PMID- 31810352
OWN - NLM
STAT- MEDLINE
DCOM- 20200417
LR  - 20200417
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 23
DP  - 2019 Dec 2
TI  - Thermoresponsive Catechol Based-Polyelectrolyte Complex Coatings for Controlled 
      Release of Bortezomib.
LID - 10.3390/ijms20236081 [doi]
LID - 6081
AB  - To overcome the high relapse rate of multiple myeloma (MM), a drug delivery 
      coating for functionalization of bone substitution materials (BSM) is reported 
      based on adhesive, catechol-containing and stimuli-responsive polyelectrolyte 
      complexes (PECs). This system is designed to deliver the MM drug bortezomib (BZM) 
      directly to the anatomical site of action. To establish a gradual BZM release, 
      the naturally occurring caffeic acid (CA) is coupled oxidatively to form 
      poly(caffeic acid) (PCA), which is used as a polyanion for complexation. The 
      catechol functionalities within the PCA are particularly suitable to form esters 
      with the boronic acid group of the BZM, which are then cleaved in the body fluid 
      to administer the drug. To achieve a more thorough control of the release, the 
      thermoresponsive poly(N-isoproplyacrylamide-co-dimethylaminoethylmethacrylate) 
      (P(NIPAM-co-DMAEMA)) was used as a polycation. Using turbidity measurements, it 
      was proven that the lower critical solution temperature (LCST) character of this 
      polymer was transferred to the PECs. Further special temperature dependent 
      attenuated total reflection infrared spectroscopy (ATR-FTIR) showed that coatings 
      formed by PEC immobilization exhibit a similar thermoresponsive performance. By 
      loading the coatings with BZM and studying the release in a model system, via 
      UV/Vis it was observed, that both aims, the retardation and the stimuli control 
      of the release, were achieved.
FAU - Reis, Berthold
AU  - Reis B
AD  - Leibniz-Institut fur Polymerforschung Dresden e.V., Department Polyelectrolytes 
      and Dispersions, Hohe Strasse 6, 01069 Dresden, Germany.
AD  - Technische Universitat Dresden, Department of Chemistry and Food Chemistry, 01062 
      Dresden, Germany.
FAU - Vehlow, David
AU  - Vehlow D
AD  - Leibniz-Institut fur Polymerforschung Dresden e.V., Department Polyelectrolytes 
      and Dispersions, Hohe Strasse 6, 01069 Dresden, Germany.
AD  - Technische Universitat Dresden, Department of Chemistry and Food Chemistry, 01062 
      Dresden, Germany.
FAU - Rust, Tarik
AU  - Rust T
AD  - Universitat Paderborn, Department of Chemistry, Warburger Str. 100, 33106 
      Paderborn, Germany.
FAU - Kuckling, Dirk
AU  - Kuckling D
AUID- ORCID: 0000-0001-6003-151X
AD  - Universitat Paderborn, Department of Chemistry, Warburger Str. 100, 33106 
      Paderborn, Germany.
FAU - Muller, Martin
AU  - Muller M
AUID- ORCID: 0000-0001-8961-4604
AD  - Leibniz-Institut fur Polymerforschung Dresden e.V., Department Polyelectrolytes 
      and Dispersions, Hohe Strasse 6, 01069 Dresden, Germany.
AD  - Technische Universitat Dresden, Department of Chemistry and Food Chemistry, 01062 
      Dresden, Germany.
LA  - eng
GR  - Project number 107540325 - TRR 79, project M7/Deutsche Forschungsgemeinschaft/
PT  - Journal Article
DEP - 20191202
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Caffeic Acids)
RN  - 0 (Catechols)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Methacrylates)
RN  - 0 (Polyelectrolytes)
RN  - 0 (Polymers)
RN  - 69G8BD63PP (Bortezomib)
RN  - LF3AJ089DQ (catechol)
RN  - O0V97PV2G1 (2-(dimethylamino)ethyl methacrylate)
RN  - U2S3A33KVM (caffeic acid)
SB  - IM
MH  - Bortezomib/chemistry/*pharmacology
MH  - Caffeic Acids/chemical synthesis/*chemistry
MH  - Catechols/chemistry/pharmacology
MH  - Coated Materials, Biocompatible/chemical synthesis/chemistry
MH  - Delayed-Action Preparations/chemistry/pharmacology
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Methacrylates/chemical synthesis/chemistry/pharmacology
MH  - Multiple Myeloma/*drug therapy/pathology
MH  - Polyelectrolytes/chemical synthesis/chemistry/pharmacology
MH  - Polymers/chemical synthesis/chemistry/pharmacology
PMC - PMC6928965
OTO - NOTNLM
OT  - bortezomib
OT  - catechol chemistry
OT  - controlled release
OT  - multiple myeloma
OT  - poly(caffeic acid)
OT  - polyelectrolyte complex coatings
OT  - thermoresponsive coatings
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2019/12/08 06:00
MHDA- 2020/04/18 06:00
PMCR- 2019/12/01
CRDT- 2019/12/08 06:00
PHST- 2019/10/29 00:00 [received]
PHST- 2019/11/27 00:00 [revised]
PHST- 2019/11/29 00:00 [accepted]
PHST- 2019/12/08 06:00 [entrez]
PHST- 2019/12/08 06:00 [pubmed]
PHST- 2020/04/18 06:00 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - ijms20236081 [pii]
AID - ijms-20-06081 [pii]
AID - 10.3390/ijms20236081 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Dec 2;20(23):6081. doi: 10.3390/ijms20236081.