PMID- 31809019
OWN - NLM
STAT- MEDLINE
DCOM- 20210204
LR  - 20210204
IS  - 1520-4812 (Electronic)
IS  - 1043-1802 (Linking)
VI  - 31
IP  - 1
DP  - 2020 Jan 15
TI  - Acridine Orange Encapsulated Mesoporous Manganese Dioxide Nanoparticles to 
      Enhance Radiotherapy.
PG  - 82-92
LID - 10.1021/acs.bioconjchem.9b00751 [doi]
AB  - Manganese dioxide (MnO(2)) nanoparticles are a promising type of radiosensitizer 
      for they can catalyze H(2)O(2) decomposition to produce O(2). Combining MnO(2) 
      nanoparticles with conventional, small molecule radiosensitizers would further 
      enhance radiotherapy (RT) efficacy due to complementary mechanisms of action. 
      However, solid MnO(2) nanoparticles are suboptimal at drug loading, limiting the 
      related progress. Herein we report a facile method to synthesize mesoporous 
      MnO(2) (mMnO(2)) nanoparticles, which can efficiently encapsulate small molecule 
      therapeutics. In particular, we found that acridine orange (AO), a small molecule 
      radiosensitizer, can be loaded onto mMnO(2) nanoparticles at very high efficiency 
      and released to the surroundings in a controlled fashion. We show that mMnO(2) 
      nanoparticles can efficiently produce O(2) inside cells. This, together with 
      AO-induced DNA damage, significantly enhances RT outcomes, which was validated 
      both in vitro and in vivo. Meanwhile, mMnO(2) nanoparticles slowly degrade in 
      acidic environments to release Mn(2+), providing a facile way to keep track of 
      the nanoparticles through magnetic resonance imaging (MRI). Overall, our studies 
      suggest mMnO(2) as a promising nanoplatform that can be exploited to produce 
      composite radiosensitizers for RT.
FAU - Liu, Junzhi
AU  - Liu J
FAU - Zhang, Weizhong
AU  - Zhang W
AD  - Department of Chemistry , University of Georgia , Athens , Georgia 30602 , United 
      States.
FAU - Kumar, Anil
AU  - Kumar A
AD  - Department of Chemistry , University of Georgia , Athens , Georgia 30602 , United 
      States.
FAU - Rong, Xiaoli
AU  - Rong X
FAU - Yang, Wei
AU  - Yang W
AD  - Department of Chemistry , University of Georgia , Athens , Georgia 30602 , United 
      States.
FAU - Chen, Hongmin
AU  - Chen H
AUID- ORCID: 0000-0002-6699-2300
AD  - State Key Laboratory of Molecular Vaccinology and Center for Molecular Imaging 
      and Translational Medicine, School of Public Health , Xiamen University , Fujian 
      361102 , China.
FAU - Xie, Jin
AU  - Xie J
AUID- ORCID: 0000-0002-8915-6233
AD  - Department of Chemistry , University of Georgia , Athens , Georgia 30602 , United 
      States.
FAU - Wang, Yimin
AU  - Wang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191219
PL  - United States
TA  - Bioconjug Chem
JT  - Bioconjugate chemistry
JID - 9010319
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Manganese Compounds)
RN  - 0 (Oxides)
RN  - 0 (Radiation-Sensitizing Agents)
RN  - F30N4O6XVV (Acridine Orange)
RN  - TF219GU161 (manganese dioxide)
SB  - IM
MH  - Acridine Orange/*therapeutic use
MH  - Animals
MH  - Cell Line, Tumor
MH  - Female
MH  - Fluorescent Dyes/*therapeutic use
MH  - Humans
MH  - Manganese Compounds/*therapeutic use
MH  - Mice, Nude
MH  - Nanoparticles/*therapeutic use/ultrastructure
MH  - Neoplasms/pathology/*radiotherapy
MH  - Oxides/*therapeutic use
MH  - Radiation-Sensitizing Agents/*therapeutic use
EDAT- 2019/12/07 06:00
MHDA- 2021/02/05 06:00
CRDT- 2019/12/07 06:00
PHST- 2019/12/07 06:00 [pubmed]
PHST- 2021/02/05 06:00 [medline]
PHST- 2019/12/07 06:00 [entrez]
AID - 10.1021/acs.bioconjchem.9b00751 [doi]
PST - ppublish
SO  - Bioconjug Chem. 2020 Jan 15;31(1):82-92. doi: 10.1021/acs.bioconjchem.9b00751. 
      Epub 2019 Dec 19.