J
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Suto, Makiko
AU  - Suto M
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Takada, Hiroki
AU  - Takada H
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Matsumoto, Kensuke
AU  - Matsumoto K
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Hirota, Yushi
AU  - Hirota Y
AD  - Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Ogawa, Wataru
AU  - Ogawa W
AD  - Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Hirata, Ken-Ichi
AU  - Hirata KI
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
LA  - eng
PT  - Journal Article
DEP - 20191205
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/blood/*complications/diagnosis
MH  - Diabetic Cardiomyopathies/diagnostic imaging/*etiology/physiopathology
MH  - Diastole
MH  - Female
MH  - Heart Failure/diagnostic imaging/*etiology/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Stroke Volume
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*etiology/physiopathology
MH  - *Ventricular Function, Left
PMC - PMC6894492
OTO - NOTNLM
OT  - Diastolic function
OT  - Echocardiography
OT  - Glycemic variability
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2019/12/07 06:00
MHDA- 2020/05/19 06:00
PMCR- 2019/12/05
CRDT- 2019/12/07 06:00
PHST- 2019/10/23 00:00 [received]
PHST- 2019/11/23 00:00 [accepted]
PHST- 2019/12/07 06:00 [entrez]
PHST- 2019/12/07 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2019/12/05 00:00 [pmc-release]
AID - 10.1186/s12933-019-0971-5 [pii]
AID - 971 [pii]
AID - 10.1186/s12933-019-0971-5 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2019 Dec 5;18(1):166. doi: 10.1186/s12933-019-0971-5.