PMID- 31810551
OWN - NLM
STAT- MEDLINE
DCOM- 20200415
LR  - 20230721
IS  - 1937-6448 (Print)
IS  - 1937-6448 (Linking)
VI  - 348
DP  - 2019
TI  - Dendritic cell subsets and locations.
PG  - 1-68
LID - S1937-6448(19)30067-X [pii]
LID - 10.1016/bs.ircmb.2019.07.004 [doi]
AB  - Dendritic cells (DCs) are a unique class of immune cells that act as a bridge 
      between innate and adaptive immunity. The discovery of DCs by Cohen and Steinman 
      in 1973 laid the foundation for DC biology, and the advances in the field 
      identified different versions of DCs with unique properties and functions. DCs 
      originate from hematopoietic stem cells, and their differentiation is modulated 
      by Flt3L. They are professional antigen-presenting cells that patrol the 
      environmental interphase, sites of infection, or infiltrate pathological tissues 
      looking for antigens that can be used to activate effector cells. DCs are 
      critical for the initiation of the cellular and humoral immune response and 
      protection from infectious diseases or tumors. DCs can take up antigens using 
      specialized surface receptors such as endocytosis receptors, phagocytosis 
      receptors, and C type lectin receptors. Moreover, DCs are equipped with an array 
      of extracellular and intracellular pattern recognition receptors for sensing 
      different danger signals. Upon sensing the danger signals, DCs get activated, 
      upregulate costimulatory molecules, produce various cytokines and chemokines, 
      take up antigen and process it and migrate to lymph nodes where they present 
      antigens to both CD8 and CD4 T cells. DCs are classified into different subsets 
      based on an integrated approach considering their surface phenotype, expression 
      of unique and conserved molecules, ontogeny, and functions. They can be broadly 
      classified as conventional DCs consisting of two subsets (DC1 and DC2), 
      plasmacytoid DCs, inflammatory DCs, and Langerhans cells.
CI  - (c) 2019 Elsevier Inc. All rights reserved.
FAU - Balan, Sreekumar
AU  - Balan S
AD  - The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, 
      NY, United States. Electronic address: sreekumar.balan@mssm.edu.
FAU - Saxena, Mansi
AU  - Saxena M
AD  - The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, 
      NY, United States.
FAU - Bhardwaj, Nina
AU  - Bhardwaj N
AD  - The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, 
      NY, United States; Parker Institute for Cancer Immunotherapy, San Francisco, CA, 
      United States.
LA  - eng
GR  - R01 AI081848/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20190903
PL  - Netherlands
TA  - Int Rev Cell Mol Biol
JT  - International review of cell and molecular biology
JID - 101475846
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*classification/*cytology/immunology
MH  - Humans
OTO - NOTNLM
OT  - BDCA1
OT  - BDCA2
OT  - BDCA3
OT  - CDc2
OT  - DC subsets
OT  - Dendritic cell
OT  - LCs
OT  - SIRPa
OT  - XCR1
OT  - cDC1
OT  - infDC
OT  - pDC
EDAT- 2019/12/08 06:00
MHDA- 2020/04/16 06:00
CRDT- 2019/12/08 06:00
PHST- 2019/12/08 06:00 [entrez]
PHST- 2019/12/08 06:00 [pubmed]
PHST- 2020/04/16 06:00 [medline]
AID - S1937-6448(19)30067-X [pii]
AID - 10.1016/bs.ircmb.2019.07.004 [doi]
PST - ppublish
SO  - Int Rev Cell Mol Biol. 2019;348:1-68. doi: 10.1016/bs.ircmb.2019.07.004. Epub 
      2019 Sep 3.