PMID- 31809264
OWN - NLM
STAT- MEDLINE
DCOM- 20201118
LR  - 20201118
IS  - 2191-0251 (Electronic)
IS  - 0334-018X (Linking)
VI  - 33
IP  - 2
DP  - 2020 Feb 25
TI  - Evidence in obese children: contribution of tri-ponderal mass index or body mass 
      index to dyslipidemia, obesity-inflammation, and insulin sensitivity.
PG  - 223-231
LID - 10.1515/jpem-2019-0106 [doi]
AB  - Background Chronic inflammation plays a critical role in the development of 
      obesity-related metabolic dysfunction. The tri-ponderal mass index (TMI) may be 
      more effective than body mass index (BMI) for estimating body fat levels. This 
      study compared the efficacy of BMI and TMI in screening for dyslipidemia, insulin 
      sensitivity, and inflammation in childhood obesity. Methods This study included 
      80 children who were classified as normal weight, overweight or obese using 
      standardized BMI (BMI standard deviation score [SDS]) and TMI measurements. 
      Fasting blood glucose, insulin, homeostasis model assessment of insulin 
      resistance (HOMA-IR), high-density lipoprotein cholesterol (HDL-C) and 
      low-density lipoprotein cholesterol (LDL-C), triglycerides, total cholesterol, 
      liver function enzymes, leptin, serum free fatty acid (FFA), fetuin-A, monocyte 
      chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), and 
      interleukin (IL)-6 levels were evaluated using both classification systems. 
      Results LDL-C levels significantly differed within the groups by BMI, and serum 
      FFA levels differed only according to the TMI. Serum MCP-1, TNF-alpha, IL-6, and 
      fetuin-A levels showed no difference according to the TMI or BMI SDS. Fetuin-A 
      levels did not differ between the insulin-resistant and non-resistant cases. 
      Fetuin-A was the only inflammatory marker positively correlated with BMI. No 
      inflammatory markers correlated with TMI. Fetuin-A, MCP-1, TNF-alpha, and IL-6 
      correlated with each other, but not with metabolic parameters. Conclusions BMI 
      SDS and TMI were associated with metabolic disturbances in childhood obesity. 
      Weight versus heightn values may be related more to metabolic parameters than to 
      inflammatory changes.
FAU - Akcan, Nese
AU  - Akcan N
AUID- ORCID: 0000-0003-2583-5736
AD  - Department of Pediatric Endocrinology, Faculty of Medicine, Near East University, 
      99138 Nicosia, Turkish Republic of Northern Cyprus, Phone: +9 0392 675 10 00 
      (1388), Fax: +90 (392) 2236464.
FAU - Obaid, Moaaz
AU  - Obaid M
AD  - Department of Pediatric Endocrinology, Faculty of Medicine, Near East University, 
      Nicosia, Turkish Republic of Northern Cyprus.
FAU - Salem, Jana
AU  - Salem J
AD  - Department of Pediatric Endocrinology, Faculty of Medicine, Near East University, 
      Nicosia, Turkish Republic of Northern Cyprus.
FAU - Bundak, Ruveyde
AU  - Bundak R
AD  - Department of Pediatric Endocrinology, Faculty of Medicine, University of 
      Kyrenia, Kyrenia, Turkish Republic of Northern Cyprus.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/*blood
MH  - *Body Mass Index
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Dyslipidemias/blood/diagnosis/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Inflammation/blood/diagnosis/*epidemiology
MH  - *Insulin Resistance
MH  - Male
MH  - Overweight/*physiopathology
MH  - Pediatric Obesity/*physiopathology
MH  - Prognosis
MH  - Turkey/epidemiology
OTO - NOTNLM
OT  - FFAs
OT  - IL-6
OT  - MCP-1
OT  - TNF-alpha
OT  - body mass index
OT  - fetuin-A
OT  - tri-ponderal mass index
EDAT- 2019/12/07 06:00
MHDA- 2020/11/20 06:00
CRDT- 2019/12/07 06:00
PHST- 2019/02/26 00:00 [received]
PHST- 2019/10/17 00:00 [accepted]
PHST- 2019/12/07 06:00 [pubmed]
PHST- 2020/11/20 06:00 [medline]
PHST- 2019/12/07 06:00 [entrez]
AID - /j/jpem.ahead-of-print/jpem-2019-0106/jpem-2019-0106.xml [pii]
AID - 10.1515/jpem-2019-0106 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2020 Feb 25;33(2):223-231. doi: 
      10.1515/jpem-2019-0106.