PMID- 31808446
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2048-8505 (Print)
IS  - 2048-8513 (Electronic)
IS  - 2048-8505 (Linking)
VI  - 12
IP  - 6
DP  - 2019 Dec
TI  - Trends of renal diseases in Germany: review of a regional renal biopsy database 
      from 1990 to 2013.
PG  - 795-800
LID - 10.1093/ckj/sfz023 [doi]
AB  - BACKGROUND: Several renal biopsy registries in Europe have shown geographical and 
      temporal variations in the patterns of renal diseases. However, there is a lack 
      of current data on trends of renal disease in Central Europe. METHODS: After 
      exclusion of transplant and re-biopsies, the renal biopsy registry of the German 
      RWTH Aachen University Hospital included data of 1208 biopsies over a period of 
      24 years (1990-2013). Trends in the biopsy rate and diagnosis of glomerular 
      diseases were analysed. RESULTS: The average annual biopsy incidence was 6.1 
      biopsies per 100 000 population. The frequency of kidney biopsies increased 
      significantly over the years (P < 0.001). Primary glomerulonephritis (GN) 
      accounted for nearly two-thirds (58.4%) of all native kidney biopsies, and 
      immunoglobulin A-nephropathy (IgAN) was the leading histological diagnosis 
      (34.7%) followed by necrotizing GN (RPGN) at 18.7%. IgAN increased 2-fold over 
      the study periods (+195%, P < 0.001). Focal segmental glomerulosclerosis 
      accounted for 6.1% of all diagnoses, and its frequency rose to 3.9-fold (+388%, 
      P < 0.001). Lupus nephritis showed a doubling in incidence (P = 0.0499), while 
      acute tubular necrosis decreased to 3.5-fold (P = 0.0008). All other disease 
      entities failed to exhibit linear trends over time. In children, the most common 
      pathologies were IgAN (26.1%) and minimal change disease (21.7%), whereas RPGN 
      (19.4%) dominated in the group of patients >60 years. CONCLUSION: IgAN was the 
      most common primary glomerular disease in our centre and its prevalence increased 
      over 24 years.
CI  - (c) The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.
FAU - Zink, Corinna M
AU  - Zink CM
AD  - Department of Nephrology and Clinical Immunology, RWTH Aachen University 
      Hospital, Aachen, Germany.
FAU - Ernst, Sabine
AU  - Ernst S
AD  - Department of Nephrology and Clinical Immunology, RWTH Aachen University 
      Hospital, Aachen, Germany.
FAU - Riehl, Jochen
AU  - Riehl J
AD  - Department of Nephrology and Clinical Immunology, RWTH Aachen University 
      Hospital, Aachen, Germany.
FAU - Helmchen, Udo
AU  - Helmchen U
AD  - Institute of Pathology, Kidney Registry, University Hospital Hamburg-Eppendorf, 
      Hamburg, Germany.
FAU - Grone, Hermann-Josef
AU  - Grone HJ
AD  - Department of Cellular and Molecular Pathology, German Cancer Research Center 
      (DKFZ), Heidelberg, Germany.
FAU - Floege, Jurgen
AU  - Floege J
AD  - Department of Nephrology and Clinical Immunology, RWTH Aachen University 
      Hospital, Aachen, Germany.
FAU - Schlieper, Georg
AU  - Schlieper G
AUID- ORCID: 0000-0001-6050-5842
AD  - Department of Nephrology and Clinical Immunology, RWTH Aachen University 
      Hospital, Aachen, Germany.
AD  - Center for Nephrology, Hypertension, and Metabolic Diseases, Hannover, Germany.
LA  - eng
PT  - Journal Article
DEP - 20190318
PL  - England
TA  - Clin Kidney J
JT  - Clinical kidney journal
JID - 101579321
EIN - Clin Kidney J. 2019 Nov 12;14(1):462. PMID: 33564460
PMC - PMC6885677
OTO - NOTNLM
OT  - CKD
OT  - FSGS
OT  - IgA nephropathy
OT  - glomerulonephritis
OT  - kidney biopsy
EDAT- 2019/12/07 06:00
MHDA- 2019/12/07 06:01
PMCR- 2019/03/18
CRDT- 2019/12/07 06:00
PHST- 2018/12/07 00:00 [received]
PHST- 2019/12/07 06:00 [entrez]
PHST- 2019/12/07 06:00 [pubmed]
PHST- 2019/12/07 06:01 [medline]
PHST- 2019/03/18 00:00 [pmc-release]
AID - sfz023 [pii]
AID - 10.1093/ckj/sfz023 [doi]
PST - epublish
SO  - Clin Kidney J. 2019 Mar 18;12(6):795-800. doi: 10.1093/ckj/sfz023. eCollection 
      2019 Dec.