PMID- 31808602 OWN - NLM STAT- MEDLINE DCOM- 20201127 LR - 20210110 IS - 1557-0657 (Electronic) IS - 1049-8931 (Print) IS - 1049-8931 (Linking) VI - 29 IP - 1 DP - 2020 Mar TI - The Alcohol Dependence Scale and DSM-5 alcohol use disorder: Severity ratings correspond insufficiently in older patients. PG - e1811 LID - 10.1002/mpr.1811 [doi] LID - e1811 AB - OBJECTIVES: To investigate the psychometric properties of the frequently used Alcohol Dependence Scale (ADS) in older adults and the associations between ADS scores and alcohol use and DSM-5 AUD symptom counts. METHODS: Using baseline data from an international multicenter RCT on outpatient AUD treatment for adults aged 60+ with DSM-5 alcohol use disorder (AUD; n = 529), we computed Cronbach's alpha (alpha) and applied confirmatory (CFA) and exploratory factor analysis (EFA) to determine the underlying factor structure. A structural equation model (SEM) explored the interrelationship of latent ADS factors with alcohol use and number of DSM-5 criteria endorsed. RESULTS: Internal consistency of the ADS (alpha = 0.81) was good. EFA revealed a three-factor structure. Factor 1 ("Severe withdrawal symptoms") consisted of severe psychoperceptual and psychophysical consequences of excessive drinking, Factor 2 ("Loss of control") consisted of acute physical reactions of intoxication, and Factor 3 ("Obsessive-compulsive drinking") described habitual drinking. The SEM suggested that only Factor 3 had large effects on DSM-5 symptom score and drinking behavior. CONCLUSION: Lowering the ADS threshold or focusing on ADS items from Factor 3 may be more suitable measures of severity of alcohol dependence in treatment-seeking older adults as ADS scores are low and not closely related to DSM-5 AUD. CI - (c) 2019 The Authors. International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd. FAU - Mejldal, Anna AU - Mejldal A AUID- ORCID: 0000-0002-4612-4338 AD - Unit of Clinical Alcohol Research, Institute of Clinical Research, University of Southern DenmarkOdense, Denmark. AD - OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark. AD - Psychiatric Department, Region of Southern Denmark, Odense, Denmark. FAU - Andersen, Kjeld AU - Andersen K AD - Unit of Clinical Alcohol Research, Institute of Clinical Research, University of Southern DenmarkOdense, Denmark. AD - OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark. AD - BRIDGE, Brain Research, Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. AD - Psychiatric Department, Region of Southern Denmark, Odense, Denmark. FAU - Bilberg, Randi AU - Bilberg R AD - Unit of Clinical Alcohol Research, Institute of Clinical Research, University of Southern DenmarkOdense, Denmark. AD - OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark. AD - Psychiatric Department, Region of Southern Denmark, Odense, Denmark. FAU - Braun, Barbara AU - Braun B AD - IFT, Institut fur Therapieforschung, Munich, Germany. FAU - Bogenschutz, Michael AU - Bogenschutz M AD - Bellevue Hospital Center, New York, USA. FAU - Buhringer, Gerhard AU - Buhringer G AD - Unit of Clinical Alcohol Research, Institute of Clinical Research, University of Southern DenmarkOdense, Denmark. AD - IFT, Institut fur Therapieforschung, Munich, Germany. AD - Institute of Clinical Psychology and PsychotherapyTechnische Universitat Dresden, Dresden, Germany. FAU - Nielsen, Anette Sogaard AU - Nielsen AS AD - Unit of Clinical Alcohol Research, Institute of Clinical Research, University of Southern DenmarkOdense, Denmark. AD - OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark. AD - BRIDGE, Brain Research, Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. AD - Psychiatric Department, Region of Southern Denmark, Odense, Denmark. FAU - Silke, Behrendt AU - Silke B AD - Unit of Clinical Alcohol Research, Institute of Clinical Research, University of Southern DenmarkOdense, Denmark. AD - BRIDGE, Brain Research, Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. AD - Psychiatric Department, Region of Southern Denmark, Odense, Denmark. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191205 PL - United States TA - Int J Methods Psychiatr Res JT - International journal of methods in psychiatric research JID - 9111433 SB - IM MH - Aged MH - Aged, 80 and over MH - Aging/*physiology MH - Alcoholism/*diagnosis/*physiopathology MH - Diagnostic and Statistical Manual of Mental Disorders MH - Factor Analysis, Statistical MH - Female MH - Humans MH - Male MH - Middle Aged MH - Multicenter Studies as Topic MH - Psychiatric Status Rating Scales/*standards MH - Psychometrics/*standards MH - Randomized Controlled Trials as Topic MH - *Severity of Illness Index PMC - PMC7051836 OTO - NOTNLM OT - alcohol dependence OT - assessment OT - diagnosis OT - older adults OT - severity EDAT- 2019/12/07 06:00 MHDA- 2020/11/28 06:00 PMCR- 2019/12/05 CRDT- 2019/12/07 06:00 PHST- 2019/06/09 00:00 [received] PHST- 2019/09/10 00:00 [revised] PHST- 2019/10/08 00:00 [accepted] PHST- 2019/12/07 06:00 [pubmed] PHST- 2020/11/28 06:00 [medline] PHST- 2019/12/07 06:00 [entrez] PHST- 2019/12/05 00:00 [pmc-release] AID - MPR1811 [pii] AID - 10.1002/mpr.1811 [doi] PST - ppublish SO - Int J Methods Psychiatr Res. 2020 Mar;29(1):e1811. doi: 10.1002/mpr.1811. Epub 2019 Dec 5.