PMID- 31807420
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2223-4691 (Print)
IS  - 2223-4691 (Electronic)
IS  - 2223-4683 (Linking)
VI  - 8
IP  - 5
DP  - 2019 Oct
TI  - The value of cystatin C and urinary and serum neutrophil gelatinase-associated 
      lipocalin during the perioperative period of renal transplantation.
PG  - 432-441
LID - 10.21037/tau.2019.08.12 [doi]
AB  - BACKGROUND: The perioperative management of renal transplantation is complex. Our 
      research aimed to study the clinical value of cystatin-C (Cys-C) and urinary and 
      serum neutrophil gelatinase-associated lipocalin (NGAL) during the perioperative 
      period of renal transplantation. METHODS: We collected the clinical information 
      of 47 renal transplantation patients. Urine and serum samples were collected 
      daily until the second week and then weekly until discharge to determine serum 
      NGAL (s-NGAL), urine NGAL (u-NGAL), serum creatinine (s-Cr), and Cys-C levels. 
      Receiver-operating characteristic (ROC) analysis was used, and the area under the 
      curve (AUC) was compared to evaluate the accuracy of the diagnosis of delayed 
      graft function (DGF). Multivariable analysis was used to find the association 
      between the markers and renal function at discharge. RESULTS: In our research, 
      the value of Cys-C, serum NGAL, and urine NGAL were higher in DGF group. In the 
      ROC analysis, Cys-C had the highest AUC (0.939) compared with s-NGAL (0.909), 
      u-NGAL (0.856), and s-Cr (0.747). Multivariable analysis showed that Cys-C levels 
      in the first week after the operation and cold ischemia time were independently 
      associated with estimated glomerular filtration rate (eGFR) at discharge 
      (P<0.05). CONCLUSIONS: Our results showed that Cys-C, serum NGAL, and urine NGAL 
      could reflect renal function sensitively. Cys-C had the highest sum of 
      sensitivity and specificity at 4.77 mg/L, with a sensitivity of 0.818 and 
      specificity of 0.889. The Cys-C level during the first week after the operation 
      was independently associated with eGFR at discharge and could predict the 
      short-term prognosis of renal transplantation patients.
CI  - 2019 Translational Andrology and Urology. All rights reserved.
FAU - Li, Feng
AU  - Li F
AD  - Department of Urinary Surgery, The First Affiliated Hospital, Soochow University, 
      Suzhou 215006, China.
FAU - Hu, Linkun
AU  - Hu L
AD  - Department of Urinary Surgery, The First Affiliated Hospital, Soochow University, 
      Suzhou 215006, China.
FAU - Zhao, Xiaojun
AU  - Zhao X
AD  - Department of Urinary Surgery, The First Affiliated Hospital, Soochow University, 
      Suzhou 215006, China.
FAU - Ge, Wenqing
AU  - Ge W
AD  - Department of Urinary Surgery, The First Affiliated Hospital, Soochow University, 
      Suzhou 215006, China.
FAU - Pan, Hao
AU  - Pan H
AD  - Department of Urinary Surgery, The First Affiliated Hospital, Soochow University, 
      Suzhou 215006, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Urinary Surgery, The First Affiliated Hospital, Soochow University, 
      Suzhou 215006, China.
FAU - Jiang, Yufeng
AU  - Jiang Y
AD  - Department of Urinary Surgery, The First Affiliated Hospital, Soochow University, 
      Suzhou 215006, China.
FAU - Xu, Xu
AU  - Xu X
AD  - Department of Urinary Surgery, The First Affiliated Hospital, Soochow University, 
      Suzhou 215006, China.
FAU - Hou, Jianquan
AU  - Hou J
AD  - Department of Urinary Surgery, The First Affiliated Hospital, Soochow University, 
      Suzhou 215006, China.
FAU - Pu, Jinxian
AU  - Pu J
AD  - Department of Urinary Surgery, The First Affiliated Hospital, Soochow University, 
      Suzhou 215006, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Transl Androl Urol
JT  - Translational andrology and urology
JID - 101581119
PMC - PMC6842783
OTO - NOTNLM
OT  - Renal transplantation
OT  - cystatin-C (Cys-C)
OT  - delayed graft function (DGF)
OT  - neutrophil gelatinase-associated lipocalin (NGAL)
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2019/12/07 06:00
MHDA- 2019/12/07 06:01
PMCR- 2019/10/01
CRDT- 2019/12/07 06:00
PHST- 2019/12/07 06:00 [entrez]
PHST- 2019/12/07 06:00 [pubmed]
PHST- 2019/12/07 06:01 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - tau-08-05-432 [pii]
AID - 10.21037/tau.2019.08.12 [doi]
PST - ppublish
SO  - Transl Androl Urol. 2019 Oct;8(5):432-441. doi: 10.21037/tau.2019.08.12.