PMID- 31809272
OWN - NLM
STAT- MEDLINE
DCOM- 20201123
LR  - 20210202
IS  - 1533-0311 (Electronic)
IS  - 0193-1091 (Linking)
VI  - 42
IP  - 3
DP  - 2020 Mar
TI  - Expression of Connexin 43 in 32 Cases of Merkel Cell Carcinoma.
PG  - 178-185
LID - 10.1097/DAD.0000000000001591 [doi]
AB  - INTRODUCTION: Connexins (Cxs) are channel proteins that allow direct connection 
      among cells and between cells and the extracellular space. There is very little 
      information in the literature on the expression of Cxs by Merkel cell carcinoma 
      (MCC). MATERIALS AND METHODS: Thirty-two cases of MCC were recovered from our 
      archives and studied immunohistochemically for Cx43. RESULTS: All our cases 
      expressed several neuroendocrine markers. Most cases showed 
      nonimmunohistochemically perceptible staining for Cx43. There was no difference 
      between Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative cases. One 
      case could not be evaluated. Only 2 cases showed a focal (10% of the tumor) 
      membranous staining of Cx43. One of these cases was MCPyV-negative and, in the 
      other, CM2B4 could not be evaluated. CM2B4 was positive in 18 cases and negative 
      in 13 cases, and it could not be evaluated in 1 case. CONCLUSIONS: MCC shows a 
      low Cx43 level, with no differences between MCPyV-positive and MCPyV-negative 
      cases. Therefore, this opens the door for Cx43 targeting in therapeutic 
      approaches to MCC.
FAU - Fernandez-Flores, Angel
AU  - Fernandez-Flores A
AD  - Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.
AD  - Department of Cellular Pathology, Hospital de la Reina, Ponferrada, Spain.
AD  - Department of Research, Institute for Biomedical Research of A Coruna (INIBIC), 
      University of A Coruna (UDC), A Coruna, Spain.
FAU - Varela-Vazquez, Adrian
AU  - Varela-Vazquez A
AD  - Department of Research, Institute for Biomedical Research of A Coruna (INIBIC), 
      University of A Coruna (UDC), A Coruna, Spain.
FAU - Suarez Penaranda, Jose Manuel
AU  - Suarez Penaranda JM
AD  - Department of Pathology, Clinical Hospital, Santiago de Compostela, Spain.
AD  - Department of Pathology and Forensic Sciences, Univeristy of Santiago de 
      Compostela, Santiago, Spain; and.
FAU - Mayan, Maria D
AU  - Mayan MD
AD  - Department of Research, Institute for Biomedical Research of A Coruna (INIBIC), 
      University of A Coruna (UDC), A Coruna, Spain.
FAU - Fonseca, Eduardo
AU  - Fonseca E
AD  - Department of Research, Institute for Biomedical Research of A Coruna (INIBIC), 
      University of A Coruna (UDC), A Coruna, Spain.
AD  - Department of Dermatology, Universitary Hospital of A Coruna, A Coruna, Spain.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Dermatopathol
JT  - The American Journal of dermatopathology
JID - 7911005
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Connexin 43)
RN  - 0 (GJA1 protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Merkel Cell/*metabolism/*pathology
MH  - Connexin 43/*biosynthesis
MH  - Female
MH  - Humans
MH  - Male
MH  - Skin Neoplasms/*metabolism/*pathology
EDAT- 2019/12/07 06:00
MHDA- 2020/11/24 06:00
CRDT- 2019/12/07 06:00
PHST- 2019/12/07 06:00 [pubmed]
PHST- 2020/11/24 06:00 [medline]
PHST- 2019/12/07 06:00 [entrez]
AID - 00000372-202003000-00004 [pii]
AID - 10.1097/DAD.0000000000001591 [doi]
PST - ppublish
SO  - Am J Dermatopathol. 2020 Mar;42(3):178-185. doi: 10.1097/DAD.0000000000001591.